{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:55:20Z","timestamp":1786978520118,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2024,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n \n Blood\u2010oxygen\u2010level\u2010dependent (BOLD) magnetic resonance imaging (MRI) facilitates the non\u2010invasive\n in\u2010vivo<\/jats:italic>\n evaluation of placental oxygenation. The aims of this study were to identify and quantify a relative BOLD effect in response to hyperoxia in the human placenta and to compare it between pregnancies with and those without fetal growth restriction (FGR).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was a prospective multicenter study (NCT02238301) of 19 pregnancies with FGR (estimated fetal weight (EFW) on ultrasound <\u20095\n th<\/jats:sup>\n centile) and 75 non\u2010FGR pregnancies (controls) recruited at two centers in Paris, France. Using a 1.5\u2010Tesla MRI system, the same multi\u2010echo gradient\u2010recalled echo (GRE) sequences were performed at both centers to obtain placental T2* values at baseline and in hyperoxic conditions. The relative BOLD effect was calculated according to the equation 100\u2009\u00d7\u2009(hyperoxic T2*\u2009\u2212\u2009baseline T2*)\/baseline T2*. Baseline T2* values and relative BOLD effect were compared according to EFW (FGR\n vs<\/jats:italic>\n non\u2010FGR), presence\/absence of Doppler anomalies and birth weight (small\u2010for\u2010gestational age (SGA)\n vs<\/jats:italic>\n non\u2010SGA).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We observed a relative BOLD effect in response to hyperoxia in the human placenta (median, 33.8% (interquartile range (IQR), 22.5\u201348.0%)). The relative BOLD effect did not differ significantly between pregnancies with and those without FGR (median, 34.4% (IQR, 24.1\u201348.5%)\n vs<\/jats:italic>\n 33.7% (22.7\u201347.4%);\n P\u2009=<\/jats:italic>\n \u00a00.95). Baseline T2*\n Z\u2010<\/jats:italic>\n score adjusted for gestational age at MRI was significantly lower in FGR pregnancies compared with non\u2010FGR pregnancies (median, \u22121.27 (IQR, \u22124.87 to \u22120.10)\n vs<\/jats:italic>\n 0.33 (IQR, \u22120.81 to 1.02);\n P\u2009=<\/jats:italic>\n \u00a00.001). Baseline T2*\n Z\u2010<\/jats:italic>\n score was also significantly lower in those pregnancies that subsequently delivered a SGA neonate (\n n\u2009=<\/jats:italic>\n \u00a023) compared with those that delivered a non\u2010SGA neonate (\n n\u2009=<\/jats:italic>\n \u00a062) (median, \u22120.75 (IQR, \u22123.48 to 0.29)\n vs<\/jats:italic>\n 0.35 (IQR, \u22120.79 to 1.05);\n P\u2009=<\/jats:italic>\n \u00a00.01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Our study confirms a BOLD effect in the human placenta and that baseline T2* values are significantly lower in pregnancies with FGR. Further studies are needed to evaluate whether such parameters may detect placental insufficiency before it has a clinical impact on fetal growth. \u00a9 2023 The Authors.\n Ultrasound in Obstetrics & Gynecology<\/jats:italic>\n published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/uog.27496","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T01:57:58Z","timestamp":1695607078000},"page":"472-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Placental\n T2<\/scp>\n * and\n BOLD<\/scp>\n effect in response to hyperoxia in normal and growth\u2010restricted pregnancies: multicenter cohort study"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4577-7759","authenticated-orcid":false,"given":"M.","family":"Jacquier","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Department H\u00f4pital Necker\u2010Enfants Malades AP\u2010HP Paris France"},{"name":"EA FETUS 7328 and LUMIERE Unit Universit\u00e9 de Paris\u2010Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3302-416X","authenticated-orcid":false,"given":"G.","family":"Chalouhi","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department H\u00f4pital Necker\u2010Enfants Malades AP\u2010HP Paris France"},{"name":"EA FETUS 7328 and LUMIERE Unit Universit\u00e9 de Paris\u2010Cit\u00e9 Paris France"},{"name":"Centre SFFERe (Sp\u00e9cialistes F\u0153tus, Femme Enceinte et Reproduction), Boulogne\u2010Billancourt France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Marquant","sequence":"additional","affiliation":[{"name":"Clinical Unit Research\/Clinic Investigation Center Paris Descartes University, H\u00f4pital Necker\u2010Enfants Malades AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Bussieres","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department H\u00f4pital Necker\u2010Enfants Malades AP\u2010HP Paris France"},{"name":"EA FETUS 7328 and LUMIERE Unit Universit\u00e9 de Paris\u2010Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Grevent","sequence":"additional","affiliation":[{"name":"EA FETUS 7328 and LUMIERE Unit Universit\u00e9 de Paris\u2010Cit\u00e9 Paris France"},{"name":"Radiology Department H\u00f4pital Necker\u2010Enfants Malades AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8421-9971","authenticated-orcid":false,"given":"O.","family":"Picone","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department H\u00f4pital Louis\u2010Mourier AP\u2010HP Colombes France"},{"name":"Inserm IAME\u2010U1137 Paris France"},{"name":"FHU PREMA Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Mandelbrot","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department H\u00f4pital Louis\u2010Mourier AP\u2010HP Colombes France"},{"name":"Inserm IAME\u2010U1137 Paris France"},{"name":"FHU PREMA Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Mahallati","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Calgary Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Briand","sequence":"additional","affiliation":[{"name":"Clinical Unit Research\/Clinic Investigation Center Paris Descartes University, H\u00f4pital Necker\u2010Enfants Malades AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Elie","sequence":"additional","affiliation":[{"name":"Clinical Unit Research\/Clinic Investigation Center Paris Descartes University, H\u00f4pital Necker\u2010Enfants Malades AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Siauve","sequence":"additional","affiliation":[{"name":"Radiology Department H\u00f4pital Louis\u2010Mourier AP\u2010HP Colombes France"},{"name":"INSERM\u2010U970, Paris Cardiovascular Research Center (PARCC), Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. J.","family":"Salomon","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department H\u00f4pital Necker\u2010Enfants Malades AP\u2010HP Paris France"},{"name":"EA FETUS 7328 and LUMIERE Unit Universit\u00e9 de Paris\u2010Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1986.tb07830.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90770-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13148"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910390503"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2712-y"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13121742"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12395"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24581"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017162385"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14917"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2016.11.009"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2017.11.002"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20855"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14057"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4019"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgyn.2006.09.001"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5315"},{"key":"e_1_2_7_19_1","author":"Comit\u00e9 National Technique de l'\u00c9chographie de D\u00e9pistage Pr\u00e9natal","year":"2005","journal-title":"Rapport du Comit\u00e9 National Technique de l'\u00c9chographie de D\u00e9pistage Pr\u00e9natal"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0730-725X(01)00421-0"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.07.008"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12805"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910370621"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.12.018"}],"container-title":["Ultrasound in Obstetrics & Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.27496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T08:22:33Z","timestamp":1712910153000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.27496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/uog.27496"],"URL":"https:\/\/doi.org\/10.1002\/uog.27496","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2023-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}