{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:38:33Z","timestamp":1770957513865,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To confirm the identity and assess the prevalence and evolution of the fluid\u2010filled interhemispheric midline structure, thought to be the cavum veli interpositi (CVI), in fetuses at 11\u201314\u2009weeks' gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of first\u2010trimester ultrasound scans performed at a single center over 3\u2009months. Inclusion criteria were singleton pregnancies at 11\u201314\u2009weeks' gestation with known neonatal outcome. Five experts reviewed the images. Mixed\u2010effects logistic regression and generalized estimating equations (GEE) were conducted to analyze the associations between the presence of the structure and variables including ultrasound approach (transabdominal <jats:italic>vs<\/jats:italic> transvaginal), maternal body mass index (BMI), gestational age, fetal crown\u2013rump length (CRL) and biparietal diameter (BPD). Second\u2010trimester ultrasound scans of the fetal central nervous system at 18\u201324\u2009weeks' gestation were evaluated for the persistence of the CVI in  fetuses in which the structure was observed in the first trimester.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 223 cases reviewed, 104 were included, among which the CVI was observed in 25 (24%) cases. There was no statistically significant difference in CVI visualization between transabdominal and transvaginal ultrasound examinations. GEE showed significant associations between the presence of the fetal structure and CRL (odds ratio (OR) per 10\u2010unit increase, 1.32; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) and BPD (OR per 10\u2010unit increase, 1.88; <jats:italic>P\u2009=<\/jats:italic>\u20090.0011). Maternal BMI and gestational age showed no significant effect on the presence of the CVI. At second\u2010trimester follow\u2010up of the 25 fetuses in which the CVI was observed initially, 44% still showed a CVI, 32% exhibited a cavum vergae, 4% had both structures and 20% had neither.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on its anatomical location and, in some fetuses, its visualization as a distinct entity from the third ventricle, the identity of the interhemispheric midline structure in the suprathalamic region of the fetal brain between 11\u201314\u2009weeks' gestation was confirmed as the CVI. The  CVI and\/or cavum vergae persisted into the second trimester in 80% of fetuses identified initially as having a CVI. Its presence is not linked to pathology, offering reassurance to practitioners and parents. \u00a9 2023 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.27523","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T15:35:21Z","timestamp":1698680121000},"page":"502-506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["First\u2010trimester cavum veli interpositi: prevalence and natural history"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7207-0062","authenticated-orcid":false,"given":"E.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Florida  Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Pierre","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Florida  Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Acevedo","sequence":"additional","affiliation":[{"name":"College of Medicine University of Florida  Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2063-7765","authenticated-orcid":false,"given":"R.","family":"Egerman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Florida  Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5962-2854","authenticated-orcid":false,"given":"D.","family":"Rajderkar","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Florida  Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8427-7351","authenticated-orcid":false,"given":"R. S.","family":"Abu\u2010Rustum","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Florida  Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP2268"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2021.05.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.32.9.1623"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-011-1457-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2016.00011"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40556-015-0065-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.261055033"},{"key":"e_1_2_7_9_1","first-page":"1631","article-title":"Sonographic characteristics of the cavum velum interpositum","volume":"19","author":"Chen CY","year":"1998","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22176"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23616"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26106"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17246"},{"key":"e_1_2_7_14_1","first-page":"E1","article-title":"AIUM practice parameter for the performance of detailed diagnostic obstetric ultrasound examinations between 12\u2009 weeks 0\u2009 days and 13\u2009 weeks 6 \u2009days","volume":"40","year":"2021","journal-title":"J Ultrasound Med"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2019.09.016"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.27523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T12:22:08Z","timestamp":1712924528000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.27523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/uog.27523"],"URL":"https:\/\/doi.org\/10.1002\/uog.27523","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2023-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}