{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:52:42Z","timestamp":1770742362542,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Pre\u2010eclampsia has been associated with cardiovascular, cerebrovascular and\/or psychological complaints. Signs of altered brain morphology and more white\u2010matter hyperintensities (WMHs) during and shortly after pre\u2010eclampsia have been observed in some, but not all, studies. We compared volumes of cerebral structures and the number of WMHs between formerly pre\u2010eclamptic women and those with normotensive gestational history and assessed the effect of age on brain volumes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Structural 7\u2010Tesla magnetic resonance imaging of the brain was performed in 59 formerly pre\u2010eclamptic women (aged 37\u2009\u00b1\u20096\u2009years, 0.5\u201316\u2009years postpartum) and 20 women with a history of normotensive pregnancy (aged 39\u2009\u00b1\u20095\u2009years, 1\u201318\u2009years postpartum). Fazekas scores were obtained to assess WMH load. Volumes of the whole brain, gray and white matter, brain lobes, and ventricular and pericortical cerebrospinal fluid (CSF) spaces were calculated after semiautomatic segmentation. Group differences were analyzed using ANCOVA and Bayes factors. Results were adjusted for age, educational attainment, presence of current hypertension and total intracranial volume. The effect of age on cerebral volumes was analyzed using linear regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No changes in global and local brain volumes were observed between formerly pre\u2010eclamptic and control women. Also, no difference in WMH load was observed. Independent of pre\u2010eclamptic history, gray\u2010matter volume significantly decreased with age, while ventricular and pericortical CSF space volumes significantly increased with age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Volumetric changes of the cerebrum are age\u2010related but are independent of pre\u2010eclamptic history in the first two decades after childbirth. No evidence of greater WMH load after pre\u2010eclampsia was found. \u00a9 2023 The Authors. <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.26172","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T18:22:40Z","timestamp":1675362160000},"page":"115-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cerebral volume is unaffected after pre\u2010eclampsia"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4880-2670","authenticated-orcid":false,"given":"L. P. W.","family":"Canjels","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"School for Oncology and Developmental Biology (GROW) Maastricht University  Maastricht The Netherlands"},{"name":"Department of Obstetrics and Gynecology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4478-7207","authenticated-orcid":false,"given":"R. J.","family":"Alers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"School for Oncology and Developmental Biology (GROW) Maastricht University  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"van de Ven","sequence":"additional","affiliation":[{"name":"Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience Maastricht University  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. P. M.","family":"Hurks","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience Maastricht University  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. C.","family":"Gerretsen","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Brandt","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"School for Cardiovascular Diseases (CARIM) Maastricht University  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"Kooi","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"School for Cardiovascular Diseases (CARIM) Maastricht University  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F. A.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"School for Mental Health and Neuroscience (MHeNS) Maastricht University  Maastricht The Netherlands"},{"name":"Department of Electrical Engineering Eindhoven University of Technology  Eindhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. H.","family":"Backes","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"School for Cardiovascular Diseases (CARIM) Maastricht University  Maastricht The Netherlands"},{"name":"School for Mental Health and Neuroscience (MHeNS) Maastricht University  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ghossein\u2010Doha","sequence":"additional","affiliation":[{"name":"School for Oncology and Developmental Biology (GROW) Maastricht University  Maastricht The Netherlands"},{"name":"School for Cardiovascular Diseases (CARIM) Maastricht University  Maastricht The Netherlands"},{"name":"Department of Cardiology Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E. 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