{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:29:05Z","timestamp":1786634945448,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the association between changes in cervical length (CL) after vaginal progesterone treatment and preterm delivery (PTD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a retrospective cohort study that included 197 singleton pregnancies without (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009178) and with (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919) a history of PTD which were found to have a short cervix (\u2264\u200925\u2009mm) between 18\u2009+\u20090 and 23\u2009+\u20096\u2009weeks' gestation with a follow\u2010up transvaginal CL measurement taken at least 1 week after vaginal progesterone treatment started. Receiver\u2010operating\u2010characteristics (ROC)\u2010curve analysis was performed and three CL shortening patterns were evaluated: (1) \u2265\u200910% reduction; (2) \u2265\u200920% reduction; and (3) \u2265\u20095\u2009mm reduction relative to the first CL measurement. The predictive performance of each CL reduction cut\u2010off and its association with PTD \u2264\u200934\u2009weeks and PTD &lt;\u200937\u2009weeks were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, the rate of PTD \u2264\u200934\u2009weeks was 16.8% (33\/197) and that of PTD &lt;\u200937\u2009weeks was 36.5% (72\/197). The area under the ROC curve of cervical shortening expressed in % for predicting PTD \u2264\u200934\u2009weeks and PTD &lt;\u200937\u2009weeks was 0.703 and 0.608, respectively. Cervical shortening was observed in 60\/197 (30.5%) patients, with 49\/60 (81.7%) women showing \u2265\u200910%  reduction, 32\/60 (53.3%) \u2265\u200920% reduction and 27\/60 (45.0%) \u2265\u20095\u2009mm reduction in CL. Sensitivity and specificity for PTD \u2264\u200934\u2009weeks were, respectively, 48.5% and 79.9% for \u2265\u200910% reduction; 36.4% and 87.8% for \u2265\u200920% reduction; and 27.3% and 89.0% for \u2265\u20095\u2009mm reduction in CL. For PTD &lt;\u200937\u2009weeks, sensitivity and specificity were, respectively, 36.1% and 81.6% for \u2265\u200910% reduction; 27.8% and 90.4% for \u2265\u200920% reduction; and 20.8% and 90.4% for \u2265\u20095\u2009mm reduction in CL. The highest positive likelihood ratios for PTD \u2264\u200934 and &lt;\u200937\u2009weeks were for \u2265\u200920% CL reduction (2.98 (95%\u2009CI, 1.62\u20135.49) and 2.89 (95%\u2009CI, 1.52\u20135.57), respectively). Despite significant differences in sensitivity among the different cut\u2010offs for cervical shortening, favoring the \u2265\u200910% reduction cut\u2010off, a reduction of \u2265\u200920% in CL showed the strongest association with PTD \u2264\u200934\u2009weeks (odds ratio (OR), 4.11 (95%\u2009CI, 1.75\u20139.62)) and &lt;\u200937\u2009weeks (OR,\u00a03.62 (95%\u2009CI, 1.65\u20137.96)), as compared with a less pronounced reduction in CL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In women with a short cervix treated with vaginal progesterone, a reduction in CL on a subsequent ultrasound scan can predict PTD \u2264\u200934 and &lt;\u200937\u2009weeks. A \u2265\u200920% reduction in CL had the highest positive likelihood ratio and strongest association with PTD \u2264\u200934 and &lt;\u200937\u2009weeks compared with \u2265\u200910% or \u2265\u20095\u2009mm reduction. \u00a9 2023 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.27527","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T07:28:46Z","timestamp":1698910126000},"page":"644-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Reduction in cervical length after vaginal progesterone in women with short cervix is significantly associated with preterm delivery at \u2264 34 weeks and &lt; 37 weeks of gestation"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0286-6678","authenticated-orcid":false,"given":"E.","family":"Hernandez\u2010Andrade","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical School University of Texas, Health Science Center at Houston (UTHealth)  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. S.","family":"Huntley","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical School University of Texas, Health Science Center at Houston (UTHealth)  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Sibai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical School University of Texas, Health Science Center at Houston (UTHealth)  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. C.","family":"Blackwell","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical School University of Texas, Health Science Center at Houston (UTHealth)  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. E.","family":"Soto\u2010Torres","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical School University of Texas, Health Science Center at Houston (UTHealth)  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.11.576"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.12.222"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.03.028"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2022.100658"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.06.020"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2020.101989"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.115119"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(04)16351\u20104"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17457"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001820"},{"key":"e_1_2_8_12_1","volume-title":"The Nine Criteria for Transvaginal Ultrasound Cervical Length Measurement","author":"Foundation PQ","year":"2020"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm\u20102012\u20100272"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469\u20100705.1997.09030188.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9017"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15953"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100040\u20101710008"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.13592"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.01.221"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.10.020"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7338"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469\u20100705.2002.00765.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1487939"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2021.100430"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13837"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.27527","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.27527","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.27527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:37:31Z","timestamp":1786631851000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.27527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,15]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/uog.27527"],"URL":"https:\/\/doi.org\/10.1002\/uog.27527","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,15]]},"assertion":[{"value":"2023-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}