{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:50:16Z","timestamp":1789696216404,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T00:00:00Z","timestamp":1717286400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100031077","name":"Elsass Fonden","doi-asserted-by":"publisher","award":["20\u20103\u20100573"],"award-info":[{"award-number":["20\u20103\u20100573"]}],"id":[{"id":"10.13039\/100031077","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze perinatal risks associated with three distinct scenarios of fetal growth trajectory in the latter half of pregnancy compared with a reference group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cohort study included women with a singleton pregnancy that delivered between 32\u2009+\u20090 and 41\u2009+\u20096\u2009weeks' gestation and had two or more ultrasound scans, at least 4\u2009weeks apart, from 18\u2009+\u20090\u2009weeks. We evaluated three different scenarios of fetal growth against a reference group, which comprised appropriate\u2010for\u2010gestational\u2010age fetuses with appropriate forward\u2010growth trajectory. The comparator growth trajectories were categorized as: Group 1, small\u2010for\u2010gestational\u2010age (SGA) fetuses (estimated fetal weight (EFW) or abdominal circumference (AC) persistently &lt;\u200910<jats:sup>th<\/jats:sup> centile) with appropriate forward growth; Group 2, fetuses with decreased growth trajectory (decrease of \u2265\u200950 centiles) and EFW or AC \u2265\u200910<jats:sup>th<\/jats:sup> centile (i.e. non\u2010SGA) at their final ultrasound scan; and Group 3, fetuses with decreased growth trajectory and EFW or AC &lt;\u200910<jats:sup>th<\/jats:sup> centile (i.e. SGA) at their final scan. The primary outcome was overall perinatal mortality (stillbirth or neonatal death). Secondary outcomes included stillbirth, delivery of a SGA infant, preterm birth, emergency Cesarean section for non\u2010reassuring fetal status and composite severe neonatal morbidity. Associations were analyzed using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final study cohort comprised 5319 pregnancies. Compared to the reference group, the adjusted odds of perinatal mortality were increased significantly in Group 2 (adjusted odds ratio (aOR), 4.00 (95%\u2009CI, 1.36\u201311.22)) and Group 3 (aOR, 7.71 (95%\u2009CI, 2.39\u201324.91)). Only Group 3 had increased odds of stillbirth (aOR, 5.69 (95%\u2009CI, 1.55\u201320.93)). In contrast, infants in Group 1 did not have significantly increased odds of demise. The odds of a SGA infant at birth were increased in all three groups compared with the reference group, but was highest in Group 1 (aOR, 111.86 (95%\u2009CI, 62.58\u2013199.95)) and Group 3 (aOR, 40.63 (95%\u2009CI, 29.01\u201356.92)). In both groups, more than 80% of infants were born SGA and nearly half had a birth weight &lt;\u20093<jats:sup>rd<\/jats:sup> centile. Likewise, the odds of preterm birth were increased in all three groups  compared with the reference group, being  highest in Group 3, with an aOR of 4.27 (95%\u2009CI, 3.23\u20135.64). Lastly, the odds of composite severe neonatal morbidity were increased in Groups 1 and 3, whereas the odds of emergency Cesarean section for non\u2010reassuring fetal status were increased only in Group 3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Assessing the fetal growth trajectory in the latter half of pregnancy can help identify infants at increased risk of perinatal mortality and birth weight &lt;\u20093<jats:sup>rd<\/jats:sup> centile for gestation. \u00a9 2024 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.27610","type":"journal-article","created":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T06:49:45Z","timestamp":1707547785000},"page":"764-771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Assessment of fetal growth trajectory identifies infants at high risk of perinatal mortality"],"prefix":"10.1002","volume":"63","author":[{"given":"M. L.","family":"Larsen","sequence":"first","affiliation":[{"name":"Center for Cerebral Palsy, Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital\u00a0\u2010\u00a0Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Obstetrics and Gynecology Copenhagen University Hospital\u00a0\u2013\u00a0Amager\u2010Hvidovre  Hvidovre Denmark"},{"name":"Mater Research Institute University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Krebs","sequence":"additional","affiliation":[{"name":"Mater Research Institute University of Queensland  Brisbane Queensland Australia"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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