{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T05:19:45Z","timestamp":1768972785495,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["2013T084"],"award-info":[{"award-number":["2013T084"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To develop a prediction model for the development of hypertension in the decade following pre\u2010eclampsia in women who were normotensive shortly after pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This\u00a0was a longitudinal cohort study of formerly pre\u2010eclamptic women attending a university hospital in The Netherlands between 1996 and 2019. We developed a prediction model for incident hypertension using multivariable logistic regression analysis. The model was validated internally using bootstrapping techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 259 women, 185 (71%) were normotensive at the first cardiovascular assessment, at a median of 10 (interquartile range (IQR), 6\u201324) months after a pre\u2010eclamptic pregnancy, of whom 49 (26%) had developed hypertension by the second visit, at a median of 11 (IQR, 6\u201314) years postpartum. The prediction model, based on birth\u2010weight centile, mean arterial pressure, total cholesterol, left ventricular mass index and left ventricular ejection fraction, had good\u2010to\u2010excellent discriminative ability, with an area under the receiver\u2010operating\u2010characteristics curve (AUC) of 0.82 (95%\u2009CI, 0.75\u20130.89) and an optimism\u2010corrected AUC of 0.80. The sensitivity and specificity of our model to predict hypertension were 98% and 34%, respectively, and positive and negative predictive values were 35% and 98%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on five variables, we developed a good\u2010to\u2010excellent predictive tool to identify incident hypertension following pre\u2010eclampsia in women who were normotensive shortly after pregnancy. After external validation, this model could have considerable clinical utility in tackling the cardiovascular legacy of pre\u2010eclampsia. \u00a9 2023 The Authors. <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.26284","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T18:29:46Z","timestamp":1686248986000},"page":"531-539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prediction model for hypertension in first decade after pre\u2010eclampsia in initially normotensive women"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7591-0074","authenticated-orcid":false,"given":"M. C. E.","family":"Hooijschuur","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Maastricht University Medical Centre and GROW  Maastricht The Netherlands"},{"name":"Department of Internal Medicine Erasmus Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. B. N. J.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Maastricht University Medical Centre and GROW  Maastricht The Netherlands"},{"name":"Cardiovascular Research Institute Maastricht (CARIM)  Maastricht The Netherlands"},{"name":"Department of Cardiology Maastricht University Medical Centre  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2689-8528","authenticated-orcid":false,"given":"E. G.","family":"Mulder","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Maastricht University Medical Centre and GROW  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Kroon","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Maastricht (CARIM)  Maastricht The Netherlands"},{"name":"Department of Internal Medicine Maastricht University Medical Centre  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M. J.","family":"Meijers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Maastricht University Medical Centre and GROW  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Brugts","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus MC University Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. C. T.","family":"van Bussel","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine and Public Health Research Institute (CAPHRI) Maastricht University Medical Centre  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M. J.","family":"van Kuijk","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Medical Technology Assessment Maastricht University Medical Centre  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E. 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