{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T11:12:16Z","timestamp":1775387536797,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015158","name":"Fondren Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015158","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2023,1]]},"abstract":"ABSTRACT<\/jats:title>Objective<\/jats:title>To determine if preoperative cervical length in the low\u2013normal range increases the risk of adverse perinatal outcome in patients undergoing fetoscopic spina bifida repair.<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a retrospective cohort study of patients who underwent fetal spina bifida repair between September 2014 and May 2022 at a single center. Cervical length was measured on transvaginal ultrasound during the week before surgery. Eligibility for laparotomy\u2010assisted fetoscopic spina bifida repair was as per the criteria of the Management of Myelomeningocele Study, although maternal body mass index (BMI) up to 40\u2009kg\/m2<\/jats:sup> was allowed. Laparotomy\u2010assisted fetoscopic spina bifida repair was performed, with carbon dioxide insufflation via two 12\u2010French ports in the exteriorized uterus. All patients received the same peri\u2010 and postoperative tocolysis regimen, including magnesium sulfate, nifedipine and indomethacin. Postoperative follow\u2010up ultrasound scans were performed either weekly (<\u200932\u2009weeks' gestation) or twice a week (\u2265\u200932\u2009weeks). Perinatal outcome was compared between patients with a preoperative cervical length of 25\u201330\u2009mm vs<\/jats:italic> those with a cervical length >\u200930\u2009mm. Logistic regression analyses and generalized linear mixed regression analyses were used to predict delivery at less than 30, 34 and 37\u2009weeks' gestation.<\/jats:p><\/jats:sec>Results<\/jats:title>The study included 99 patients with a preoperative cervical length >\u200930\u2009mm and 12 patients with a cervix 25\u201330\u2009mm in length. One further case which underwent spina bifida repair was excluded because cervical length was measured >\u20091\u2009week before surgery. No differences in maternal demographics, gestational age (GA) at surgery, duration of surgery or duration of carbon dioxide uterine insufflation were observed between groups. Cases with low\u2013normal cervical length had an earlier GA at delivery (median (range), 35.2 (25.1\u201339.7) weeks vs<\/jats:italic> 38.2 (26.0\u201340.9) weeks; P<\/jats:italic>\u2009=\u20090.01), higher rates of delivery at <\u200934\u2009weeks (41.7% vs<\/jats:italic> 10.2%; P<\/jats:italic>\u2009=\u20090.01) and <\u200930\u2009weeks (25.0% vs<\/jats:italic> 1.0%; P<\/jats:italic>\u2009<\u20090.01) and a higher rate of preterm prelabor rupture of membranes (PPROM) (58.3% vs<\/jats:italic> 26.3%; P<\/jats:italic>\u2009=\u20090.04) at an earlier GA (mean\u2009\u00b1\u2009SD, 29.3\u2009\u00b1\u20094.0\u2009weeks vs<\/jats:italic> 33.0\u2009\u00b1\u20092.4\u2009weeks; P<\/jats:italic>\u2009=\u20090.05) compared to those with a normal cervical length. Neonates of cases with low\u2013normal cervical length had a longer stay in the neonatal intensive care unit (20 (7\u2013162) days vs<\/jats:italic> 9 (3\u2013253) days; P<\/jats:italic>\u2009=\u20090.02) and higher rates of respiratory distress syndrome (50.0% vs<\/jats:italic> 14.4%; P<\/jats:italic>\u2009<\u20090.01), sepsis (16.7% vs<\/jats:italic> 1.0%; P<\/jats:italic>\u2009=\u20090.03), necrotizing enterocolitis (16.7% vs<\/jats:italic> 0%; P<\/jats:italic>\u2009=\u20090.01) and retinopathy (33.3% vs<\/jats:italic> 1.0%; P<\/jats:italic>\u2009<\u20090.01). There was an association between preoperative cervical length and risk of delivery at <\u200930\u2009weeks which was significant only for patients with a maternal BMI <\u200925\u2009kg\/m2<\/jats:sup> (odds ratio, 0.37 (95%\u2009CI, 0.07\u20130.81); P<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Low\u2013normal cervical length (25\u201330\u2009mm) as measured before in\u2010utero<\/jats:italic> laparotomy\u2010assisted fetoscopic spina bifida repair may increase the risk of adverse perinatal outcomes, including PPROM and preterm birth, leading to higher rates of neonatal complications. These data warrant further research and are of critical relevance for clinical teams considering the eligibility of patients for in\u2010utero<\/jats:italic> spina bifida repair. Based on this evidence, patients with a low\u2013normal cervical length should be aware of their increased risk for adverse perinatal outcome. \u00a9 2022 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.26070","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T18:53:10Z","timestamp":1663095190000},"page":"74-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of preoperative low\u2013normal cervical length on perinatal outcome after laparotomy\u2010assisted fetoscopic spina bifida repair"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0265-9859","authenticated-orcid":false,"given":"M.","family":"Sanz Cortes","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Texas Children's Hospital & Baylor College of Medicine Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8583-2054","authenticated-orcid":false,"given":"R.","family":"Corroenne","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Texas Children's Hospital & Baylor College of Medicine Houston TX USA"},{"name":"Department of Obstetrics University Hospital of Angers Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Texas Children's Hospital & Baylor College of Medicine Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Sangi\u2010Haghpeykar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Texas Children's Hospital & Baylor College of Medicine Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Mandy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Texas Children's Hospital & Baylor College of Medicine Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"VanLoh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Texas Children's Hospital & Baylor College of Medicine Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-7965","authenticated-orcid":false,"given":"A.","family":"Nassr","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Texas Children's Hospital & Baylor College of Medicine Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9830-2212","authenticated-orcid":false,"given":"J.","family":"Espinoza","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Texas Children's Hospital & Baylor College of Medicine Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Donepudi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Texas Children's Hospital & Baylor College of Medicine Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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