{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:45:05Z","timestamp":1792788305790,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T00:00:00Z","timestamp":1701475200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Epidemiological studies have established that women with pre\u2010eclampsia (PE) are at increased long\u2010term cardiovascular risk. Mild cardiac functional changes have been documented during pregnancy in women with PE, but their evolution from presentation to the postpartum period remains poorly defined. The aim of this study was to assess biventricular cardiovascular indices using novel and sensitive two\u2010dimensional and three\u2010dimensional (3D) echocardiographic modalities in pregnancy and to track alterations in both risk factors and cardiovascular indices in the postpartum period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 59 women with PE were examined at 34 (interquartile range, 31\u201337)\u2009weeks' gestation and at 2\u20133\u2009days, 3\u2009months and 6\u2009months postpartum. During pregnancy, 118 women with a normotensive pregnancy were also recruited as controls. Biventricular ejection fraction and left ventricular mass were measured by 3D echocardiography. Biventricular global longitudinal strain and strain of the left atrium were assessed using speckle\u2010tracking imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In women with PE, compared with controls, there was lower left ventricular diastolic function (left atrial reservoir strain, 44.1%\n                      <jats:italic>vs<\/jats:italic>\n                      49.2%) and increased left ventricular mass index (148\n                      <jats:italic>vs<\/jats:italic>\n                      128 g\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), but there was no significant difference in right ventricular functional indices. These alterations in cardiac indices were mostly explained by differences in maternal risk factors. In the postpartum period, most cardiac indices improved by 3\u2009months. Multivariable linear mixed\u2010model analysis demonstrated that this improvement was mostly attributed to reduction in weight and blood pressure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In women with PE, there is postpartum improvement in cardiac functional and structural indices in parallel with improvement in their risk factor profile. \u00a9 2023 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.27442","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:59:31Z","timestamp":1691456371000},"page":"852-859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Three\u2010dimensional echocardiography and strain cardiac imaging in women with pre\u2010eclampsia with follow\u2010up to 6\u2009months postpartum"],"prefix":"10.1002","volume":"62","author":[{"given":"A. M.","family":"Company Calabuig","sequence":"first","affiliation":[{"name":"Hospital Clinico Universitario Virgen de la Arrixaca, Institute for Biomedical Research of Murcia, IMIB\u2010Arrixaca  Murcia Spain"},{"name":"Harris Birthright Research Centre for Fetal Medicine Fetal Medicine Research Institute, King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Nunez","sequence":"additional","affiliation":[{"name":"Hospital Clinico Universitario Virgen de la Arrixaca, Institute for Biomedical Research of Murcia, IMIB\u2010Arrixaca  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Georgiopoulos","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. H.","family":"Nicolaides","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine Fetal Medicine Research Institute, King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Charakida","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine Fetal Medicine Research Institute, King's College Hospital  London UK"},{"name":"School of Biomedical Engineering and Imaging Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"De Paco Matallana","sequence":"additional","affiliation":[{"name":"Hospital Clinico Universitario Virgen de la Arrixaca, Institute for Biomedical Research of Murcia, IMIB\u2010Arrixaca  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.116.003497"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.021733"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17084"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06667"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23568"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.10.033"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.14643"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16545"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2018.06.015"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15983"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.176537"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003018"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335366"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeu184"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2017.11.017"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2020.03.021"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/14779072.2019.1697234"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23666"},{"key":"e_1_2_8_21_1","first-page":"QC01\u20133","article-title":"Maternal cardiac diastolic dysfunction by doppler echocardiography in women with preeclampsia","volume":"10","author":"Muthyala T","year":"2016","journal-title":"Journal of clinical and diagnostic research: J Clin Diagn Res"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-015-0628-8"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2021.08.003"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2015.12.004"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.04.014"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.5812\/acvi.16081"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-015-9520-9"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.13094"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00966.2001"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-021-02210-6"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.834325"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17171"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23745"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.04.013"}],"container-title":["Ultrasound in Obstetrics &amp; 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