{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:36:59Z","timestamp":1787168219437,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Epidemiological studies suggest that, following\n                      <jats:italic>in\u2010utero<\/jats:italic>\n                      exposure to hypertensive disorder of pregnancy (HDP), children may be at increased long\u2010term cardiovascular risk, but data in early childhood are lacking. We aimed to investigate the independent influence of HDP on infant cardiac structure and function, after accounting for differences in childhood risk\u2010factor profile.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a longitudinal study of 71 children born of a pregnancy complicated by HDP (gestational hypertension or pre\u2010eclampsia) and 304 children born of a normotensive pregnancy. Detailed cardiovascular assessment was performed at mid gestation and at a median of 2.3 (interquartile range, 2.1\u20132.4)\u2009years postnatally. Linear mixed\u2010effects modeling was used to determine the independent influence of HDP on infant cardiac function and structure after accounting for differences in childhood risk\u2010factor profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no differences in demographic characteristics between children whose mother developed HDP and those born of a normotensive pregnancy, but delivery was earlier and birth weight was lower in the HDP group. In fetal life, there were no significant differences in cardiac function or structure between the HDP and non\u2010HDP groups. In early childhood, in the HDP group compared with the non\u2010HDP group, there was greater relative wall thickness (mean\u2009\u00b1\u2009SD, 0.7\u2009\u00b1\u20090.3\n                      <jats:italic>vs<\/jats:italic>\n                      0.6\u2009\u00b1\u20090.3;\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.047) and increased left ventricular mass (indexed to body surface area) (mean\u2009\u00b1\u2009SD, 80.9\u2009\u00b1\u200920.4\u2009g\/m\n                      <jats:sup>2<\/jats:sup>\n                      <jats:italic>vs<\/jats:italic>\n                      75.7\u2009\u00b1\u200916.5\u2009g\/m\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.024); however, these differences did not persist on multivariable analysis. Longitudinal analysis revealed that there was no difference in the change in cardiac functional indices from fetal life to early childhood between the HDP and non\u2010HDP groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is no evidence that HDP has an adverse effect on offspring cardiovascular health in fetal life or in early childhood. \u00a9 2024 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.27627","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T13:33:41Z","timestamp":1709559221000},"page":"44-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of hypertensive disorders of pregnancy on offspring cardiovascular function: from fetal life to early childhood"],"prefix":"10.1002","volume":"64","author":[{"given":"S.","family":"Dimopoulou","sequence":"first","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine, Fetal Medicine Research Institute King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Neculcea","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine, Fetal Medicine Research Institute King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7969-1435","authenticated-orcid":false,"given":"I.","family":"Papastefanou","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Galan","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine, Fetal Medicine Research Institute King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Androulaki","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine, Fetal Medicine Research Institute King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. H.","family":"Nicolaides","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine, Fetal Medicine Research Institute King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Charakida","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine, Fetal Medicine Research Institute King's College Hospital  London UK"},{"name":"School of Biomedical Engineering and Imaging Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2109523"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.07.025"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23521"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003805"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08414"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-021-01132-x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003906"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2021.01.008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S316351"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2011.04.006"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10143154"},{"key":"e_1_2_8_13_1","article-title":"202: gestational hypertension and preeclampsia","volume":"133","author":"ACOG practice bulletin no","year":"2019","journal-title":"Obstet Gynecol"},{"key":"e_1_2_8_14_1","unstructured":"World Health Organization.Child growth standards.https:\/\/www.who.int\/tools\/child\u2010growth\u2010standards\/standards"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2019.09.005"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2022.12.016"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110627"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.07.059"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2018.06.013"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.42064"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174420000896"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13122007"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1994.tb01085.x"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.27627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T14:20:48Z","timestamp":1735568448000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.27627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,10]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/uog.27627"],"URL":"https:\/\/doi.org\/10.1002\/uog.27627","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,10]]},"assertion":[{"value":"2024-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}