{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:16:04Z","timestamp":1787494564675,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,6,12]],"date-time":"2006-06-12T00:00:00Z","timestamp":1150070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the degree of ductus venosus (DV) shunting in fetuses with intrauterine growth restriction (IUGR) and the effect of various degrees of umbilical circulatory compromise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a cross\u2010sectional observational study. Sixty\u2010four fetuses with IUGR (estimated weight \u2264 2.5\n                      <jats:sup>\n                        <jats:italic>th<\/jats:italic>\n                      <\/jats:sup>\n                      percentile) underwent ultrasound examination. The diameter, velocity, and blood flow were determined in the DV and intra\u2010abdominal umbilical vein (UV), and the fraction of shunting and DV : UV diameter ratios were calculated. Placental compromise was classified according to either normal umbilical artery (UA) pulsatility index (PI), UA\u2010PI &gt; 97.5\n                      <jats:sup>\n                        <jats:italic>th<\/jats:italic>\n                      <\/jats:sup>\n                      percentile, or absent or reversed end\u2010diastolic flow velocity (A\/REDV). Regression analysis was used to construct mean values, and SD scores were used to determine differences compared with a reference population (\n                      <jats:italic>n<\/jats:italic>\n                      = 212) after ln\u2010 or power\u2010transformation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the 64 growth\u2010restricted fetuses, the average DV shunting was 39% compared with 25% in the reference group (overall\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001). The corresponding values in the subgroups with normal UA\u2010PI, UA\u2010PI &gt; 97.5\n                      <jats:sup>\n                        <jats:italic>th<\/jats:italic>\n                      <\/jats:sup>\n                      percentile, and A\/REDV were 31%, 35%, and 57%, respectively. Fetuses with IUGR and normal UA\u2010PI (SD score: mean, 0.48; 95% CI, 0.04\u20130.92) did not shunt significantly more than did the reference fetuses (SD score: mean, 0.0; 95% CI, \u2212 0.15 to 0.15), but those with UA\u2010PI &gt; 97.5\n                      <jats:sup>\n                        <jats:italic>th<\/jats:italic>\n                      <\/jats:sup>\n                      percentile (SD score: mean, 0.85; 95% CI, 0.41\u20131.29), and particularly those with A\/REDV (SD score: mean, 1.56; 95% CI, 1.0\u20132.12) did shunt significantly more. With more DV shunting, these fetuses distributed correspondingly less umbilical blood to the liver, one of the mechanisms being a lower perfusion pressure as reflected in the lower DV blood velocity (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DV shunting is higher and the umbilical blood flow to the liver is less in fetuses with IUGR, particularly in those with the most severe umbilical hemodynamic compromise. Copyright \u00a9 2006 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.2784","type":"journal-article","created":{"date-parts":[[2006,6,12]],"date-time":"2006-06-12T09:04:57Z","timestamp":1150103097000},"page":"143-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":139,"title":["Ductus venosus shunting in growth\u2010restricted fetuses and the effect of umbilical circulatory compromise"],"prefix":"10.1002","volume":"28","author":[{"given":"T.","family":"Kiserud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ebbing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,6,12]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92720-M"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-5629(92)90005-U"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.1.129"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.11.028"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00591.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00590.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2002.00627.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(70)90341-8"},{"key":"e_1_2_5_10_2","first-page":"H724","article-title":"Preferential streaming of ductus venosus blood to the brain and heart in fetal lambs","volume":"237","author":"Edelstone DI","year":"1979","journal-title":"Am J Physiol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(83)90684-1"},{"key":"e_1_2_5_12_2","first-page":"189","article-title":"Cardiovascular responses to acute, severe haemorrhage in fetal sheep","volume":"15","author":"Meyers RL","year":"1991","journal-title":"J Dev Physiol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1992.02060389.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70504-7"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.3.H1256"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70528-9"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.11.018"},{"key":"e_1_2_5_18_2","article-title":"Fetal cardiac output, distribution to the placenta and impact of placental compromise","author":"Kiserud T","journal-title":"Ultrasound Obstet Gynecol"},{"key":"e_1_2_5_19_2","first-page":"3","article-title":"Intrauterine growth pattern by the tendency to repeat small\u2010for\u2010gestational\u2010age births in successive pregnancies","volume":"76","author":"Bakketeig LS","year":"1997","journal-title":"Acta Obstet Gynecol"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.11060419.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.13010052.x"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(96)00117-2"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.09060383.x"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(98)00131-8"},{"key":"e_1_2_5_25_2","unstructured":"BlandJM.How should I calculate a within\u2010subject coefficient of variation?http:\/\/www\u2010users.york.ac.uk\/\u223cmb55\/meas\/cv.htm[Accessed 22 September 2005]."},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.78"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2003.025"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01957218"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(00)00041-5"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(98)00323-6"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1744"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2000.0585"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2002.0810"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70442-3"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.034470"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-5629(94)90062-0"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1115\/1.2798014"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000152391.45273.A2"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.2784","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.2784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T08:56:25Z","timestamp":1696668985000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.2784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,12]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1002\/uog.2784"],"URL":"https:\/\/doi.org\/10.1002\/uog.2784","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,12]]},"assertion":[{"value":"2006-01-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}