{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:09:35Z","timestamp":1786705775521,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the role of antenatal administration of corticosteroids for fetal lung maturation on the short\u2010term perinatal outcome of pregnancy complicated by late fetal growth restriction (FGR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cohort study was a secondary analysis of a multicenter prospective observational study, the TRUFFLE\u20102 feasibility study, conducted between 2017 and 2018 in 33 European perinatal centers. The study included women with a singleton pregnancy from 32\u2009+\u20090 to 36\u2009+\u20096\u2009weeks of gestation with a fetus considered at risk for FGR, defined as estimated fetal weight (EFW) and\/or fetal abdominal circumference &lt;\u200910<jats:sup>th<\/jats:sup> percentile, or umbilicocerebral ratio (UCR) \u2265\u200995<jats:sup>th<\/jats:sup> percentile or a drop  of more than 40 percentile points in abdominal circumference measurement from the 20\u2010week scan. For the purposes of the current study, we identified women who received a single course of steroids to improve fetal lung maturation before delivery. Each exposed pregnancy was matched with one that did not receive antenatal corticosteroids (ACS) (control), based on gestational age at delivery and birth weight. The primary adverse outcome was a composite of abnormal condition at birth, major neonatal morbidity or perinatal death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 86 pregnancies that received ACS were matched to 86 controls. The two groups were similar with respect to gestational age (33.1 <jats:italic>vs<\/jats:italic> 33.3\u2009weeks), EFW (1673 <jats:italic>vs<\/jats:italic> 1634\u2009g) and UCR (0.68 <jats:italic>vs<\/jats:italic> 0.62) at inclusion, and gestational age at delivery (35.5 <jats:italic>vs<\/jats:italic> 35.9\u2009weeks) and birth weight (1925 <jats:italic>vs<\/jats:italic> 1948\u2009g). No significant differences were observed between the exposed and non\u2010exposed groups in the incidence of composite adverse outcome (28% <jats:italic>vs<\/jats:italic> 24%; <jats:italic>P<\/jats:italic>\u2009=\u20090.73) or  any of its elements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present data do not show a beneficial effect of steroids on short\u2010term outcome of fetuses with late FGR. \u00a9 2023 The Authors. <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.26127","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T13:05:21Z","timestamp":1669122321000},"page":"191-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Antenatal corticosteroids and perinatal outcome in late fetal growth restriction: analysis of prospective cohort"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6353-9383","authenticated-orcid":false,"given":"A.","family":"Familiari","sequence":"first","affiliation":[{"name":"Department of Woman and Child Health and Public Health Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8512-2597","authenticated-orcid":false,"given":"R.","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Elizabeth Garrett Anderson Institute for Women's Health University College London  London UK"},{"name":"Fetal Medicine Unit University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6708-6396","authenticated-orcid":false,"given":"G. H. A.","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Obstetrics University Medical Center  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2104-5561","authenticated-orcid":false,"given":"C.","family":"Lees","sequence":"additional","affiliation":[{"name":"Centre for Fetal Care, Department of Obstetrics and Gynaecology Queen Charlotte's and Chelsea Hospital, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3924-2149","authenticated-orcid":false,"given":"H.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam University Medical Center (Location AMC), University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7793-714X","authenticated-orcid":false,"given":"F.","family":"Prefumo","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Unit IRCCS Istituto Giannina Gaslini  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the TRUFFLE\u20102 feasibility study investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"CD004454","article-title":"Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth","volume":"12","author":"Mcgoldrick E","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00169-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.11.3.199.203"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0096(200103\/04)29:3<146::AID-JCU1014>3.0.CO;2-I"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050701463662"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(81)90273-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000263348"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.10.4979"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)91412-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.95.4.534"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904223401603"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70513-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-199902000-00003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340903176784"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(99)00265-3"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-1058"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22125"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.181.1.1887021"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2020.100153"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-055543"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.50.4.515"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(95)02052-7"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200106000-00016"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2016.03.016"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2014.57.3.101"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200111000-00008"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1516783"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.07.023"}],"container-title":["Ultrasound in Obstetrics &amp; 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