{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:43:55Z","timestamp":1783943035321,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the capacity of fetal pancreatic size, before standard blood glucose testing for screening and diagnosis, to predict maternal gestational diabetes mellitus (GDM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study of low\u2010risk pregnant women recruited during routine second\u2010trimester fetal anatomical screening at 20\u201325\u2009weeks' gestation at two ultrasound units in Israel between 2017 and 2020. The predictive performance of fetal pancreatic circumference \u2265\u200980<jats:sup>th<\/jats:sup> and \u2265\u200990<jats:sup>th<\/jats:sup> centiles and glucose challenge test (GCT) was examined for the outcome of GDM. The independent\u2010samples <jats:italic>t<\/jats:italic>\u2010test was used to compare mean pancreatic circumference centile between pregnancies with GDM and those without GDM. Diagnostic performance was evaluated with 2\u2009\u00d7\u20092 contingency tables and receiver\u2010operating\u2010characteristics (ROC) curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 195 women were selected for statistical analysis. Twenty\u2010four (12.3%) women were diagnosed subsequently with GDM. The mean\u2009\u00b1\u2009SD fetal  pancreatic circumference centile was significantly higher in the GDM group compared with the non\u2010GDM group (82.4\u2009\u00b1\u200914.6 <jats:italic>vs<\/jats:italic> 62.8\u2009\u00b1\u200927.6; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The pancreatic circumference centile was correlated positively with the estimated fetal weight centile (Pearson's coefficient, 0.243; <jats:italic>P<\/jats:italic>\u2009=\u20090.001). The 80<jats:sup>th<\/jats:sup> centile cut\u2010off for pancreatic circumference had the highest sensitivity (70.8%) and positive predictive value (23.3%) for future maternal GDM, with the best trade\u2010off between sensitivity and specificity achieved at the 75<jats:sup>th<\/jats:sup> centile cut\u2010off (sensitivity, 79%; specificity, 60%). The GCT had better specificity (90.2%) and negative predictive value (97.9%) compared with both cut\u2010offs in pancreatic circumference. The area under the ROC curve was higher for pancreatic circumference compared with GCT (0.71 <jats:italic>vs<\/jats:italic> 0.64) and only the former was statistically significant (<jats:italic>P<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fetal pancreatic circumference has a higher positive predictive capacity compared with GCT. Measuring pancreatic circumference can identify pregnancies at high risk for maternal GDM, thereby promoting earlier diagnosis and treatment, decreasing the time period during which the fetus is exposed to high maternal glucose levels and improving infant outcome. \u00a9 2024 The Author(s). <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.27719","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T14:28:22Z","timestamp":1722522502000},"page":"348-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Predictive capacity of fetal pancreatic circumference for gestational diabetes mellitus"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5266-7769","authenticated-orcid":false,"given":"Y.","family":"Gilboa","sequence":"first","affiliation":[{"name":"Ultrasound Unit, The Helen Schneider Women's Hospital Rabin Medical Center  Petach Tikva Israel"},{"name":"Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5953-1496","authenticated-orcid":false,"given":"Y.","family":"Geron","sequence":"additional","affiliation":[{"name":"Ultrasound Unit, The Helen Schneider Women's Hospital Rabin Medical Center  Petach Tikva Israel"},{"name":"Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8023-0679","authenticated-orcid":false,"given":"S.","family":"Perlman","sequence":"additional","affiliation":[{"name":"Ultrasound Unit, The Helen Schneider Women's Hospital Rabin Medical Center  Petach Tikva Israel"},{"name":"Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5588-1410","authenticated-orcid":false,"given":"L.","family":"Drukker","sequence":"additional","affiliation":[{"name":"Ultrasound Unit, The Helen Schneider Women's Hospital Rabin Medical Center  Petach Tikva Israel"},{"name":"Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ofir","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Prenatal Diagnostic Unit, Department of Obstetrics and Gynecology The Chaim Sheba Medical Center at Tel\u2010Hashomer  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ellert","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4545-7234","authenticated-orcid":false,"given":"R.","family":"Bardin","sequence":"additional","affiliation":[{"name":"Ultrasound Unit, The Helen Schneider Women's Hospital Rabin Medical Center  Petach Tikva Israel"},{"name":"Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Achiron","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Prenatal Diagnostic Unit, Department of Obstetrics and Gynecology The Chaim Sheba Medical Center at Tel\u2010Hashomer  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3265-408X","authenticated-orcid":false,"given":"Z.","family":"Kivilevitch","sequence":"additional","affiliation":[{"name":"Maccabi Health Services, Ultrasound Unit The Negev Medical Center  Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"281","article-title":"Principles and practice of screening for disease","volume":"65","author":"Wilson JM","year":"1968","journal-title":"Bol Oficina Sanit Panam"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.0160330"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1112"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14233"},{"key":"e_1_2_7_6_1","first-page":"382","article-title":"Sonographic measurement of the fetal pancreas in women with gestational diabetes","volume":"18","author":"Gilboa Y","year":"2021","journal-title":"Arch Med Sci"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-3985-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002501"},{"key":"e_1_2_7_9_1","volume-title":"Diabetes in Pregnancy: Management of Diabetes and its Complications from Preconception to the Postnatal Period","author":"National Collaborating Centre for Women's and Children's Health (UK)","year":"2015"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-S002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.24897"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90298-4"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5939"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(15)30033-3"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-022-06860-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6743a2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-019-01404-8"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2010.02995.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.03254.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-159-2-201307160-00657"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(82)90349-0"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.27719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T13:25:45Z","timestamp":1743773145000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.27719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/uog.27719"],"URL":"https:\/\/doi.org\/10.1002\/uog.27719","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2024-02-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}