{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:15:07Z","timestamp":1790363707554,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>First, to compare the predictive performance of routine ultrasonographic estimated fetal weight (EFW) at 31\u2009+\u20090 to 33\u2009+\u20096 and 35\u2009+\u20090 to 36\u2009+\u20096\u2009weeks' gestation for delivery of a small\u2010for\u2010gestational\u2010age (SGA) neonate. Second, to compare the predictive performance of EFW at 36\u2009weeks' gestation for SGA <jats:italic>vs<\/jats:italic> fetal growth restriction (FGR) at birth. Third, to compare the predictive performance for delivery of a SGA neonate of EFW &lt;\u200910<jats:sup>th<\/jats:sup> percentile <jats:italic>vs<\/jats:italic> a model combining maternal demographic characteristics and elements of medical history with EFW.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective analysis of prospectively collected data in 21\u2009676 women with a singleton pregnancy who had undergone routine ultrasound examination at 31\u2009+\u20090 to 33\u2009+\u20096\u2009weeks' gestation and 107\u2009875 women with a singleton pregnancy who had undergone routine ultrasound examination at 35\u2009+\u20090 to 36\u2009+\u20096\u2009weeks. Measurements of fetal head circumference, abdominal circumference and femur length were used to calculate EFW according to the Hadlock formula and this was expressed as a percentile according to the Fetal Medicine Foundation fetal and neonatal population weight charts. The same charts were used to diagnose SGA neonates with birth weight &lt;\u200910<jats:sup>th<\/jats:sup> or &lt;\u20093<jats:sup>rd<\/jats:sup> percentile. FGR was defined as birth weight &lt;\u200910<jats:sup>th<\/jats:sup> percentile in addition to Doppler anomalies. For each gestational\u2010age window at screening, the screen\u2010positive rate and detection rate were calculated at different EFW cut\u2010offs between the 10<jats:sup>th<\/jats:sup> and 50<jats:sup>th<\/jats:sup> percentiles for predicting the delivery of a SGA neonate with birth weight &lt;\u200910<jats:sup>th<\/jats:sup> or &lt;\u20093<jats:sup>rd<\/jats:sup> percentile, either within 2\u2009weeks or at any time after assessment. The areas under the receiver\u2010operating\u2010characteristics curves (AUC) of screening for a SGA neonate by EFW at 31\u2009+\u20090 to 33\u2009+\u20096\u2009weeks and at 35\u2009+\u20090 to 36\u2009+\u20096\u2009weeks were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The predictive performance of routine ultrasonographic examination during the third trimester for delivery of a SGA neonate is higher if: first, the scan is carried out at 35\u2009+\u20090 to 36\u2009+\u20096\u2009weeks' gestation rather than at 31\u2009+\u20090 to 33\u2009+\u20096\u2009weeks; second, the outcome measure is birth weight &lt;\u20093<jats:sup>rd<\/jats:sup> rather than &lt;\u200910<jats:sup>th<\/jats:sup> percentile; third, the outcome measure is FGR rather than SGA; fourth, if delivery occurs within 2\u2009weeks after assessment rather than at any time after assessment; and fifth, prediction is performed using a model that combines maternal demographic characteristics and elements of medical history with EFW rather than EFW &lt;\u200910<jats:sup>th<\/jats:sup> percentile alone. At 35\u2009+\u20090 to 36\u2009+\u20096\u2009weeks' gestation, detection of \u2265\u200985% of SGA neonates with birth weight &lt;\u200910<jats:sup>th<\/jats:sup> percentile born at any time after assessment necessitates the use of EFW &lt;\u200940<jats:sup>th<\/jats:sup> percentile. Screening at this percentile cut\u2010off predicted 95% and 98% of neonates with birth weight &lt;\u200910<jats:sup>th<\/jats:sup> and &lt;\u20093<jats:sup>rd<\/jats:sup> percentile, respectively, born within 2\u2009weeks after assessment, and the respective values for neonates born at any time after assessment were 85% and 93%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Routine third\u2010trimester ultrasonographic screening for a SGA neonate performs best when the scan is carried out at 35\u2009+\u20090 to 36\u2009+\u20096\u2009weeks' gestation, rather than at 31\u2009+\u20090 to 33\u2009+\u20096\u2009weeks, and when EFW is combined with maternal risk factors to estimate the patient\u2010specific risk. \u00a9 2024 The Author(s). <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.29134","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T15:43:17Z","timestamp":1732549397000},"page":"20-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Routine 36\u2010week scan: prediction of small\u2010for\u2010gestational\u2010age neonate"],"prefix":"10.1002","volume":"65","author":[{"given":"S.","family":"Adjahou","sequence":"first","affiliation":[{"name":"Fetal Medicine Research Institute King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5856-6072","authenticated-orcid":false,"given":"A.","family":"Syngelaki","sequence":"additional","affiliation":[{"name":"Fetal Medicine Research Institute King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nanda","sequence":"additional","affiliation":[{"name":"Fetal Medicine Research Institute King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Papavasileiou","sequence":"additional","affiliation":[{"name":"Fetal Medicine Research Institute King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7265-5442","authenticated-orcid":false,"given":"R.","family":"Akolekar","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Medway Maritime Hospital  Gillingham UK"},{"name":"Institute of Medical Sciences Canterbury Christ Church University  Chatham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1266-0711","authenticated-orcid":false,"given":"K. 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