{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:58:15Z","timestamp":1787961495254,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To validate and extend a model incorporating maternal ophthalmic artery Doppler at 35\u201337\u2009weeks' gestation in the prediction of subsequent development of pre\u2010eclampsia (PE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a prospective validation study of screening for PE (defined according to the 2019 American College of Obstetricians and Gynecologists criteria) by maternal ophthalmic artery peak systolic velocity (PSV) ratio in 6746 singleton pregnancies undergoing routine care at 35\u2009+\u20090 to 36\u2009+\u20096\u2009weeks' gestation (validation dataset). Additionally, the data from the validation dataset were combined with those of 2287 pregnancies that were previously used for development of the model (training dataset), and the combined data were used to update the original model parameters. The competing\u2010risks model was used to estimate the individual patient\u2010specific risk of delivery with PE at any time and within\u20093\u2009weeks from assessment by a combination of maternal demographic characteristics and medical history with PSV ratio alone and in combination with the established PE biomarkers of mean arterial pressure (MAP), uterine artery pulsatility index (UtA\u2010PI), serum placental growth factor (PlGF) and serum soluble fms\u2010like tyrosine kinase\u20101 (sFlt\u20101). We evaluated the predictive performance of the model by examining, first, the ability to discriminate between the PE and non\u2010PE groups using the area under the receiver\u2010operating\u2010characteristics curve and the detection rate (DR) at fixed screen\u2010positive (SPR) and false\u2010positive rates of 10% and, second, calibration by measuring the calibration slope and calibration\u2010in\u2010the\u2010large. McNemar's test was used to compare the performance of screening by a biophysical test (maternal factors, MAP, UtA\u2010PI and PSV ratio)\n                      <jats:italic>vs<\/jats:italic>\n                      a biochemical test (maternal factors, PlGF and sFlt\u20101), low PlGF concentration (&lt;\u200910\n                      <jats:sup>th<\/jats:sup>\n                      percentile) or high sFlt\u20101\/PlGF concentration ratio (&gt;\u200990\n                      <jats:sup>th<\/jats:sup>\n                      percentile).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the validation dataset, the performance of screening by maternal factors and PSV ratio for delivery with PE within 3\u2009weeks and at any time after assessment was consistent with that in the training dataset, and there was good agreement between the predicted and observed incidence of PE. In the combined data from the training and validation datasets, good prediction for PE was achieved in screening by a combination of maternal factors, MAP, UtA\u2010PI, PlGF, sFlt\u20101 and PSV ratio, with a DR, at a 10% SPR, of 85.0% (95%\u2009CI, 76.5\u201391.4%) for delivery with PE within 3\u2009weeks and 65.7% (95%\u2009CI, 59.2\u201371.7%) for delivery with PE at any time after assessment. The performance of a biophysical test was superior to that of screening by low PlGF concentration or high sFlt\u20101\/PlGF concentration ratio but not significantly different from the performance of a biochemical test combining maternal factors with PlGF and sFlt\u20101 for both PE within 3\u2009weeks and PE at any time after assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Maternal ophthalmic artery PSV ratio at 35\u201337\u2009weeks' gestation in combination with other biomarkers provides effective prediction of subsequent development of PE. \u00a9 2023 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.27464","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T15:44:11Z","timestamp":1692891851000},"page":"230-236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Ophthalmic artery Doppler at 36 weeks' gestation in prediction of pre\u2010eclampsia: validation and update of previous model"],"prefix":"10.1002","volume":"63","author":[{"given":"T.","family":"Mansukhani","sequence":"first","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine, King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wright","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0151-1932","authenticated-orcid":false,"given":"A.","family":"Arechvo","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine, King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Laich","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine, King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine, King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Charakida","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine, King's College Hospital  London UK"},{"name":"School of Biomedical Engineering and Imaging Sciences, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. H.","family":"Nicolaides","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine, King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23665"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-016-0842-x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.24914"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23528"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22184"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23517"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h5527"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335366"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)00946-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1975.tb00710.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1994.04010034.x"},{"key":"e_1_2_8_13_1","first-page":"1","article-title":"202: Gestational Hypertension and Preeclampsia","volume":"133","author":"American College of Obstetricians and Gynecologists Practice Bulletin No.","year":"2019","journal-title":"Obstet Gynecol"},{"issue":"62","key":"e_1_2_8_14_1","first-page":"e1","article-title":"Competing risks model in screening for preeclampsia by maternal characteristics and medical history","volume":"213","author":"Wright D","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_8_15_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2020"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-77"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.11.1247"},{"issue":"103","key":"e_1_2_8_18_1","first-page":"e1","article-title":"Competing risks model in screening for preeclampsia by maternal factors and biomarkers at 11\u201013\u2009weeks gestation","volume":"214","author":"O'Gorman N","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19112"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704559"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23742"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.20565"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19111"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003215"},{"issue":"58","key":"e_1_2_8_25_1","first-page":"e1","article-title":"The sFlt\u20101\/PlGF ratio in different types of hypertensive pregnancy disorders and its prognostic potential in preeclamptic patients","volume":"206","author":"Verlohren S","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414838"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641955.2016.1141214"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.27464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T08:30:26Z","timestamp":1763454626000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.27464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,12]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/uog.27464"],"URL":"https:\/\/doi.org\/10.1002\/uog.27464","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,12]]},"assertion":[{"value":"2023-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}