{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:26:13Z","timestamp":1785839173009,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2024,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n To investigate whether angiogenic markers of placental function are associated with maternal cardiac function and hemodynamic responses at 19\u201323\u2009weeks' gestation, controlling for\u2009maternal risk factors and pregnancy complications.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This was a prospective study of women with singleton pregnancy attending King's College Hospital, London, UK, for a routine hospital visit at 19\u201323\u2009weeks' gestation. We recorded maternal characteristics and measured mean arterial pressure (MAP), maternal heart rate, serum placental growth factor (PlGF) and soluble fms\u2010like tyrosine kinase\u20101 (sFlt\u20101). We also performed maternal echocardiography to assess cardiac output and peripheral vascular resistance as well as indices of diastolic and systolic function.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Our cohort included 4006 women.\u2009Lower PlGF values were significantly associated with higher MAP (\n P<\/jats:italic>\n \u2009<\u20090.0001), lower maternal heart rate (\n P<\/jats:italic>\n \u2009<\u20090.0001), lower mitral valve s\u2032 mean velocity (\n P\u2009=<\/jats:italic>\n \u20090.027) and higher left atrial area (\n P\u2009=<\/jats:italic>\n \u20090.022) after adjustment for\u2009maternal characteristics and pregnancy complications. sFlt\u20101 was associated positively with relative wall thickness (\n P\u2009=<\/jats:italic>\n \u20090.012), whereas sFlt\u20101\/PlGF ratio was associated negatively with mitral valve A (\n P\u2009=<\/jats:italic>\n \u20090.006) and positively with left atrial area (\n P\u2009=<\/jats:italic>\n \u20090.015) and MAP (\n P\u2009=<\/jats:italic>\n \u20090.004). The magnitude of these associations was similar in the subgroup of women without any risk factors based on their obstetric and medical history.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n A continuous association of moderate strength between angiogenic factors and subclinical maternal cardiac function alterations is present in midgestation, independently of pre\u2010existing maternal risk factors and pregnancy complications. Impaired placental function appears to be related to mild systolic and diastolic dysfunction and cardiac remodeling. \u00a9 2024 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/uog.27616","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T13:58:02Z","timestamp":1707919082000},"page":"180-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Maternal cardiovascular function in midgestation is related to placental angiogenesis"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7969-1435","authenticated-orcid":false,"given":"I.","family":"Papastefanou","sequence":"first","affiliation":[{"name":"Department of Women and Children's Health, School of Life Course and Population Sciences, Faculty of Life Sciences & Medicine King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Szczepkowska","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine, Fetal Medicine Research Institute King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tezhaeva","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine, Fetal Medicine Research Institute King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"De Pauli","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine, Fetal Medicine Research Institute King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Charakida","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. H.","family":"Nicolaides","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health, School of Life Course and Population Sciences, Faculty of Life Sciences & Medicine King's College London London UK"},{"name":"Harris Birthright Research Centre for Fetal Medicine, Fetal Medicine Research Institute King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euje.2006.12.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06667"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11191"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.034"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.11.016"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.02.016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.01.235"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23523"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23730"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10173786"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.27559"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.27533"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.01.011"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.09.017"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335366"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1975.tb00710.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1994.04010034.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2019.09.005"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003018"},{"key":"e_1_2_8_22_1","volume-title":"Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications: Report of a WHO Consultation. 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