{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T21:51:06Z","timestamp":1778709066899,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1S31720N"],"award-info":[{"award-number":["1S31720N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["T002618N"],"award-info":[{"award-number":["T002618N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001279","name":"Great Ormond Street Hospital Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001279","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To develop a core set of prenatal and neonatal outcomes for clinical studies evaluating perinatal interventions for congenital diaphragmatic hernia, using a validated consensus\u2010building method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An international steering group comprising 13 leading maternal\u2013fetal medicine specialists, neonatologists, pediatric surgeons, patient representatives, researchers and methodologists guided the development of this core outcome set. Potential outcomes were collected through a systematic review of the literature and entered into a two\u2010round online Delphi survey. A call was made for stakeholders with experience of congenital diaphragmatic hernia to review the list and score outcomes based on their perceived relevance. Outcomes that fulfilled the consensus criteria defined <jats:italic>a priori<\/jats:italic> were discussed subsequently in online breakout meetings. Results were reviewed in a consensus meeting, during which the core outcome set was defined. Finally, the definitions, measurement methods and aspirational outcomes were defined in online and in\u2010person definition meetings by a selection of 45 stakeholders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 221 stakeholders participated in the Delphi survey and 198 completed both rounds. Fifty outcomes met the consensus criteria and were discussed and rescored by 78 stakeholders in the breakout meetings. During the consensus meeting, 93 stakeholders agreed eventually on eight outcomes, which constituted the core outcome set. Maternal and obstetric outcomes included maternal morbidity related to the intervention and gestational age at delivery. Fetal outcomes included intrauterine demise, interval between intervention and delivery and change in lung size <jats:italic>in utero<\/jats:italic> around the time of the intervention. Neonatal outcomes included neonatal mortality, pulmonary hypertension and use of extracorporeal membrane oxygenation. Definitions and measurement methods were formulated by 45 stakeholders, who also added three aspirational outcomes: duration of invasive ventilation, duration of oxygen supplementation and use of pulmonary vasodilators at discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We developed with relevant stakeholders a core outcome set for studies evaluating perinatal interventions in congenital diaphragmatic hernia. Its implementation should facilitate the comparison and combination of trial results, enabling future research to better guide clinical practice. \u00a9 2023 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.26235","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T20:48:03Z","timestamp":1682542083000},"page":"374-382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Core outcome set for perinatal interventions for congenital diaphragmatic hernia"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8372-6434","authenticated-orcid":false,"given":"S.","family":"Vergote","sequence":"first","affiliation":[{"name":"Department of Development and Regeneration, Cluster Woman and Child Biomedical Sciences, KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. R.","family":"De Bie","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration, Cluster Woman and Child Biomedical Sciences, KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M. N.","family":"Duffy","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bosteels","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration, Cluster Woman and Child Biomedical Sciences, KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Benachi","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2013Obst\u00e9trique H\u00f4pital Antoine\u2013B\u00e9cl\u00e8re, AP\u2013HP  Clamart France"},{"name":"Centre de R\u00e9f\u00e9rence Maladies Rares Hernie de Coupole Diaphragmatique H\u00f4pital Antoine\u2013B\u00e9cl\u00e8re, AP\u2013HP  Clamart France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Power","sequence":"additional","affiliation":[{"name":"The Congenital Diaphragmatic Hernia Charity (CDH UK)  King's Lynn UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Meijer","sequence":"additional","affiliation":[{"name":"PlatformCHD  Arnhem The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. L.","family":"Hedrick","sequence":"additional","affiliation":[{"name":"Department of Surgery Children's Hospital of Philadelphia  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics Texas Children's Hospital and Baylor College of Medicine  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. K. 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