{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:39:12Z","timestamp":1788957552320,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018712","name":"Universitatea de Medicin\u0103 \u015fi Farmacie Iuliu Ha\u0163ieganu Cluj-Napoca","doi-asserted-by":"publisher","award":["35.166\/17.12.2022"],"award-info":[{"award-number":["35.166\/17.12.2022"]}],"id":[{"id":"10.13039\/501100018712","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the diagnostic accuracy of virtual autopsy using whole\u2010body postmortem ultra\u2010high field magnetic resonance imaging (MRI) at 7\u2009Tesla (T), using a short T2\u2010weighted imaging (T2\u2010WI) protocol, compared with classical autopsy, for detecting structural abnormalities in small second\u2010trimester fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty consecutive fetuses at 13\u201319\u2009weeks' gestation (weight, 17\u2013364\u2009g) were included following spontaneous pregnancy loss or termination of pregnancy. After fixation in 10% formaldehyde solution (48\u2009h to 1\u2009week), all fetuses were scanned using a two\u2010dimensional turbo high\u2010resolution T2\u2010WI protocol with multislice relaxation time, followed by an invasive autopsy. The diagnostic accuracy of virtual autopsy <jats:italic>vs<\/jats:italic> classical autopsy was calculated for 990 anatomical structures (30 fetuses\u2009\u00d7\u200933 items). Sensitivity, specificity, positive and negative predictive values and Cohen's \u03ba coefficient of agreement, with their 95%\u2009CIs, as well as the McNemar test, were used to evaluate the accuracy and agreement of the two diagnostic methods. Analysis was stratified by anatomical segment (nervous, pulmonary, cardiovascular, digestive, renal, facial and skeletal) and across three gestational\u2010age intervals (13\u201314, 15\u201316 and 17\u201319\u2009weeks).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Considering classical autopsy as the gold standard, virtual autopsy had a sensitivity of 92.04% (95%\u2009CI, 85.42\u201396.29%) and a specificity of 97.87% (95%\u2009CI, 94.64\u201399.42%), with a positive predictive value of 96.30% (95%\u2009CI, 90.78\u201398.56%) and a negative predictive value of 95.34% (95%\u2009CI, 91.61\u201397.45%), achieving a diagnostic accuracy of 95.68% (95%\u2009CI, 92.73\u201397.68%) for detecting structural abnormalities in second\u2010trimester fetuses. Cohen's \u03ba for virtual <jats:italic>vs<\/jats:italic> classical autopsy was 0.907. The diagnostic ability of virtual autopsy at 7\u2009T for malformed fetuses was superior to that of classical autopsy for analyzing the nervous system in small fetuses with pronounced autolysis, equivalent to that of classical autopsy when analyzing pulmonary, cardiovascular and renal systems and inferior when evaluating the fetal intestines. The  sensitivity of virtual autopsy at 7\u2009T for describing structural abnormalities increased with gestational age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Virtual fetal autopsy using 7\u2010T MRI and a turbo high\u2010resolution T2\u2010WI protocol with multislice relaxation time  is a feasible postmortem diagnostic tool for the identification of fetal structural anomalies. \u00a9 2024 The Author(s). <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.29106","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T06:48:14Z","timestamp":1728370094000},"page":"661-668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Whole\u2010body non\u2010forensic fetal virtopsy using postmortem magnetic resonance imaging at 7 Tesla <i>vs<\/i> classical autopsy"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3755-320X","authenticated-orcid":false,"given":"A.","family":"Staicu","sequence":"first","affiliation":[{"name":"Mother and Child Department, 1<sup>st<\/sup> Clinic of Obstetrics and Gynaecology \u2018Iuliu Ha\u0163ieganu\u2019 University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Albu","sequence":"additional","affiliation":[{"name":"Department of Pathology \u2018Iuliu Ha\u0163ieganu\u2019 University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"},{"name":"Centre of Advanced Research Studies Emergency County Hospital, IMOGEN  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Popa\u2010Stanila","sequence":"additional","affiliation":[{"name":"Centre of Advanced Research Studies Emergency County Hospital, IMOGEN  Cluj\u2010Napoca Romania"},{"name":"Department of Radiology \u2018Iuliu Ha\u0163ieganu\u2019 University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bondor","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics and Biostatistics \u2018Iuliu Ha\u0163ieganu\u2019 University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Chiriac","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics \u2018Iuliu Ha\u0163ieganu\u2019 University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"},{"name":"National Magnetic Resonance Centre Babe\u0219 Bolyai University  Cluj\u2010Napoca Romania"},{"name":"Faculty of Physics Babe\u0219 Bolyai University  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Eniu","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics \u2018Iuliu Ha\u0163ieganu\u2019 University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Goidescu","sequence":"additional","affiliation":[{"name":"Mother and Child Department, 1<sup>st<\/sup> Clinic of Obstetrics and Gynaecology \u2018Iuliu Ha\u0163ieganu\u2019 University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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