{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:14:26Z","timestamp":1792800866439,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the predictive performance of the Fetal Medicine Foundation (FMF) first\u2010trimester screening algorithm for pre\u2010eclampsia in a Danish population and compare screening performance with that of the current Danish strategy, which is based on maternal risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective study of women with a singleton pregnancy attending for their first\u2010trimester ultrasound scan and screening for aneuploidies at six Danish university hospitals between May 2019 and December 2020. Prenatal data on maternal characteristics and medical history were recorded, and measurements of mean arterial pressure (MAP), uterine artery pulsatility index (UtA\u2010PI), serum pregnancy\u2010associated plasma protein\u2010A (PAPP\u2010A) and serum placental growth factor (PlGF) were collected without performing a risk assessment for pre\u2010eclampsia. Information on acetylsalicylic acid use was recorded. After delivery, pregnancy outcome, including gestational age at delivery and pre\u2010eclampsia diagnosis, was recorded. Pre\u2010eclampsia risk assessment for each woman was calculated blinded to outcome using the FMF screening algorithm following adjustment to the Danish population. Detection rates (DRs) of the FMF algorithm were calculated for a fixed screen\u2010positive rate (SPR) of 10% and for the SPR achieved in the current Danish screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 8783 pregnant women were included, with a median age of 30.8 (interquartile range (IQR), 28.1\u201333.9)\u2009years. The majority were white (95%), naturally conceiving (90%), non\u2010smokers (97%) and had no family history of pre\u2010eclampsia (96%). The median body mass index was 23.4 (IQR, 21.2\u201326.6) kg\/m<jats:sup>2<\/jats:sup>. A complete risk assessment including maternal characteristics, MAP, UtA\u2010PI, PlGF and PAPP\u2010A was available for 8156 women (92.9%). In these women, UtA\u2010PI was measured bilaterally with a median value of 1.58 (IQR, 1.27\u20131.94) and the median resting MAP of 80.5 (IQR, 76.1\u201385.4) mmHg in two consecutive measurements. Among these, 303 (3.7%) developed pre\u2010eclampsia, including 55 (0.7%) cases of pre\u2010eclampsia with delivery &lt;\u200937\u2009weeks of gestation and 16 (0.2%) cases of pre\u2010eclampsia with delivery &lt;\u200934\u2009weeks. At a SPR of 10%, combined screening using the FMF algorithm based on maternal characteristics, MAP, UtA\u2010PI, PlGF and PAPP\u2010A had a DR of 77.4% (95%\u2009CI, 57.6\u201397.2%) for pre\u2010eclampsia with delivery &lt;\u200934\u2009weeks, 66.8% (95%\u2009CI, 54.4\u201379.1%) for pre\u2010eclampsia with delivery &lt;\u200937\u2009weeks and 44.1% (95%\u2009CI, 38.5\u201349.7%) for pre\u2010eclampsia with delivery at any gestational age. The current Danish screening strategy using maternal risk factors detected 25.0% of women with pre\u2010eclampsia with delivery &lt;\u200934\u2009weeks and 19.6% of women with pre\u2010eclampsia with delivery &lt;\u200937\u2009weeks at a SPR of 3.4%. When applying the FMF algorithm including maternal characteristics, MAP, UtA\u2010PI and PlGF at the fixed SPR of 3.4%, the DRs were 60.5% (95%\u2009CI, 36.9\u201384.1%) for PE with delivery &lt;\u200934\u2009weeks and 45.2% (95%\u2009CI, 32.0\u201358.5%) for PE with delivery &lt;\u200937\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this large Danish multicenter study, the FMF algorithm based on maternal characteristics, MAP, UtA\u2010PI, PlGF and PAPP\u2010A predicted 77.4% of cases with pre\u2010eclampsia with delivery &lt;\u200934\u2009weeks and 66.8% of cases with pre\u2010eclampsia with delivery &lt;\u200937\u2009weeks of gestation at a SPR of 10%, suggesting that the performance of the algorithm in a Danish cohort matches that in other populations. \u00a9 2023 The Authors. Ultrasound in Obstetrics &amp; Gynecology published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.26183","type":"journal-article","created":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T20:49:36Z","timestamp":1677358176000},"page":"682-690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Pre\u2010eclampsia screening in Denmark (<scp>PRESIDE<\/scp>): national validation study"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9353-8958","authenticated-orcid":false,"given":"I.","family":"Riishede","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Obstetrics, Center of Fetal Medicine Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Rode","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Center of Fetal Medicine Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Biochemistry Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Sperling","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fetal Medicine Unit Odense University Hospital  Odense Denmark"},{"name":"Faculty of Health Sciences University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Overgaard","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences University of Southern Denmark  Odense Denmark"},{"name":"Department of Clinical Biochemistry Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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