{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:58:31Z","timestamp":1790125111813,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the performance of a standardized first\u2010trimester ultrasound screening strategy for fetal congenital heart disease (CHD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a large retrospective study involving 74\u2009839 consecutive mixed\u2010risk pregnancies (77\u2009396  fetuses). Routine ultrasound scans at 11\u2009+\u20090 to 13\u2009+\u20096\u2009weeks' gestation were performed in a single center from January 2015 to June 2023. All fetuses were examined using a predefined standardized ultrasound scanning strategy with adjustment of imaging parameters, which included assessment of the fetal heart. The ultrasound results (e.g. extracardiac congenital malformations), ultrasound markers (e.g. nuchal translucency thickening, reversed a\u2010wave in the ductus venosus and tricuspid regurgitation), follow\u2010up, genetic tests and diagnostic results were recorded and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, there were 831 cases of CHD, with an incidence of 1.07% (831\/77\u2009396). In the first\u2010trimester scan, 590 fetuses were diagnosed with CHD, but four were confirmed as normal in later examinations. In addition,  245 cases were missed. The detection rate was 70.52%, with a sensitivity, specificity, false\u2010positive rate and false\u2010negative rate of 70.52%, 99.99%, 0.01% and 29.48%, respectively. In fetuses with negative ultrasound markers and no extracardiac malformations, the detection rate of CHD was 45.79% (185\/404). There were 281 cases that underwent karyotyping and chromosomal microarray (245 fetuses) or whole\u2010exome sequencing (36 fetuses). In total, 38.79% (109\/281) had a positive genetic test result. There were 273\/831 CHD cases associated with extracardiac malformations. The abnormal image patterns and abnormal features of each view in the scanning strategy were summarized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ultrasound screening for fetal CHD in the first trimester of pregnancy enables earlier prenatal diagnosis and consultation. The standardized ultrasound screening strategy used in this study had a high detection rate for fetal CHD in the first trimester. Our proposed fetal heart screening strategy shows promising effectiveness for early diagnosis of CHD and we recommend its use. It is important to note, however, that first\u2010trimester ultrasound screening for fetal CHD should not replace fetal echocardiography in the second trimester. \u00a9 2025 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.29186","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T16:14:36Z","timestamp":1741709676000},"page":"478-486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of first\u2010trimester ultrasound screening strategy for fetal congenital heart disease"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4493-8469","authenticated-orcid":false,"given":"S.","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Guangxi Provincial Clinical Medical Research Center for Birth Defects Guangxi Key Laboratory of Reproductive Health and Birth Defects Prevention and Control  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Guangxi Provincial Clinical Medical Research Center for Birth Defects Guangxi Key Laboratory of Reproductive Health and Birth Defects Prevention and Control  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"He","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Guangxi Provincial Clinical Medical Research Center for Birth Defects Guangxi Key Laboratory of Reproductive Health and Birth Defects Prevention and Control  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Guangxi Provincial Clinical Medical Research Center for Birth Defects Guangxi Key Laboratory of Reproductive Health and Birth Defects Prevention and Control  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Guangxi Provincial Clinical Medical Research Center for Birth Defects Guangxi Key Laboratory of Reproductive Health and Birth Defects Prevention and Control  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Guangxi Provincial Clinical Medical Research Center for Birth Defects Guangxi Key Laboratory of Reproductive Health and Birth Defects Prevention and Control  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Guangxi Provincial Clinical Medical Research Center for Birth Defects Guangxi Key Laboratory of Reproductive Health and Birth Defects Prevention and Control  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Guangxi Provincial Clinical Medical Research Center for Birth Defects Guangxi Key Laboratory of Reproductive Health and Birth Defects Prevention and Control  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Guangxi Provincial Clinical Medical Research Center for Birth Defects Guangxi Key Laboratory of Reproductive Health and Birth Defects Prevention and Control  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Guangxi Provincial Clinical Medical Research Center for Birth Defects Guangxi Key Laboratory of Reproductive Health and Birth Defects Prevention and Control  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12852"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000455947"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2013.05.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3948"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26224"},{"issue":"1","key":"e_1_2_7_8_1","first-page":"1","article-title":"Practice guidelines for performance of prenatal ultrasound screening","volume":"31","author":"Group of Ultrasound in Obstetrics and Gynecology, Ultrasound Branch of Chinese Medical Association, Medical Imaging Group of the National Prenatal Diagnosis Expert Group, Department of Maternal and Child, National Health Commission of the People's Republic of China","year":"2022","journal-title":"Chin J Ultrasonogr"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.372"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00739.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00733.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3948"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-105514"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.10.037"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12342"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15477"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26106"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23572"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6391"},{"key":"e_1_2_7_20_1","volume-title":"First Trimester Ultrasound Diagnosis of Fetal Abnormalities","author":"Abuhamad AZ","year":"2017"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.23651"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2012.31.4.563"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1414"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/njcp.njcp_757_22"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1637849"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.21956"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8934"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23740"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15123"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26094"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.23330"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10153206"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14533"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20844"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.183056"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.29186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T21:44:17Z","timestamp":1751579057000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.29186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,28]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/uog.29186"],"URL":"https:\/\/doi.org\/10.1002\/uog.29186","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,28]]},"assertion":[{"value":"2024-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}