{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:08:15Z","timestamp":1773706095983,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the national prevalence and prenatal detection rate (DR) of major congenital heart disease (mCHD) in twin pregnancies without twin\u2010to\u2010twin transfusion syndrome (TTTS)\u2010associated CHD in a Danish population following a standardized prenatal screening program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a national registry\u2010based study of data collected prospectively over a 10\u2010year period. In Denmark, all women with a twin pregnancy are offered standardized screening and surveillance programs in addition to first\u2010 and second\u2010trimester screening for aneuploidies and malformation, respectively: monochorionic (MC) twins every 2\u2009weeks from gestational week\u200915 and dichorionic (DC) twins every 4\u2009weeks from week\u200918. The data were retrieved from the Danish Fetal Medicine Database and included all twin pregnancies from 2009\u20132018, in which at least one fetus had a pre\u2010 and\/or postnatal mCHD diagnosis. mCHD was defined as CHD requiring surgery within the first year of life, excluding ventricular septal defects. All pregnancy data were pre\u2010 and postnatally validated in the local patient files at the four tertiary centers covering the entire country.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 60 cases from 59 twin pregnancies were included. The prevalence of mCHD was 4.6 (95%\u2009CI, 3.5\u20136.0) per 1000 twin pregnancies (1.9 (95%\u2009CI, 1.3\u20132.5) per 1000 live births). The prevalences for DC and MC were 3.6 (95%\u00a0CI, 2.6\u20135.0) and 9.2 (95%\u00a0CI, 5.8\u201313.7) per 1000 twin pregnancies, respectively. The national prenatal DR of mCHD in twin pregnancies for the entire period was 68.3%. The highest DRs were in cases with univentricular hearts (100%) and the lowest with aortopulmonary window, total anomalous pulmonary venous return, Ebstein's anomaly, aortic valve stenosis and coarctation of the aorta (0\u201325%). Mothers of children with prenatally undetected mCHD had a significantly higher body mass index (BMI) compared to mothers of children with a prenatally detected mCHD (median, 27\u2009kg\/m<jats:sup>2<\/jats:sup> and 23\u2009kg\/m<jats:sup>2<\/jats:sup>, respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of mCHD in twins was 4.6 per 1000 pregnancies and was higher in MC than DC pregnancies. The prenatal DR of mCHD in twin pregnancies was 68.3%. Maternal BMI was higher in cases of prenatally undetected mCHD. \u00a9 2023 The Authors. <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.26249","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T12:59:50Z","timestamp":1684241990000},"page":"681-687","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence and detection rate of major congenital heart disease in twin pregnancies in Denmark"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4457-9822","authenticated-orcid":false,"given":"M.","family":"Bouazzi","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Center of Fetal Medicine and Pregnancy Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine Copenhagen University Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. E. S.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Center of Fetal Medicine and Pregnancy Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Krusenstjerna\u2010Hafstr\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. K.","family":"Ekelund","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Center of Fetal Medicine and Pregnancy Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine Copenhagen University Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. N.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Sandager","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"},{"name":"Department of Clinical Medicine, Center for Fetal Diagnostics Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Sperling","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Steensberg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Sundberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Center of Fetal Medicine and Pregnancy Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. G.","family":"Vejlstrup","sequence":"additional","affiliation":[{"name":"The Heart Centre, Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8517-4082","authenticated-orcid":false,"given":"O. B. 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