{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:56:13Z","timestamp":1757616973018,"version":"3.44.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the performance of the Fetal Medicine Foundation (FMF) first\u2010trimester competing\u2010risks screening model for small\u2010for\u2010gestational\u2010age (SGA) fetuses requiring delivery at &lt;\u200937\u2009weeks' gestation, in a large cohort of women receiving maternity care in Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective analysis of prospectively collected data from a cohort of women attending one of two private multicenter fetal medicine practices for first\u2010trimester screening for preterm pre\u2010eclampsia (PE), defined as PE requiring delivery before 37\u2009weeks' gestation. Risk for preterm SGA, defined as SGA requiring delivery before 37\u2009weeks, was calculated but was not disclosed to the patient or referring physician. Screening data were matched to obstetric outcomes. The primary outcome was the efficacy of the FMF screening model in assessing the risk of preterm SGA. The potential effect on identifying other adverse pregnancy outcomes was also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, 22\u2009841 women with a singleton pregnancy underwent combined first\u2010trimester screening for preterm PE. These data were compared with those of 301\u2009721 women in the state of Victoria with a singleton pregnancy who did not undergo screening during the study period. Calculation of the risk for preterm SGA identified 3030 (13.3%) pregnancies as high risk. The sensitivity of the model was 48.6% (95%\u2009CI, 41.0\u201356.2%), specificity was 87.0% (95%\u2009CI, 86.6\u201387.5%) and positive and negative predictive values were 2.9% (95%\u2009CI, 2.7\u20133.1%) and 99.5% (95%\u2009CI, 99.4\u201399.6%), respectively. Pregnancies at high risk for preterm SGA were also more likely to have preterm PE (risk ratio (RR), 2.28 (95%\u2009CI, 1.72\u20133.03)) and preterm birth (RR, 1.46 (95%\u2009CI, 1.32\u20131.63)), compared with unscreened pregnancies. Pregnancies at low risk for preterm SGA were less likely to result in a stillbirth (RR, 0.64 (95%\u2009CI, 0.47\u20130.86)) compared with unscreened pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Combined first\u2010trimester screening for preterm SGA shows moderate screening efficacy and therefore could help to inform pregnancy management and improve antenatal resource allocation. \u00a9 2025 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.29174","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T09:33:19Z","timestamp":1737192799000},"page":"183-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined first\u2010trimester screening for preterm small\u2010for\u2010gestational\u2010age infants: Australian multicenter clinical feasibility study"],"prefix":"10.1002","volume":"65","author":[{"given":"R. J.","family":"Selvaratnam","sequence":"first","affiliation":[{"name":"The Ritchie Centre, Department of Obstetrics and Gynaecology Monash University  Victoria Australia"},{"name":"Safer Care Victoria, Department of Health and Human Services Victorian Government  Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2263-3592","authenticated-orcid":false,"given":"D. L.","family":"Rolnik","sequence":"additional","affiliation":[{"name":"The Ritchie Centre, Department of Obstetrics and Gynaecology Monash University  Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Setterfield","sequence":"additional","affiliation":[{"name":"Discipline of Obstetrics, Gynaecology and Neonatology, Faculty of Medicine and Health University of Sydney  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. M.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Health and Human Services  Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8019-1289","authenticated-orcid":false,"given":"J. A.","family":"Hyett","sequence":"additional","affiliation":[{"name":"The Obstetric Research Group The Ingham Institute and Western Sydney University  Liverpool NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0765-7780","authenticated-orcid":false,"given":"F.","family":"da Silva Costa","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine Unit, Gold Coast University Hospital and School of Medicine Griffith University  Gold Coast Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8979-4534","authenticated-orcid":false,"given":"A. C.","family":"McLennan","sequence":"additional","affiliation":[{"name":"Discipline of Obstetrics, Gynaecology and Neonatology, Faculty of Medicine and Health University of Sydney  Sydney NSW Australia"},{"name":"Sydney Ultrasound for Women  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16038"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.15310"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.8608"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50658"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15884"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2016.10.006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22134"},{"key":"e_1_2_7_9_1","article-title":"The Investigation and Management of the Small\u2013for\u2013Gestational\u2013Age Fetus (Green\u2010top Guideline No. 31) 2nd ed","author":"Royal College of Obstetricians and Gynaecologists","year":"2014","journal-title":"RCOG"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-020-03401-0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341712"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15919"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23118"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19077"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16815"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12951"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.14049"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14783"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14789"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14870"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14811"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50676"},{"key":"e_1_2_7_23_1","unstructured":"Index of relative socio\u2010economic advantage and disadvantage.Australian Bureau of Statistics.2018https:\/\/www.abs.gov.au\/ausstats\/abs@.nsf\/Lookup\/by%20Subject\/2033.0.55.001\u223c2016\u223cMain%20Features\u223cIRSAD\u223c20. 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