{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:20:16Z","timestamp":1779196816457,"version":"3.51.4"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T00:00:00Z","timestamp":1733529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the effectiveness and cost of <jats:italic>in\u2010vitro<\/jats:italic> fertilization (IVF) with or without preimplantation genetic testing for aneuploidy (PGT\u2010A) when only one or two blastocysts are obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A dataset was gathered from 1829 patients including 368 non\u2010PGT\u2010A and 1461 PGT\u2010A cycles with one or two blastocysts obtained, between April 2013 and July 2022. Patients were matched 1:1 by propensity\u2010score matching for maternal age, number of metaphase\u2010II oocytes inseminated and number of blastocysts obtained, achieving a database of 242 patients per group. The non\u2010PGT\u2010A and PGT\u2010A groups were compared for differences in live birth rate (LBR) per embryo transfer (ET), cumulative LBR per patient, miscarriage rate (MR) per clinical pregnancy, number of days between oocyte retrieval and conclusion of the IVF cycle (primary outcome), mean expenses incurred at the clinic and incremental cost\u2010effectiveness ratio (ICER).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>More than twice as many ETs were conducted in the non\u2010PGT\u2010A group compared with the PGT\u2010A group, yet the cumulative LBR per patient was similar between groups (23.6% (95%\u2009CI, 18.5\u201329.5%) <jats:italic>vs<\/jats:italic> 27.3% (95%\u2009CI, 21.9\u201333.4%)). This outcome was achieved with a higher LBR per ET (16.2% (95%\u2009CI, 12.6\u201320.5%) <jats:italic>vs<\/jats:italic> 41.5% (95%\u2009CI, 33.9\u201349.4%)) and lower MR per clinical pregnancy (30.1% (95%\u2009CI, 21.8\u201342.6%) <jats:italic>vs<\/jats:italic> 13.9% (95%\u2009CI, 7.5\u201324.0%)) in the PGT\u2010A group. The MR per patient was also lower in the PGT\u2010A group (9.5% (95%\u2009CI, 6.2\u201314.1%) <jats:italic>vs<\/jats:italic> 4.5% (95%\u2009CI, 2.4\u20138.2%)). The mean duration between oocyte retrieval and IVF cycle conclusion was 131 (95%\u2009CI, 113\u2013150)\u2009days in the non\u2010PGT\u2010A group <jats:italic>vs<\/jats:italic> 74 (95%\u2009CI, 61\u201387)\u2009days in the PGT\u2010A group (<jats:italic>P\u2009&lt;<\/jats:italic>\u20090.001; power\u2009=\u200999.8%). The ICER of PGT\u2010A for the months saved between oocyte retrieval and conclusion of the IVF cycle was \u20ac499 overall, ranging between \u20ac170 and \u20ac2065 according to the number of blastocysts obtained and\/or maternal age. The ICER of PGT\u2010A for prevented miscarriages was \u20ac18\u2009968, decreasing to \u20ac3525 when calculated among patients aged \u2265\u200935\u2009years with two blastocysts obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>When conducted in expert IVF clinics for patients indicated for the procedure, PGT\u2010A is clinically valuable even when only one or two blastocysts are obtained. PGT\u2010A reduces the number of ETs and miscarriages while the cumulative LBR per patient remains unaffected, and allows these outcomes to be achieved in a shorter timeframe. The ICER of PGT\u2010A <jats:italic>vs<\/jats:italic> non PGT\u2010A decreased as maternal age increased. \u00a9 2024 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.29148","type":"journal-article","created":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T15:28:32Z","timestamp":1733585312000},"page":"106-113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Value of <scp>PGT<\/scp>\u2010A when only one or two blastocysts are obtained: propensity\u2010score matching and cost\u2010effectiveness study"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5390-9221","authenticated-orcid":false,"given":"D.","family":"Cimadomo","sequence":"first","affiliation":[{"name":"IVIRMA Global Research Alliance, GENERA, Clinica Valle Giulia  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Taggi","sequence":"additional","affiliation":[{"name":"IVIRMA Global Research Alliance, GENERA, Clinica Valle Giulia  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Cimadomo","sequence":"additional","affiliation":[{"name":"DLL  Eindhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Innocenti","sequence":"additional","affiliation":[{"name":"IVIRMA Global Research Alliance, GENERA, Clinica Valle Giulia  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Albricci","sequence":"additional","affiliation":[{"name":"IVIRMA Global Research Alliance, GENERA, Clinica Valle Giulia  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Colamaria","sequence":"additional","affiliation":[{"name":"IVIRMA Global Research Alliance, GENERA, Clinica Valle Giulia  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Argento","sequence":"additional","affiliation":[{"name":"IVIRMA Global Research Alliance, GENERA, Clinica Valle Giulia  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Giuliani","sequence":"additional","affiliation":[{"name":"IVIRMA Global Research Alliance, GENERA, Clinica Valle Giulia  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ferrero","sequence":"additional","affiliation":[{"name":"IVIRMA Global Research Alliance, GENERA, Clinica Valle Giulia  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Borini","sequence":"additional","affiliation":[{"name":"IVIRMA Global Research Alliance  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Guido","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences University of Calabria  Rende Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"Campitiello","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Physiopathology of Human Reproduction, ASL Salerno  Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. M.","family":"Ubaldi","sequence":"additional","affiliation":[{"name":"IVIRMA Global Research Alliance, GENERA, Clinica Valle Giulia  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Capalbo","sequence":"additional","affiliation":[{"name":"Juno Genetics  Rome Italy"},{"name":"Unit of Molecular Genetics, Center for Advanced Studies and Technology (CAST), \u2018G. 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