{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:30:25Z","timestamp":1789122625235,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004060","name":"Preeclampsia Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","award":["SLS\u2010934559"],"award-info":[{"award-number":["SLS\u2010934559"]}],"id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015988","name":"Norman Beischer Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015988","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess whether coexisting fetal growth restriction (FGR) influences pregnancy latency among women with preterm pre\u2010eclampsia undergoing expectant management. Secondary outcomes assessed were indication for delivery, mode of delivery and rate of serious adverse maternal and perinatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a secondary analysis of the Pre\u2010eclampsia Intervention (PIE) and the Pre\u2010eclampsia Intervention 2 (PI2) trial data. These randomized controlled trials evaluated whether esomeprazole and metformin could prolong gestation of women diagnosed with pre\u2010eclampsia between 26 and 32\u2009weeks of gestation undergoing expectant management. Delivery indications were deteriorating maternal or fetal status, or reaching 34\u2009weeks' gestation. FGR (defined by Delphi consensus) at the time of pre\u2010eclampsia diagnosis was examined as a predictor of outcome. Only placebo data from PI2 were included, as the trial showed that metformin use was associated with prolonged gestation. All outcome data were collected prospectively from diagnosis of pre\u2010eclampsia to 6\u2009weeks after the expected due date.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 202 women included, 92 (45.5%) had FGR at the time of pre\u2010eclampsia diagnosis. Median pregnancy latency was 6.8\u2009days in the FGR group and 15.3\u2009days in the control group (difference 8.5\u2009days; adjusted 0.49\u2010fold change (95%\u2009CI, 0.33\u20130.74);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). FGR pregnancies were less likely to reach 34\u2009weeks' gestation (12.0%\n                      <jats:italic>vs<\/jats:italic>\n                      30.9%; adjusted relative risk (aRR), 0.44 (95%\u2009CI, 0.23\u20130.83)) and more likely to be delivered for suspected fetal compromise (64.1%\n                      <jats:italic>vs<\/jats:italic>\n                      36.4%; aRR, 1.84 (95%\u2009CI, 1.36\u20132.47)). More women with FGR underwent a prelabor emergency Cesarean section (66.3%\n                      <jats:italic>vs<\/jats:italic>\n                      43.6%; aRR, 1.56 (95%\u2009CI, 1.20\u20132.03)) and were less likely to have a successful induction of labor (4.3%\n                      <jats:italic>vs<\/jats:italic>\n                      14.5%; aRR, 0.32 (95%\u2009CI, 0.10\u20131.00)), compared to those without FGR. The rate of maternal complications did not differ significantly between the two groups. FGR was associated with a higher rate of infant death (14.1%\n                      <jats:italic>vs<\/jats:italic>\n                      4.5%; aRR, 3.26 (95%\u2009CI, 1.08\u20139.81)) and need for intubation and mechanical ventilation (15.2%\n                      <jats:italic>vs<\/jats:italic>\n                      5.5%; aRR, 2.97 (95%\u2009CI, 1.11\u20137.90)).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      FGR is commonly present in women with early preterm pre\u2010eclampsia and outcome is poorer. FGR is associated with shorter pregnancy latency, more emergency Cesarean deliveries, fewer successful inductions and increased rates of neonatal morbidity and mortality. \u00a9 2023 The Authors.\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.26282","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T14:28:16Z","timestamp":1686234496000},"page":"660-667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Impact of fetal growth restriction on pregnancy outcome in women undergoing expectant management for preterm pre\u2010eclampsia"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0406-8964","authenticated-orcid":false,"given":"C. A.","family":"Cluver","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Stellenbosch University and Tygerberg Hospital  Cape Town South Africa"},{"name":"Mercy Perinatal Mercy Hospital for Women  Melbourne VI Australia"},{"name":"Translational Obstetrics Group University of Melbourne  Melbourne VI Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Bergman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Stellenbosch University and Tygerberg Hospital  Cape Town South Africa"},{"name":"Department of Obstetrics and Gynecology Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bergkvist","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9447-663X","authenticated-orcid":false,"given":"H.","family":"Imberg","sequence":"additional","affiliation":[{"name":"Statistiska Konsultgruppen  Gothenburg Sweden"},{"name":"Department of Mathematical Sciences Chalmers University of Technology and University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4703-629X","authenticated-orcid":false,"given":"L.","family":"Geerts","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Stellenbosch University and Tygerberg Hospital  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. R.","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Stellenbosch University and Tygerberg Hospital  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8337-550X","authenticated-orcid":false,"given":"B. W.","family":"Mol","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Monash School of Medicine Monash University  Melbourne VI Australia"},{"name":"Aberdeen Centre for Women's Health Research, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition University of Aberdeen  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tong","sequence":"additional","affiliation":[{"name":"Mercy Perinatal Mercy Hospital for Women  Melbourne VI Australia"},{"name":"Translational Obstetrics Group University of Melbourne  Melbourne VI Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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