{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:37:05Z","timestamp":1791311825611,"version":"4.3.1"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100015471","name":"Mater Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015471","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the association between placental biomarkers (placental growth factor (PlGF) and soluble fms\u2010like tyrosine kinase\u20101 (sFlt\u20101)\/PlGF ratio) and fetoplacental Doppler indices (umbilical artery (UA) pulsatility index (PI) and uterine artery (UtA) PI) in various combinations for predicting preterm birth (PTB) in pregnancies complicated by fetal growth restriction (FGR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective observational cohort study, performed at Mater Mother's Hospital in Brisbane, Queensland, Australia, from May 2022 to June 2023, of pregnancies complicated by FGR and appropriate\u2010for\u2010gestational\u2010age (AGA) pregnancies. Maternal serum PlGF levels, sFlt\u20101\/PlGF ratio, UA\u2010PI and UtA\u2010PI were measured at 2\u20134\u2010weekly intervals from recruitment until delivery. Harrell's concordance statistic (Harrell's C) was used to evaluate multivariable Cox proportional hazards regression models featuring various combinations of placental biomarkers and fetoplacental Doppler indices to ascertain the best combination to predict PTB (&lt;\u200937\u2009weeks). Multivariable Cox regression models were used with biomarkers as time\u2010varying covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study cohort included 320 singleton pregnancies, comprising 179 (55.9%) affected by FGR, defined according to a Delphi consensus, and 141 (44.1%) with an AGA fetus. In the FGR cohort, both low PlGF levels and elevated sFlt\u20101\/PlGF ratio were associated with significantly shorter time to PTB. Low PlGF was a better predictor of PTB than was either sFlt\u20101\/PlGF ratio or a combination of PlGF and sFlt\u20101\/PlGF ratio (Harrell's C, 0.81, 0.78 and 0.79, respectively). Although both Doppler indices were significantly associated with time to PTB, in combination they were better predictors of PTB than was either UA\u2010PI\u2009&gt;\u200995\n                      <jats:sup>th<\/jats:sup>\n                      centile or UtA\u2010PI\u2009&gt;\u200995\n                      <jats:sup>th<\/jats:sup>\n                      centile alone (Harrell's C, 0.82, 0.75 and 0.76, respectively). Predictive utility for PTB was best when PlGF &lt;\u2009100\u2009ng\/L, UA\u2010PI\u2009&gt;\u200995\n                      <jats:sup>th<\/jats:sup>\n                      centile and UtA\u2010PI\u2009&gt;\u200995\n                      <jats:sup>th<\/jats:sup>\n                      centile were combined (Harrell's C, 0.88) (hazard ratio, 32.99; 95%\u2009CI, 10.74\u2013101.32).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Low maternal serum PlGF level (&lt;\u2009100\u2009ng\/L) and abnormal fetoplacental Doppler indices (UA\u2010PI\u2009&gt;\u200995\n                      <jats:sup>th<\/jats:sup>\n                      centile and UtA\u2010PI\u2009&gt;\u200995\n                      <jats:sup>th<\/jats:sup>\n                      centile) in combination have the greatest predictive utility for PTB in pregnancies complicated by FGR. Their assessment may help guide clinical management of these complex pregnancies. \u00a9 2023 The Authors.\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.27513","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T15:18:50Z","timestamp":1697037530000},"page":"635-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Placental growth factor and fetoplacental Doppler indices in combination predict preterm birth reliably in pregnancies complicated by fetal growth restriction"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8585-2357","authenticated-orcid":false,"given":"J.","family":"Hong","sequence":"first","affiliation":[{"name":"Mater Research Institute University of Queensland  South Brisbane Queensland Australia"},{"name":"Faculty of Medicine The University of Queensland  Herston Queensland Australia"},{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Crawford","sequence":"additional","affiliation":[{"name":"Mater Research Institute University of Queensland  South Brisbane Queensland Australia"},{"name":"Faculty of Medicine The University of Queensland  Herston Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Cavanagh","sequence":"additional","affiliation":[{"name":"Mater Research Institute University of Queensland  South Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0765-7780","authenticated-orcid":false,"given":"F.","family":"da Silva Costa","sequence":"additional","affiliation":[{"name":"School of Medicine and Dentistry, Griffith University and Maternal Fetal Medicine Unit Gold Coast University Hospital  Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0832-4811","authenticated-orcid":false,"given":"S.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Mater Research Institute University of Queensland  South Brisbane Queensland Australia"},{"name":"Faculty of Medicine The University of Queensland  Herston Queensland Australia"},{"name":"NHMRC Centre for Research Excellence in Stillbirth, Mater Research Institute University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"issue":"263","key":"e_1_2_9_3_1","article-title":"Approximately one\u2010third of medically indicated late preterm births are complicated by fetal growth restriction","volume":"204","author":"Carreno CA","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340802005126"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.111719"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13522"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22134"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.05.010"},{"key":"e_1_2_9_9_1","unstructured":"Royal College of Obstetricians & Gynaecologists (RCOG).Small\u2010for\u2010Gestational\u2010Age Fetus Investigation and Management (Green\u2010top Guideline No. 31). 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