{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T07:00:02Z","timestamp":1781074802998,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Twin pregnancy is associated with increased perinatal mortality and morbidity, but long\u2010term neurodevelopmental outcome remains underinvestigated. The primary objective of this study was to investigate the incidence of adverse neurodevelopment after 1\u2009year of age in complicated monochorionic diamniotic (MCDA) twin pregnancies compared with uncomplicated twin pregnancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective cohort study conducted at St George's University Hospital NHS Foundation Trust, London, UK. Women with a twin pregnancy culminating in at least one surviving child, aged between 12 and 60 months (corrected for prematurity) at the time of assessment, were invited to complete the relevant Ages and Stages Questionnaire\u00ae version 3 (ASQ\u20103) test. The two study groups were: (1) complicated MCDA twin pregnancies, including those with twin\u2013twin transfusion syndrome, twin anemia\u2013polycythemia sequence, selective fetal growth restriction, twin reversed arterial perfusion sequence and\/or single intrauterine demise; and (2) uncomplicated MCDA and dichorionic diamniotic twin pregnancies. The primary outcome measure was an abnormal ASQ\u20103 score, defined as a score of more than 2 SD below the mean in any one of the five domains. Mixed\u2010effects multivariable logistic regression analysis was performed to determine whether a complicated MCDA twin pregnancy was associated independently with an abnormal ASQ\u20103 score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 174 parents who completed the questionnaire for one or both twins; therefore, 327 ASQ\u20103 questionnaires were available for analysis. Of those, 117 (35.8%) were complicated MCDA twin pregnancies and 210 (64.2%) were controls. The overall rate of an abnormal ASQ\u20103 score in children born of a complicated MCDA twin pregnancy was nearly double that of those from uncomplicated twin pregnancies (14.5%\n                      <jats:italic>vs<\/jats:italic>\n                      7.6%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.056). Children born of a complicated MCDA twin pregnancy had a significantly higher rate of impairment in the gross\u2010motor domain compared with the control group (8.5%\n                      <jats:italic>vs<\/jats:italic>\n                      2.9%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.031). Complicated MCDA twin pregnancies that underwent prenatal intervention had a significantly higher rate of abnormal ASQ\u20103 score compared with those that did not undergo prenatal intervention (28.1%\n                      <jats:italic>vs<\/jats:italic>\n                      1.7%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). On multilevel logistic regression analysis, complicated MCDA twin pregnancy was an independent predictor of abnormal ASQ\u20103 score (adjusted odds ratio, 3.28 (95% CI, 3.27\u20133.29);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study demonstrates that survivors of complicated MCDA twin pregnancies have a higher rate of adverse neurodevelopmental outcome, independently of prematurity. Long\u2010term neurodevelopmental follow\u2010up in these pregnancies can ensure timely and optimal management of those affected. \u00a9 2023 The Authors.\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.27448","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T01:19:48Z","timestamp":1691457588000},"page":"189-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Neurodevelopmental outcome in complicated twin pregnancy: prospective observational study"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2329-4470","authenticated-orcid":false,"given":"S.","family":"Prasad","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit St George's University Hospitals NHS Foundation Trust, University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Beg","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit St George's University Hospitals NHS Foundation Trust, University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Badran","sequence":"additional","affiliation":[{"name":"NHS Greater Glasgow and Clyde  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Masciullo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Cristo Re Hospital  Rome 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