{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:57:06Z","timestamp":1786978626877,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>An increased nuchal translucency (NT) thickness of \u2265\u20093.5\u2009mm is a well\u2010established marker for congenital anomalies and adverse pregnancy outcome between 11 and 14\u2009weeks' gestation, but little is known about its performance as a screening tool before 11\u2009weeks. We aimed to investigate, in a prospective setting, whether fetuses with increased NT before 11\u2009weeks are at risk for adverse pregnancy outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective cohort study including pregnant women with a viable fetus with NT \u2265\u20092.5\u2009mm and a crown\u2013rump length (CRL) &lt;\u200945\u2009mm. All included women were referred to our fetal medicine unit (FMU) and scheduled for a follow\u2010up scan where the NT was remeasured after 1\u2009week when the CRL was &gt;\u200945\u2009mm. Two groups were evaluated: cases with a normalized NT (&lt;\u20093.5\u2009mm) and cases with persistently increased NT (\u2265\u20093.5\u2009mm). The cases were monitored until 4\u2009weeks after delivery. The main outcome was a composite adverse outcome of aneuploidy, other genetic disorders, structural anomalies and pregnancy loss. We performed subgroup analyses of NT thickness at inclusion and normalized or persistently increased NT at follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 109 cases, of which 39 (35.8%) had an adverse pregnancy outcome. Of these, 64.1% (25\/39) were aneuploid, corresponding to 22.9% (25\/109) of the total study population. In the subgroups of NT thickness at inclusion of 2.5\u20133.4\u2009mm, 3.5\u20134.4\u2009mm and \u2265\u20094.5\u2009mm, an adverse outcome was reported in 22.0% (9\/41), 40.0% (18\/45) and 52.2% (12\/23), respectively. In fetuses with a normalized NT and without ultrasound abnormalities at the follow\u2010up scan, the incidence of adverse outcome was 8.5% (5\/59), of which 5.1% (3\/59) cases were aneuploid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Fetuses with an early increased NT thickness are at considerable risk of an adverse pregnancy outcome, even if the NT normalizes after 11\u2009weeks. Not all congenital anomalies can be diagnosed with routine first\u2010trimester screening, such as non\u2010invasive prenatal testing and\/or a first\u2010trimester anomaly scan. Therefore, expectant parents should always be referred to a FMU for detailed ultrasonography. Invasive prenatal testing should be offered if an increased NT of \u2265\u20092.5\u2009mm is observed before 11\u2009weeks' gestation. \u00a9 2024 The Authors.\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.27623","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T07:49:25Z","timestamp":1709020165000},"page":"164-172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Adverse pregnancy outcome in fetuses with early increased nuchal translucency: prospective cohort study"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2200-9607","authenticated-orcid":false,"given":"B. B.","family":"Bet","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam UMC location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Reproduction and Development  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8385-2150","authenticated-orcid":false,"given":"M. A.","family":"Lugthart","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam UMC location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Reproduction and Development  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. H.","family":"Linskens","sequence":"additional","affiliation":[{"name":"Amsterdam Reproduction and Development  Amsterdam The Netherlands"},{"name":"Department of Obstetrics and Gynecology Amsterdam UMC location Vrije Universiteit  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"van Maarle","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Amsterdam UMC location University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam UMC location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Reproduction and Development  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Pajkrt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam UMC location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Reproduction and Development  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den224"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.304.6831.867"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11280-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.05010015.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000053941"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2396"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.093"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199912)19:12<1104::AID-PD707>3.0.CO;2-2"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5299"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1975.tb00710.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6054"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00310-N"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13203"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4799"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5847"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14091"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26106"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5590"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20778"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.10.005"},{"key":"e_1_2_8_22_1","unstructured":"EUROCAT.Prevalence charts and tables\u00a0\u2013\u00a0Prevalence per 10 000 births (2005 to 2021): European Platform on Rare Disease Registration.2023https:\/\/eu\u2010rd\u2010platform.jrc.ec.europa.eu\/eurocat\/eurocat\u2010data\/prevalence_en"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2023.2193285"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31940-8"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23746"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6393"}],"container-title":["Ultrasound in Obstetrics &amp; 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