{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:03:54Z","timestamp":1775001834346,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate measurements on neurosonography of midbrain morphology, including corpus callosum\u2013fastigium length and tectal length, in late\u2010onset small fetuses subclassified as small\u2010for\u2010gestational\u2010age (SGA) or growth\u2010restricted (FGR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a case\u2013control study of consecutive singleton pregnancies delivered at term at a single center between January 2019 and July 2021, including those with late\u2010onset smallness (estimated fetal weight (EFW) &lt;\u200910<jats:sup>th<\/jats:sup> centile) and appropriate\u2010for\u2010gestational\u2010age controls matched by age at neurosonography. Small fetuses were further subdivided into SGA (EFW between 3<jats:sup>rd<\/jats:sup> and 9<jats:sup>th<\/jats:sup> centile and normal fetoplacental Doppler) and FGR (EFW &lt;\u20093<jats:sup>rd<\/jats:sup> centile or EFW &lt;\u200910<jats:sup>th<\/jats:sup> centile with abnormal cerebroplacental ratio and\/or uterine artery Doppler). Transvaginal neurosonography was performed at a mean\u2009\u00b1\u2009SD gestational age of 33\u2009\u00b1\u20091\u2009weeks in all fetuses to evaluate corpus callosum\u2013fastigium length and tectal length in the midsagittal plane. Intra\u2010 and interobserver agreement was evaluated using the intraclass correlation coefficient and Bland\u2013Altman plots.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 70 fetuses with late\u2010onset smallness (29 with SGA and 41 with FGR) and 70 controls were included. Compared with controls, small fetuses showed significantly shorter corpus callosum\u2013fastigium length (median (interquartile range), 44.7 (43.3\u201346.8) mm <jats:italic>vs<\/jats:italic> 43.7 (42.4\u201345.5) mm, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and tectal length (mean\u2009\u00b1\u2009SD, 10.5\u2009\u00b1\u20090.9 <jats:italic>vs<\/jats:italic> 9.6\u2009\u00b1\u20091.0\u2009mm, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). These changes were more prominent in FGR fetuses, with a linear trend across groups according to severity of smallness. Corpus callosum\u2013fastigium length and tectal length measurements showed excellent intra\u2010 and interobserver reliability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Small fetuses exhibited shorter corpus callosum\u2013fastigium length and tectal length compared with controls, and these differences were more pronounced in fetuses with more severe smallness. These findings illustrate the potential value of midbrain measurements assessed on neurosonography as biomarkers for brain development in a high\u2010risk population. However, further studies correlating these parameters with postnatal functional tests and follow\u2010up are needed. \u00a9 2023 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.26169","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T08:03:23Z","timestamp":1675238603000},"page":"226-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Corpus callosum\u2013fastigium and tectal lengths in late\u2010onset small fetuses"],"prefix":"10.1002","volume":"62","author":[{"given":"D. L.","family":"Lip\u2010Sosa","sequence":"first","affiliation":[{"name":"BCNatal\u2013Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u Universitat de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"P\u00e9rez\u2010Cruz","sequence":"additional","affiliation":[{"name":"BCNatal\u2013Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u Universitat de Barcelona  Barcelona Spain"},{"name":"Institut de Recerca Sant Joan de D\u00e9u  Barcelona Spain"},{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Ahumada\u2010Droguett","sequence":"additional","affiliation":[{"name":"BCNatal\u2013Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u Universitat de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Ribas\u2010Prats","sequence":"additional","affiliation":[{"name":"Institut de Recerca Sant Joan de D\u00e9u  Barcelona Spain"},{"name":"Brainlab\u2013Cognitive Neuroscience Research Group, Department of Clinical Psychology and Psychobiology University of Barcelona  Barcelona Spain"},{"name":"Institute of Neurosciences University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Puertollano","sequence":"additional","affiliation":[{"name":"Institut de Recerca Sant Joan de D\u00e9u  Barcelona Spain"},{"name":"Brainlab\u2013Cognitive Neuroscience Research Group, Department of Clinical Psychology and Psychobiology University of Barcelona  Barcelona Spain"},{"name":"Institute of Neurosciences University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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