{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:12:11Z","timestamp":1791396731992,"version":"4.3.3"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["JR19\/00047"],"award-info":[{"award-number":["JR19\/00047"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/00702"],"award-info":[{"award-number":["PI19\/00702"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD21\/0012\/0001"],"award-info":[{"award-number":["RD21\/0012\/0001"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Women diagnosed with pre\u2010eclampsia (PE), especially those with early\u2010onset and severe forms, are at heightened risk of future cardiovascular disease. However, it is uncertain if women at high risk for PE present cardiovascular impairment at the beginning of pregnancy. The aim of this study was to assess cardiovascular biomarkers and cardiac function in the first half of pregnancy in women at high risk for PE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective cohort study including women attending first\u2010trimester screening for PE at a single center in Spain, between July 2020 and April 2023. The risk of PE in the first trimester was calculated using a previously validated model that includes maternal factors and biophysical markers. A cut\u2010off of 1 in 250 was used to classify high risk for developing PE. Maternal echocardiographic function and morphometry were evaluated, and peripheral blood samples were obtained to assess hematological and biochemical variables, including lipid profile and cardiovascular and angiogenic factors. Findings were compared between women at high risk and those at low risk for PE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 349 pregnant individuals were included, 257 at high risk and 92 at low risk for PE. Maternal echocardiography was performed at a mean\u2009\u00b1\u2009SD gestational age of 14.9\u2009\u00b1\u20091.3\u2009weeks and blood sampling at 16.3\u2009\u00b1\u20091.9\u2009weeks. The high\u2010risk PE group exhibited a  worse lipid profile (significantly lower levels of high\u2010density lipoprotein (69.7\u2009\u00b1\u200914.2\n                      <jats:italic>vs<\/jats:italic>\n                      74.0\u2009\u00b1\u200914.6\u2009mg\/dL;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.020), significantly lower placental growth factor multiples of the median (0.89\u2009\u00b1\u20090.63\n                      <jats:italic>vs<\/jats:italic>\n                      1.15\u2009\u00b1\u20090.58;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and significantly lower levels of N\u2010terminal pro B\u2010type  natriuretic peptide (51.0\u2009\u00b1\u20092.1\n                      <jats:italic>vs<\/jats:italic>\n                      52.1\u2009\u00b1\u20092.0\u2009ng\/L;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.008)). Echocardiographic evaluation indicated concentric remodeling along with an altered diastolic pattern in the high\u2010risk group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Women at high risk of developing PE exhibit differences in lipid profile, angiogenic factors and echocardiographic parameters, indicative of cardiac maladaptation or impairment during the first half of pregnancy. These findings suggest a link between subclinical cardiovascular dysfunction, PE development and later cardiovascular disease risk. \u00a9 2025 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.29247","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T10:57:47Z","timestamp":1749121067000},"page":"65-72","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cardiovascular risk assessment in women at high risk for pre\u2010eclampsia in first half of pregnancy"],"prefix":"10.1002","volume":"66","author":[{"given":"J.","family":"Ullmo","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Hospital de la Santa Creu i Sant Pau, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Women and Perinatal Health Research Group, Institut de Recerca (IR SANT PAU)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6807-3578","authenticated-orcid":false,"given":"M.","family":"Cruz\u2010Lemini","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hospital de la Santa Creu i Sant Pau, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Women and Perinatal Health Research Group, Institut de Recerca (IR SANT PAU)  Barcelona Spain"},{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS\u2010SAMID, RD21\/0012\/0001) and Maternal and Child Health Development Network (SAMID, RD16\/0022\/0015), Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Bos\u2010Real","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital de la Santa Creu i Sant Pau, IIB\u2010SantPau, Universidad Aut\u00f3noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Padilla","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital de la Santa Creu i Sant Pau, IIB\u2010SantPau, Universidad Aut\u00f3noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Coma\u2010Barbar\u00e0","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hospital de la Santa Creu i Sant Pau, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Martorell","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hospital de la Santa Creu i Sant Pau, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mora","sequence":"additional","affiliation":[{"name":"Women and Perinatal Health Research Group, Institut de Recerca (IR SANT PAU)  Barcelona Spain"},{"name":"Department of Clinical Biochemistry Hospital de la Santa Creu i Sant Pau, Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ordo\u00f1ez\u2010Llanos","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Hospital de la Santa Creu i Sant Pau, Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau  Barcelona Spain"},{"name":"Fundaci\u00f3 per la Bioqu\u00edmica i la Patolog\u00eda Molecular, Biochemistry Department Santa Creu i Sant Pau University Hospital, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4048-6407","authenticated-orcid":false,"given":"E.","family":"Llurba","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hospital de la Santa Creu i Sant Pau, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Women and Perinatal Health Research Group, Institut de Recerca (IR SANT PAU)  Barcelona Spain"},{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS\u2010SAMID, RD21\/0012\/0001) and Maternal and Child Health Development Network (SAMID, RD16\/0022\/0015), Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"AngioCor working group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30977-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00684-X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-015-0694-y"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.931943"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113055"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16678"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17495"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu018"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200102000-00018"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17410"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013545"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-04263-w"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12081814"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew082"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00440.2016"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-4035-z"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14102087"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021160"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12040795"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.31486\/toj.21.0026"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01787"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20110671"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15830"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3329\/bmrcb.v36i1.4806"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.066199"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2012.05.004"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-016-9544-9"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2020-001293"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2021.5617"},{"key":"e_1_2_7_32_1","first-page":"1","article-title":"Early\u2010pregnancy N\u2010terminal pro\u2010brain natriuretic peptide level is inversely associated with hypertensive disorders of pregnancy","volume":"11","author":"Takahashi M","year":"2024","journal-title":"Res Sq"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.04.051"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.162321"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003664"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26306"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.5.1209"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.054"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11936-021-00930-5"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.29247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T18:56:05Z","timestamp":1765479365000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.29247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,5]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/uog.29247"],"URL":"https:\/\/doi.org\/10.1002\/uog.29247","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,5]]},"assertion":[{"value":"2024-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}