{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:24:52Z","timestamp":1788866692892,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI13\/02405"],"award-info":[{"award-number":["PI13\/02405"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the ability to predict perinatal survival and severe neonatal morbidity of cases with early\u2010onset fetal growth restriction (eoFGR) using maternal variables, ultrasound parameters and angiogenic markers at the time of diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective observational study in a cohort of singleton pregnancies with a diagnosis of eoFGR (&lt;\u200932\u2009weeks of gestation). At diagnosis of eoFGR, complete assessment was performed, including ultrasound examination (anatomy, biometry and Doppler assessment) and maternal serum measurement of the angiogenic biomarkers, soluble fms\u2010like tyrosine kinase\u20101 (sFlt\u20101) and placental growth factor (PlGF). Logistic regression models for the prediction of perinatal survival (in cases diagnosed at &lt;\u200928\u2009weeks) and severe neonatal morbidity (in all liveborn cases) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 210 eoFGR cases were included, of which 185 (88.1%) survived perinatally. The median gestational age at diagnosis was 27\u2009+\u20090\u2009weeks. All cases diagnosed at \u2265\u200928\u2009weeks survived. In cases diagnosed &lt;\u200928\u2009weeks, survivors (<jats:italic>vs<\/jats:italic> non\u2010survivors) had a higher gestational age (26.1 <jats:italic>vs<\/jats:italic> 24.4\u2009weeks), estimated fetal weight (EFW; 626 <jats:italic>vs<\/jats:italic> 384\u2009g), cerebroplacental ratio (1.1 <jats:italic>vs<\/jats:italic> 0.9), PlGF (41 <jats:italic>vs<\/jats:italic> 18\u2009pg\/mL) and PlGF multiples of the median (MoM; 0.10 <jats:italic>vs<\/jats:italic> 0.06) and lower sFlt\u20101\/PlGF ratio (129 <jats:italic>vs<\/jats:italic> 479) at the time of diagnosis (all <jats:italic>P\u2009&lt;<\/jats:italic>\u20090.001). The best combination of two variables for predicting perinatal survival was provided by EFW and PlGF MoM (area under the receiver\u2010operating\u2010characteristics curve (AUC), 0.84 (95%\u2009CI, 0.75\u20130.92)). These were also the best variables for predicting severe neonatal morbidity (AUC, 0.73 (95%\u2009CI, 0.66\u20130.80)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A model combining EFW and maternal serum PlGF predicts accurately perinatal survival in eoFGR cases diagnosed before 28\u2009weeks of gestation. Prenatal prediction of severe neonatal morbidity in eoFGR cases is modest regardless of the model used. \u00a9 2022 The Authors. <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.26116","type":"journal-article","created":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T19:31:52Z","timestamp":1668281512000},"page":"181-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Prediction of perinatal survival in early\u2010onset fetal growth restriction: role of placental growth factor"],"prefix":"10.1002","volume":"61","author":[{"given":"J.","family":"Rodr\u00edguez\u2010Calvo","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynaecology Hospital Universitario 12 de Octubre, Instituto de Investigaci\u00f3n Hospital 12 de Octubre (imas12)  Madrid Spain"},{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS network) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9456-4100","authenticated-orcid":false,"given":"C.","family":"Villala\u00edn","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynaecology Hospital Universitario 12 de Octubre, Instituto de Investigaci\u00f3n Hospital 12 de Octubre (imas12)  Madrid Spain"},{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS network) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. I.","family":"G\u00f3mez\u2010Arriaga","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynaecology Hospital Universitario 12 de Octubre, Instituto de Investigaci\u00f3n Hospital 12 de Octubre (imas12)  Madrid Spain"},{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS network) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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