{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:29:11Z","timestamp":1786634951374,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"publisher","award":["1037116"],"award-info":[{"award-number":["1037116"]}],"id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>First, to evaluate the predictive performance for preterm growth\u2010related neonatal morbidity of a high soluble fms\u2010like tyrosine kinase\u20101 (sFlt\u20101)\/placental growth factor (PlGF) ratio or low PlGF at midgestation and, second, to compare the performance of a high sFlt\u20101\/PlGF ratio or low PlGF with that of the competing\u2010risks model for small\u2010for\u2010gestational age (SGA), utilizing a combination of maternal risk factors, sonographic estimated fetal weight and uterine artery pulsatility index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a prospective observational study in women attending for a routine hospital visit at 19\u201324\u2009weeks' gestation in two maternity hospitals in England. The visit included recording of maternal demographic characteristics and medical history, carrying out an ultrasound scan and measuring serum PlGF and sFlt\u20101. The primary outcome was delivery &lt;\u200932 and &lt;\u200937\u2009weeks' gestation of a SGA neonate with birth weight &lt;\u200910\n                      <jats:sup>th<\/jats:sup>\n                      or &lt;\u20093\n                      <jats:sup>rd<\/jats:sup>\n                      percentile, combined with neonatal unit (NNU) admission for \u2265\u200948\u2009h or a composite of major neonatal morbidity. The detection rates in screening by PlGF &lt;\u200910\n                      <jats:sup>th<\/jats:sup>\n                      percentile, sFlt\u20101\/PlGF ratio &gt;\u200990\n                      <jats:sup>th<\/jats:sup>\n                      percentile and the competing\u2010risks model for SGA were estimated and then compared using McNemar's test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the study population of 40\u2009241 women, prediction of preterm growth\u2010related neonatal morbidity provided by the competing\u2010risks model for SGA was superior to that of screening by low PlGF concentration or high sFlt\u20101\/PlGF ratio. For example, at a screen\u2010positive rate of 10.0%, as defined by the sFlt\u20101\/PlGF ratio &gt;\u200990\n                      <jats:sup>th<\/jats:sup>\n                      percentile, the competing\u2010risks model predicted 70.1% (95%\u00a0CI, 61.0\u201379.2%) of SGA &lt;\u200910\n                      <jats:sup>th<\/jats:sup>\n                      percentile and 76.9% (95%\u00a0CI, 67.6\u201386.3%) of SGA &lt;\u20093\n                      <jats:sup>rd<\/jats:sup>\n                      percentile with NNU admission for \u2265\u200948\u2009h delivered &lt;\u200932\u2009weeks' gestation. The respective values for SGA with major neonatal morbidity were 73.8% (95%\u00a0CI, 64.4\u201383.2%) and 77.9% (95%\u00a0CI, 68.0\u201387.8%). These were significantly higher than the respective values of 35.1% (95%\u00a0CI, 25.6\u201344.6%), 35.9% (95%\u00a0CI, 25.3\u201346.5%), 38.1% (95%\u00a0CI, 27.7\u201348.5%) and 39.7% (95%\u00a0CI, 28.1\u201351.3%) achieved by the application of the sFlt\u20101\/PlGF ratio &gt;\u200990\n                      <jats:sup>th<\/jats:sup>\n                      percentile (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>At midgestation, the prediction of growth\u2010related neonatal morbidity by the competing\u2010risks model for SGA is superior to that of a high sFlt\u20101\/PlGF ratio or low PlGF. \u00a9 2023 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.27559","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T17:39:51Z","timestamp":1701970791000},"page":"613-618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of competing\u2010risks model with angiogenic factors in midgestation screening for preterm growth\u2010related neonatal morbidity"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7969-1435","authenticated-orcid":false,"given":"I.","family":"Papastefanou","sequence":"first","affiliation":[{"name":"Department of Women and Children's Health, School of Life Course and Population Sciences, Faculty of Life Sciences &amp; Medicine King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Menenez","sequence":"additional","affiliation":[{"name":"Fetal Medicine Research Institute King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Szczepkowska","sequence":"additional","affiliation":[{"name":"Fetal Medicine Research Institute King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Gungil","sequence":"additional","affiliation":[{"name":"Fetal Medicine Research Institute King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5856-6072","authenticated-orcid":false,"given":"A.","family":"Syngelaki","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health, School of Life Course and Population Sciences, Faculty of Life Sciences &amp; Medicine King's College London  London UK"},{"name":"Fetal Medicine Research Institute King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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