{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T12:25:47Z","timestamp":1770467147823,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To ascertain whether abnormalities in neonatal head circumference and\/or body weight are associated with levels of angiogenic\/antiangiogenic factors in the maternal and cord blood of pregnancies with a congenital heart defect (CHD) and to assess whether the specific type of CHD influences this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a multicenter case\u2013control study of women carrying a fetus with major CHD. Recruitment was carried out between June 2010 and July 2018 at four tertiary care hospitals in Spain. Maternal venous blood was drawn at study inclusion and at delivery. Cord blood samples were obtained at birth when possible. Placental growth factor (PlGF), soluble fms\u2010like tyrosine kinase\u20101 (sFlt\u20101) and soluble endoglin (sEng) were measured in maternal and cord blood. Biomarker concentrations in the maternal blood were expressed as multiples of the median (MoM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PlGF, sFlt\u20101 and sEng levels were measured in the maternal blood in 237 cases with CHD and 260 healthy controls, and in the cord blood in 150 cases and 56 controls. Compared with controls, median PlGF MoM in maternal blood was significantly lower in the CHD group (0.959\n                      <jats:italic>vs<\/jats:italic>\n                      1.022;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001), while median sFlt\u20101\/PlGF ratio MoM was significantly higher (1.032\n                      <jats:italic>vs<\/jats:italic>\n                      0.974;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0085) and no difference was observed in sEng MoM (0.981\n                      <jats:italic>vs<\/jats:italic>\n                      1.011;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.4673). Levels of sFlt\u20101 and sEng were significantly higher in cord blood obtained from fetuses with CHD compared to controls (mean\u2009\u00b1\u2009standard error of the mean, 447\u2009\u00b1\u200951\n                      <jats:italic>vs<\/jats:italic>\n                      264\u2009\u00b1\u200920\u2009pg\/mL;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0470 and 8.30\u2009\u00b1\u20090.92\n                      <jats:italic>vs<\/jats:italic>\n                      5.69\u2009\u00b1\u20090.34 ng\/mL;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0430, respectively). Concentrations of sFlt\u20101 and the sFlt\u20101\/PlGF ratio in the maternal blood at study inclusion were associated negatively with birth weight and head circumference in the CHD group. The type of CHD anomaly (valvular, conotruncal or left ventricular outflow tract obstruction) did not appear to alter these findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pregnancies with fetal CHD have an antiangiogenic profile in maternal and cord blood. This imbalance is adversely associated with neonatal head circumference and birth weight. \u00a9 2023 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.27441","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T03:23:01Z","timestamp":1690773781000},"page":"214-221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Angiogenic imbalance in maternal and cord blood is associated with neonatal birth weight and head circumference in pregnancies with major fetal congenital heart defect"],"prefix":"10.1002","volume":"63","author":[{"given":"O.","family":"S\u00e1nchez","sequence":"first","affiliation":[{"name":"Women and Perinatal Health Research Group, Institut de Recerca (IR SANT PAU)  Barcelona Spain"},{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS\u2010SAMID) (RD21\/0012), Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Ribera","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Fetal Medicine Unit, Vic Hospitalary Consortium  Vic Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Hospital Universitari Son Ll\u00e0tzer  Palma de Mallorca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7379-9608","authenticated-orcid":false,"given":"E.","family":"Eixarch","sequence":"additional","affiliation":[{"name":"BCNatal, Hospital Cl\u00ednic of Barcelona and Hospital Sant Joan de D\u00e9u, Fetal Medicine Unit  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Antol\u00edn","sequence":"additional","affiliation":[{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS\u2010SAMID) (RD21\/0012), Instituto de Salud Carlos III  Madrid Spain"},{"name":"Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynaecology Hospital Universitario La Paz  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cruz\u2010Lemini","sequence":"additional","affiliation":[{"name":"Women and Perinatal Health Research Group, Institut de Recerca (IR SANT PAU)  Barcelona Spain"},{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS\u2010SAMID) (RD21\/0012), Instituto de Salud Carlos III  Madrid Spain"},{"name":"Department of Obstetrics and Gynaecology Fetal Medicine 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