{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:08:49Z","timestamp":1791295729135,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Around 80% of women with endometriosis have superficial endometriosis (SE) rather than ovarian or deep endometriosis (DE). However, to date, advances in non\u2010invasive, imaging\u2010based diagnosis have been limited to DE or ovarian disease. The objective of this study was to determine whether we can detect SE on transvaginal ultrasound scan (TVS) by assessing the peritoneum of the pouch of Douglas (POD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective diagnostic test study following a change in practice to include POD peritoneum assessment for SE during TVS at a tertiary London hospital. Eligible patients underwent TVS by a single clinician trained in endometriosis scanning and a subsequent surgical procedure (laparoscopy) between April 2018 and September 2021. Participants formed a consecutive series. The TVS findings were compared with those of laparoscopy as the gold standard. Comparison of TVS findings with intraoperative findings was performed by calculating the diagnostic test performance measures (sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and positive and negative likelihood ratios).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included a total of 100 patients. We found that 43\/100 (43.0%) patients had no endometriosis, 33\/100 (33.0%) had SE and 24\/100 (24.0%) had DE on laparoscopy. SE was correctly detected on TVS in 17\/33 patients, with a sensitivity of 51.5% (95% CI, 33.5\u201369.2%), specificity of 94.0% (95% CI, 85.4\u201398.4%), PPV of 81.0% (95% CI, 60.8\u201392.1%) and NPV of 79.7% (95% CI, 73.4\u201384.9%). DE was correctly diagnosed in 20\/24 cases, including all ovarian cases, with a sensitivity of 83.3% (95% CI, 62.3\u201395.3%), specificity of 97.4% (95% CI, 90.8\u201399.7%), PPV of 90.9% (95% CI, 71.6\u201397.5%) and NPV of 94.9% (95% CI, 88.3\u201397.8%). The detection of SE on TVS was most accurate in the POD (sensitivity, 50.0%; specificity, 96.4%; PPV, 76.9%; NPV, 88.9%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study shows that the detection of SE in the POD is possible using routine TVS. While negative TVS does not reliably confirm the absence of disease or replace diagnostic laparoscopy, positive TVS facilitates non\u2010invasive diagnosis for a much larger group of women than was previously possible. This should help to reduce the time from the onset of symptoms to diagnosis and enable initiation of medical treatment without the risk, cost and delay associated with a surgical diagnosis. \u00a9 2023 The Authors.\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.27529","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:52:06Z","timestamp":1699231926000},"page":"105-112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Diagnosis of superficial endometriosis on transvaginal ultrasound by visualization of peritoneum of pouch of Douglas"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2449-302X","authenticated-orcid":false,"given":"F.","family":"Bailey","sequence":"first","affiliation":[{"name":"Department of Women's Health Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gaughran","sequence":"additional","affiliation":[{"name":"Department of Women's Health Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Women's Health Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ovadia","sequence":"additional","affiliation":[{"name":"Department of Women's Health Guy's and St Thomas' NHS Foundation Trust  London UK"},{"name":"Faculty of Life Sciences &amp; Medicine at Guy's, School of Life Course Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. K.","family":"Holland","sequence":"additional","affiliation":[{"name":"Department of Women's Health Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8545(05)70302-8"},{"key":"e_1_2_8_3_1","first-page":"1","article-title":"ESHRE guideline: endometriosis","volume":"2","author":"Becker CM","year":"2022","journal-title":"Hum Reprod Open"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)53570-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2004.03.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew293"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoab029"},{"key":"e_1_2_8_8_1","first-page":"1","volume-title":"Endometriosis in the UK: time for change. 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