{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:56:25Z","timestamp":1774659385332,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet & Gyne"],"published-print":{"date-parts":[[2024,7]]},"abstract":"ABSTRACT<\/jats:title>Objective<\/jats:title>Image quality of fetal echocardiography (FE) has improved in the recent era, but few recent studies have reported the accuracy of FE, specifically in single ventricle (SV) congenital heart disease (CHD). This study aimed to assess the ability of FE to correctly predict SV\u2010CHD postnatal anatomy and physiology in a contemporary cohort.<\/jats:p><\/jats:sec>Methods<\/jats:title>The contemporary clinical reports of patients with SV<\/jats:styled-content>\u2010CHD<\/jats:styled-content>, in which FE<\/jats:styled-content> was performed between July 2017 and July 2021, were compared with postnatal echocardiograms from a formal quality assurance program. SV<\/jats:styled-content> fetuses were grouped by anatomical subtype. Diagnostic errors were designated as major if the error would have caused significant alteration in parental counseling or postnatal management. The remaining errors were classified as minor. Physiological discrepancies, including prostaglandin\u2010E (PGE<\/jats:styled-content>) dependency, atrioventricular valve regurgitation (AVVR<\/jats:styled-content>), pulmonary venous obstruction and restrictive atrial septum (RAS<\/jats:styled-content>), were assessed by chart review of the postnatal course.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 119 subjects were analyzed. SV<\/jats:styled-content> subtypes in the cohort included hypoplastic left heart syndrome (HLHS<\/jats:styled-content>) (n<\/jats:italic>\u2009=\u200968), tricuspid atresia (n<\/jats:italic>\u2009=\u200916), double\u2010inlet left ventricle (n<\/jats:italic>\u2009=\u200912), unbalanced atrioventricular canal (UAVC<\/jats:styled-content>) (n<\/jats:italic>\u2009=\u200911), heterotaxy (n<\/jats:italic>\u2009=\u20099) and other (n<\/jats:italic>\u2009=\u20093). The rate of major anatomical and physiological errors was low (n<\/jats:italic>\u2009=\u20096 (5.0%)). A higher proportion of minor errors was noted in HLHS<\/jats:styled-content> and tricuspid atresia, but the differences were not statistically significant. Physiological discrepancies were uncommon, with three major discrepancies, including underestimation of the degree of venous obstruction in one non\u2010HLHS<\/jats:styled-content> fetus with total anomalous pulmonary venous return, overestimation of RAS<\/jats:styled-content> in one HLHS<\/jats:styled-content> fetus and incorrect prediction of PGE<\/jats:styled-content> dependency in one case false\u2010negative for pulmonary blood flow. No discrepancy in degree of AVVR<\/jats:styled-content> or RAS<\/jats:styled-content> affected postnatal care. Minor physiological discrepancies included two false\u2010positive predictions of PGE<\/jats:styled-content> dependency with one false\u2010positive for ductal\u2010dependent systemic flow and one false\u2010positive for pulmonary blood flow.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In this contemporary review of FE<\/jats:styled-content> at our center, there was high accuracy in describing anatomical and physiological findings in SV<\/jats:styled-content>\u2010CHD<\/jats:styled-content>. Major physiological discrepancies were uncommon but included important cases of false\u2010negative prediction of PGE<\/jats:styled-content> dependency and underestimation of obstruction of total anomalous pulmonary venous return. These data can inform more accurate counseling of families with SV<\/jats:styled-content>\u2010CHD<\/jats:styled-content> fetuses and guide diagnostic improvement efforts. \u00a9 2024 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.27575","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T10:33:35Z","timestamp":1704882815000},"page":"50-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anatomical and physiological diagnostic discrepancies in fetuses with single\u2010ventricle congenital heart disease in a contemporary cohort"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7366-3620","authenticated-orcid":false,"given":"T.","family":"Patel","sequence":"first","affiliation":[{"name":"Emory University School of Medicine Atlanta GA USA"},{"name":"Children's Healthcare of Atlanta Atlanta GA USA"},{"name":"Nationwide Children's Hospital Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kreeger","sequence":"additional","affiliation":[{"name":"Children's Healthcare of Atlanta Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Sachdeva","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine Atlanta GA USA"},{"name":"Children's Healthcare of Atlanta Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Border","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine Atlanta GA USA"},{"name":"Children's Healthcare of Atlanta Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Michelfelder","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine Atlanta GA USA"},{"name":"Children's Healthcare of Atlanta Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2020.06.017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)04069-X"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.04.032"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2022.02.015"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7499"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1732457"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6355"},{"key":"e_1_2_8_9_1","unstructured":"ACPC Quality Network.Diagnostic Accuracy of Fetal 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