{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:45:58Z","timestamp":1792446358184,"version":"4.5.0"},"reference-count":63,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the performance of sonographic fetal biometry and Doppler parameters assessed at routine third\u2010trimester ultrasound examination for predicting small\u2010for\u2010gestational age (SGA) and fetal growth restriction (FGR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a retrospective cohort study of low\u2010risk singleton pregnancies undergoing routine ultrasound examination between 35\u2009+\u20090 and 37\u2009+\u20096\u2009weeks' gestation and delivered at St George's University Hospital, London, UK, between December 2019 and February 2024. The study outcomes were SGA (birth weight\u2009&lt;\u20095\n                      <jats:sup>th<\/jats:sup>\n                      centile) and FGR (birth weight\u2009&lt;\u20093\n                      <jats:sup>rd<\/jats:sup>\n                      centile or birth weight &lt;\u200910\n                      <jats:sup>th<\/jats:sup>\n                      centile with  composite adverse perinatal outcome). Composite adverse perinatal outcome comprised intrauterine death, neonatal death or admission to the neonatal intensive care unit. Demographic characteristics, estimated fetal weight (EFW) and abdominal circumference centiles, as well as Doppler indices, including pulsatility indices (PI) of the umbilical artery (UA), middle cerebral artery (MCA) and uterine artery (UtA) were evaluated. The cerebroplacental ratio (CPR) was calculated, and all indices were converted to multiples of the median (MoM). Multivariable logistic regression analysis was performed to identify and adjust for confounders. The area under the receiver\u2010operating\u2010characteristics curve (AUC) was used to evaluate the model's performance for predicting small neonates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 14\u2009161 pregnancies were included in the study. The prevalence of SGA and FGR neonates was 3.1% and 1.5%, respectively. Independent predictors of SGA and FGR, respectively, were: EFW centile (adjusted odds ratio (aOR) 0.91 (95%\u2009CI, 0.90\u20130.92);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001 and aOR 0.90 (95%\u2009CI, 0.89\u20130.91);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001); AC centile (aOR\u20090.91 (95%\u2009CI, 0.90\u20130.92);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001 and aOR\u20090.91 (95%\u2009CI, 0.90\u20130.92);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;0.001); UA\u2010PI MoM (aOR 4.60 (95%\u2009CI, 2.19\u20139.64);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001 and aOR 2.53 (95%\u2009CI, 1.05\u20136.10);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.038); MCA\u2010PI MoM (aOR 0.37 (95%\u2009CI, 0.20\u20130.70);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002 and aOR 0.26 (95%\u2009CI, 0.12\u20130.59);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001); CPR MoM (aOR 0.23 (95%\u2009CI, 0.13\u20130.42);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001 and aOR 0.25 (95%\u2009CI, 0.12\u20130.53);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001); and UtA\u2010PI MoM (aOR 2.54 (95%\u2009CI, 1.68\u20133.83);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001 and aOR 2.16 (95%\u2009CI, 1.31\u20133.58);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003). The EFW centile alone was associated with an AUC of 0.917 (95%\u2009CI, 0.907\u20130.929) for the prediction of SGA and 0.925 (95%\u2009CI, 0.908\u20130.939) for the prediction of FGR. This was similar to AUCs of around 0.92 for the prediction of SGA and AUCs of around 0.93 for the prediction of FGR when the EFW centile was combined with any Doppler parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Sonographic fetal biometry evaluation in the late third trimester can predict delivery of a neonate affected by SGA or FGR, including those at risk for adverse perinatal outcomes. In an unselected population, fetal arterial Doppler parameters were independent predictors of SGA and FGR, but the addition of Doppler parameters to fetal biometry did not improve prediction of the incidence of small neonates. \u00a9 2025 The Author(s).\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.29223","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T13:44:17Z","timestamp":1745675057000},"page":"761-770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prediction of small\u2010for\u2010gestational age and fetal growth restriction at routine ultrasound examination at 35\u201337 weeks' gestation"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5304-2296","authenticated-orcid":false,"given":"M.","family":"Lopian","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2329-4470","authenticated-orcid":false,"given":"S.","family":"Prasad","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Segal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Sheba Medical Center, Tel Hashomer  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dotan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Sheba Medical Center, Tel Hashomer  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7931-5172","authenticated-orcid":false,"given":"C. 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