{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:30:37Z","timestamp":1789835437585,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T00:00:00Z","timestamp":1719014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T00:00:00Z","timestamp":1719014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the diagnostic performance of transvaginal sonography (TVS) for the preoperative evaluation of lymph\u2010node metastasis in gynecological cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a systematic review and meta\u2010analysis of studies published between January 1990 and May 2023 evaluating the role of ultrasound in detecting pelvic lymph\u2010node metastasis (index test) in gynecological cancer, using histopathological analysis as the reference standard. The quality of included studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies\u20102 tool. Pooled sensitivity, specificity and diagnostic odds ratio were estimated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The literature search identified 2638 citations. Eight studies reporting on a total of 967 women were included. The mean prevalence of pelvic lymph\u2010node metastasis was 24.2% (range, 14.0\u201365.6%). The risk of bias was low for most domains assessed. Pooled sensitivity, specificity and diagnostic odds ratio of TVS were 41% (95%\u2009CI, 26\u201358%), 98% (95%\u2009CI, 93\u201399%) and 32 (95%\u2009CI, 14\u201372), respectively. High heterogeneity was found between studies for both sensitivity and specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      TVS showed a high pooled specificity for the detection of pelvic lymph\u2010node metastasis in gynecological cancer, but pooled sensitivity was low. \u00a9 2024 The Authors.\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.27633","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T14:03:07Z","timestamp":1709820187000},"page":"155-163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Role of ultrasound in detection of lymph\u2010node metastasis in gynecological cancer: systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"64","author":[{"given":"A. C.","family":"Borges","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Hospital de Braga  Braga Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Veloso","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Centro Materno\u2010Infantil do Norte Centro Hospitalar e Universit\u00e1rio de Santo Ant\u00f3nio  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Galindo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hospital Barros Luco Trudeau  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dan\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hospital Universitari Doctor Josep Trueta  Girona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Chacon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine Universidad de Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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