{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:45:03Z","timestamp":1792788303342,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2024,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n The maternal cardiovascular system of women with hypertensive disorders of pregnancy (HDP) can be impaired, with higher rates of left ventricular (LV) remodeling and diastolic dysfunction compared to those with normotensive pregnancy. The primary objective of this prospective study was to correlate cardiac indices obtained by transthoracic echocardiography (TTE) and circulating angiogenic markers, such as soluble fms\u2010like tyrosine kinase\u20101 (sFlt\u20101) and placental growth factor (PlGF).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this study, 95 women with a pregnancy complicated by HDP and a group of 25 with an uncomplicated pregnancy at term underwent TTE and blood tests to measure sFlt\u20101 and PlGF during the peripartum period (before delivery or within a week of giving birth). Spearman's rank correlation was used to derive correlation coefficients between biomarkers and cardiac indices in the HDP and control populations.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The HDP group included 61 (64.2%) pre\u2010eclamptic patients and, among them, 42 (68.9%) delivered before 37\u2009weeks' gestation. Twelve women with HDP (12.6%) underwent blood sampling and TTE after delivery, and, as they showed significantly lower levels of angiogenic markers, they were excluded from the analysis. There was a correlation between sFlt\u20101 and LV mass index (LVMI) (\n r<\/jats:italic>\n \u2009=\u20090.246;\n P<\/jats:italic>\n \u2009=\u20090.026) and early diastolic mitral inflow velocity (E) and early diastolic mitral annular velocity (e\u2032) ratio (\n r<\/jats:italic>\n \u2009=\u20090.272;\n P<\/jats:italic>\n \u2009=\u20090.014) in the HDP group (\n n<\/jats:italic>\n \u2009=\u200983), while in the controls, sFlt\u20101 showed a correlation with relative wall thickness (\n r<\/jats:italic>\n \u2009=\u20090.409;\n P<\/jats:italic>\n \u2009=\u20090.043), lateral e\u2032 (\n r<\/jats:italic>\n \u2009=\u2009\u22120.562;\n P<\/jats:italic>\n \u2009=\u20090.004) and E\/e\u2032 ratio (\n r<\/jats:italic>\n \u2009=\u20090.417;\n P<\/jats:italic>\n \u2009=\u20090.042). PlGF correlated with LVMI (\n r<\/jats:italic>\n \u2009=\u2009\u22120.238;\n P<\/jats:italic>\n \u2009=\u20090.031) in HDP patients and with lateral e\u2032 (\n r<\/jats:italic>\n \u2009=\u20090.466;\n P<\/jats:italic>\n \u2009=\u20090.022) in controls. sFlt\u20101\/PlGF ratio correlated with lateral e\u2032 (\n r<\/jats:italic>\n \u2009=\u2009\u22120.568;\n P<\/jats:italic>\n \u2009=\u20090.004) and E\/e\u2032 ratio (\n r<\/jats:italic>\n \u2009=\u20090.428;\n P<\/jats:italic>\n \u2009=\u20090.037) in controls and with LVMI (\n r<\/jats:italic>\n \u2009=\u20090.252;\n P<\/jats:italic>\n \u2009=\u20090.022) and E\/e\u2032 ratio (\n r<\/jats:italic>\n \u2009=\u20090.269;\n P<\/jats:italic>\n \u2009=\u20090.014) in HDP.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Although the current data are not able to infer causality, they confirm the intimate relationship between the maternal cardiovascular system and angiogenic markers that are used both to diagnose and indicate the severity of HDP. \u00a9 2023 The Authors.\n Ultrasound in Obstetrics & Gynecology<\/jats:italic>\n published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/uog.27474","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T05:19:12Z","timestamp":1694063952000},"page":"206-213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Angiogenic markers and maternal echocardiographic indices in women with hypertensive disorders of pregnancy"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3991-9308","authenticated-orcid":false,"given":"V.","family":"Giorgione","sequence":"first","affiliation":[{"name":"Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute St George's University of London London UK"},{"name":"Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Di Fabrizio","sequence":"additional","affiliation":[{"name":"Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute St George's University of London London UK"},{"name":"Division of Systems Medicine, School of Medicine University of Dundee Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Giallongo","sequence":"additional","affiliation":[{"name":"Intensive Care National Audit & Research Centre London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2802-7670","authenticated-orcid":false,"given":"A.","family":"Khalil","sequence":"additional","affiliation":[{"name":"Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute St George's University of London London UK"},{"name":"Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"O'Driscoll","sequence":"additional","affiliation":[{"name":"Department of Cardiology St George's University Hospitals NHS Foundation Trust London UK"},{"name":"School of Psychology and Life Sciences Canterbury Christ Church University Kent UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Whitley","sequence":"additional","affiliation":[{"name":"Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute St George's University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Immunoassay Biomarker Core Laboratory, School of Medicine University of Dundee Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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