{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:52:09Z","timestamp":1785423129807,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The ultrasound diagnosis of placental site trophoblastic tumor (PSTT) is challenging owing to a lack of pathognomonic features. Differential diagnosis from other forms of gestational trophoblastic neoplasia (GTN) is critical owing to major differences in prognosis and treatment. Doppler measurement of uterine artery (UtA) pulsatility index (PI) has been proposed for the diagnosis and management of GTN. The aim of this study was to evaluate the added value of UtA\u2010PI Doppler measurement during the standard transvaginal ultrasound (TVS) assessment, in patients with PSTT as compared to those with other GTN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a single\u2010center prospective cohort study involving ultrasound assessment of all GTN cases referred to and treated at the trophoblast unit of San Raffaele Hospital, Milan, Italy, between 2011 and 2023. TVS assessment included: grayscale analysis for the detection of myometrial or endometrial abnormalities, color and power Doppler assessment of lesions with scoring of vascularization, and spectral pulsed\u2010wave Doppler for measurement of mean UtA\u2010PI from the left and right UtAs. Sonographic findings were compared between patients with PSTT and those with other forms of GTN (postmolar, invasive mole or choriocarcinoma), using non\u2010parametric two\u2010tailed statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 73 GTN cases were recruited, comprising nine (12.3%) with PSTT and 64 (87.7%) with other GTN. A significant difference was detected between other\u2010GTN and PSTT cases when comparing rates of substantial endometrial vascularity on  Doppler (50%\n                      <jats:italic>vs<\/jats:italic>\n                      0%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.013) and mean UtA\u2010PI measurements (median, 1.5 (interquartile range (IQR), 1.0\u20132.4)\n                      <jats:italic>vs<\/jats:italic>\n                      2.2 (IQR, 1.5\u20132.7);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.014; area under the receiver\u2010operating\u2010characteristics curve, 0.768 (95%\u2009CI, 0.610\u20130.888)).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study describes UtA\u2010PI as a novel and effective marker allowing for the ultrasound differentiation of PSTT from other forms of GTN. The significantly higher mean UtA\u2010PI and lower endometrial vascularity observed in PSTT as compared with other GTN suggests a unique vascularization pattern, with a potential role in differential diagnosis and management. \u00a9 2025 The Author(s).\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.29235","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T07:57:26Z","timestamp":1747641446000},"page":"73-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Additional value of uterine artery Doppler pulsatility index for ultrasound diagnosis of placental site trophoblastic tumor: prospective cohort study"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4370-8271","authenticated-orcid":false,"given":"R.","family":"Cioffi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology IRCCS San Raffaele Hospital  Milan Italy"},{"name":"School of Medicine and Surgery, Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8097-366X","authenticated-orcid":false,"given":"P. I.","family":"Cavoretto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology IRCCS San Raffaele Hospital  Milan Italy"},{"name":"School of Medicine and Surgery, Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Sabetta","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology IRCCS San Raffaele Hospital  Milan Italy"},{"name":"School of Medicine and Surgery, Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1915-8313","authenticated-orcid":false,"given":"A.","family":"Bergamini","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology IRCCS San Raffaele Hospital  Milan Italy"},{"name":"School of Medicine and Surgery, Vita\u2010Salute San Raffaele University  Milan 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