{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:38:02Z","timestamp":1792881482698,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"publisher","award":["UK Charity number 1037116"],"award-info":[{"award-number":["UK Charity number 1037116"]}],"id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011272","name":"FP7 Health","doi-asserted-by":"publisher","award":["FP7\u2010HEALTH\u20102013\u2010INNOVATION\u20102; ASPRE Project number"],"award-info":[{"award-number":["FP7\u2010HEALTH\u20102013\u2010INNOVATION\u20102; ASPRE Project number"]}],"id":[{"id":"10.13039\/100011272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The mechanism by which aspirin prevents pre\u2010eclampsia is poorly understood, and its effects on biomarkers throughout pregnancy are unknown. We aimed to investigate the effects of aspirin on mean arterial pressure (MAP) and mean uterine artery pulsatility index (UtA\u2010PI) using repeated measures from women at increased risk of preterm pre\u2010eclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a longitudinal secondary analysis of the Combined Multimarker Screening and Randomized Patient Treatment with Aspirin for Evidence\u2010Based Pre\u2010eclampsia Prevention (ASPRE) trial using repeated measures of MAP and UtA\u2010PI. In the trial, 1620 women at increased risk of preterm pre\u2010eclampsia were identified using the Fetal Medicine Foundation algorithm at 11\u2009+\u20090 to 13\u2009+\u20096\u2009weeks, of whom 798 were randomly assigned to receive 150\u2009mg\/day aspirin and 822 were assigned to receive placebo daily from 11\u201314\u2009weeks to 36\u2009weeks of gestation or delivery, whichever came first. MAP and UtA\u2010PI were measured at baseline and follow\u2010up visits at 19\u201324, 32\u201334 and 36\u2009weeks of gestation. Generalized additive mixed models with treatment by gestational age interaction terms were used to investigate the effects of aspirin on MAP and UtA\u2010PI trajectories over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 798 participants in the aspirin group and 822 in the placebo group, there were 5951 MAP and 5942 UtA\u2010PI measurements. Trajectories of raw and multiples of the median (MoM) values of MAP did not differ significantly between the two groups (MAP MoM analysis:\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value for treatment by gestational age interaction, 0.340). In contrast, trajectories of raw and MoM values of UtA\u2010PI showed a significantly steeper decline in the aspirin group than in the placebo group, with the difference mainly driven by a more pronounced reduction before 20\u2009weeks of gestation (UtA\u2010PI MoM analysis:\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value for treatment by gestational age interaction, 0.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In women at increased risk of preterm pre\u2010eclampsia, 150\u2009mg\/day aspirin initiated in the first trimester does not affect MAP but is associated with a significant decrease in mean UtA\u2010PI, particularly before 20\u2009weeks of gestation. \u00a9 2023 The Authors.\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.26222","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T12:24:15Z","timestamp":1681475055000},"page":"691-697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["<scp>ASPRE<\/scp>\n                    trial: effects of aspirin on mean arterial blood pressure and uterine artery pulsatility index trajectories in pregnancy"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2263-3592","authenticated-orcid":false,"given":"D. L.","family":"Rolnik","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5856-6072","authenticated-orcid":false,"given":"A.","family":"Syngelaki","sequence":"additional","affiliation":[{"name":"Fetal Medicine Research Institute King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"O'Gorman","sequence":"additional","affiliation":[{"name":"Coombe Women and Infants University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Wright","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3944-4130","authenticated-orcid":false,"given":"L. C.","family":"Poon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Chinese University of Hong Kong  Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. H.","family":"Nicolaides","sequence":"additional","affiliation":[{"name":"Fetal Medicine Research Institute King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19039"},{"issue":"103","key":"e_1_2_8_3_1","first-page":"e1","article-title":"Competing risks model in screening for preeclampsia by maternal factors and biomarkers at 11\u201013\u2009weeks gestation","volume":"214","author":"O'Gorman N","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17455"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704559"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17448"},{"issue":"580","key":"e_1_2_8_7_1","first-page":"e1","article-title":"Aspirin delays the development of preeclampsia","volume":"220","author":"Wright D","year":"2019","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2016.08.010"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2020.1786048"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2018.04.003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641950109152635"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-011801"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14783"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14789"},{"key":"e_1_2_8_15_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Development Core Team","year":"2022"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_8_17_1","unstructured":"WoodS ScheiplF.gamm4: Generalized additive mixed models using mgcv and lme4. 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