{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:59:20Z","timestamp":1792457960097,"version":"4.5.0"},"reference-count":102,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report on the occurrence of urological complications in women undergoing Cesarean section for placenta accreta spectrum disorders (PAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MEDLINE, EMBASE and the Cochrane databases were searched electronically up to 1 November 2022. Studies reporting on the urological outcome of women undergoing Cesarean section for PAS were included. Two independent reviewers performed data extraction using a predefined protocol and assessed the risk of bias using the Newcastle\u2013Ottawa scale for observational studies, with disagreements resolved by consensus.The primary outcome was the overall occurrence of urological complications. Secondary outcomes were the occurrence of any cystotomy, intentional cystotomy, unintentional cystotomy, ureteral damage, ureteral fistula and vesicovaginal fistula. All outcomes were explored in the overall population of women undergoing surgery for PAS. In addition, we performed subgroup analyses according to the type of surgery (Cesarean hysterectomy, or conservative surgery or management), severity of PAS at histopathology (placenta accreta\/increta and placenta percreta), type of intervention (planned<jats:italic>vs<\/jats:italic>emergency) and number of cases per year. Random\u2010effects meta\u2010analyses of proportions were used to analyze the data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 62 studies included in the systematic review and 56 were included in the meta\u2010analysis. Urological complications occurred in 15.2% (95%\u2009CI, 12.9\u201317.7%) of cases. Cystotomy complicated 13.5% (95%\u2009CI, 9.7\u201317.9%) of surgical operations. Intentional cystotomy was required in 7.7% (95%\u2009CI, 6.5\u20139.1%) of cases, while unintentional cystotomy occurred in 7.2% (95%\u2009CI, 6.0\u20138.5%) of cases. Urological complications occurred in 19.4% (95%\u2009CI, 16.3\u201322.7%) of cases undergoing hysterectomy and 12.2% (95%\u2009CI, 7.5\u201317.8%) of those undergoing conservative treatment. In the subgroup analyses, urological complications occurred in 9.4% (95%\u2009CI, 5.4\u201314.4%) of women with placenta accreta\/increta and 38.5% (95%\u2009CI, 21.6\u201357.0%) of those described as having placenta percreta, and included mainly cystotomy (5.5% (95%\u2009CI, 0.6\u201315.1%) and 22.0% (95%\u2009CI, 5.4\u201345.5%), respectively). Urological complications occurred in 15.4% (95%\u2009CI, 8.1\u201324.6%) of cases undergoing a planned procedure and 24.6% (95%\u2009CI, 13.0\u201338.5%) of those undergoing an emergency intervention. In subanalysis of studies reporting on \u2265\u200912 cases per year, the incidence of urological complication was similar to that reported in the primary analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women undergoing surgery for PAS are at high risk of urological complication, mainly cystotomy. The incidence of these complications was particularly high in women described as having placenta percreta at birth and in those undergoing emergency surgical intervention. The high heterogeneity between the included studies highlights the need for a standardized protocol for the diagnosis of PAS to identify prenatal imaging signs associated with the increased risk of urological morbidity at delivery. \u00a9 2023 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.26299","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T11:55:12Z","timestamp":1688471712000},"page":"633-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Urological complications in women undergoing Cesarean section for placenta accreta spectrum disorders: systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"62","author":[{"given":"A.","family":"Lucidi","sequence":"first","affiliation":[{"name":"Center for Fetal Care and High\u2010Risk Pregnancy, Department of Obstetrics and Gynecology University of Chieti Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0925-7737","authenticated-orcid":false,"given":"E.","family":"Jauniaux","sequence":"additional","affiliation":[{"name":"EGA Institute for Women's Health, Faculty of Population Health Sciences University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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