{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:06:42Z","timestamp":1793329602441,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010686","name":"H2020 European Institute of Innovation and Technology","doi-asserted-by":"publisher","award":["211015"],"award-info":[{"award-number":["211015"]}],"id":[{"id":"10.13039\/100010686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To study the reproductive outcomes of women with a unicornuate uterus and compare them to those of women with no congenital uterine anomaly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a single\u2010center, retrospective cohort study. Cases were women aged at least 16\u2009years who were diagnosed with a unicornuate uterus on transvaginal\/transrectal ultrasound between January 2008 and September 2021. Controls were women with no congenital uterine anomaly matched 1:1 by age and body mass index. The primary outcome was live\u2010birth rate. Secondary outcomes were pregnancy loss (miscarriage, ectopic pregnancy, termination of pregnancy), preterm delivery, mode of delivery and concomitant gynecological abnormalities (endometriosis, adenomyosis, fibroids).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Included in the study were 326 cases and 326 controls. Women with a unicornuate uterus had a significantly lower live\u2010birth rate (184\/388 (47.4%)\n                      <jats:italic>vs<\/jats:italic>\n                      229\/396 (57.8%);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004) and higher rates of overall miscarriage (178\/424 (42.0%)\n                      <jats:italic>vs<\/jats:italic>\n                      155\/465 (33.3%); adjusted odds ratio (aOR), 2.21 (95%\u2009CI, 1.42\u20133.42),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), ectopic pregnancy (26\/424 (6.1%)\n                      <jats:italic>vs<\/jats:italic>\n                      11\/465 (2.4%); aOR, 2.52 (95%\u2009CI, 1.22\u20135.22),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01), preterm delivery (45\/184 (24.5%)\n                      <jats:italic>vs<\/jats:italic>\n                      17\/229 (7.4%); aOR, 3.04 (95%\u2009CI, 1.52\u20135.97),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001) and Cesarean delivery (116\/184 (63.0%)\n                      <jats:italic>vs<\/jats:italic>\n                      70\/229 (30.6%); aOR, 2.54 (95%\u2009CI, 1.67\u20133.88),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Rudimentary\u2010horn pregnancies accounted for 7\/26 (26.9%) ectopic pregnancies in the study group. Women with a unicornuate uterus were more likely to have endometriosis (17.5%\n                      <jats:italic>vs<\/jats:italic>\n                      10.7%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.018) and adenomyosis (26.7%\n                      <jats:italic>vs<\/jats:italic>\n                      15.6%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001), but were not more likely to have fibroids compared with controls. Women with a functional rudimentary horn were more likely to have pelvic endometriosis compared to those without (odds ratio, 2.4 (95%\u2009CI, 1.4\u20134.1),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Pregnant women with a unicornuate uterus should be classified as high risk. Removal of a functional rudimentary horn should be discussed with the patient to prevent a rudimentary\u2010horn ectopic pregnancy. \u00a9 2022 The Authors.\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.26073","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T15:28:55Z","timestamp":1663082935000},"page":"99-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Reproductive outcome in 326 women with unicornuate uterus"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2635-4504","authenticated-orcid":false,"given":"T.","family":"Tellum","sequence":"first","affiliation":[{"name":"Institute for Women's Health, Faculty of Population Health Sciences University College London London UK"},{"name":"Department of Gynecology Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Bracco","sequence":"additional","affiliation":[{"name":"Institute for Women's Health, Faculty of Population Health Sciences University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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