{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:14:26Z","timestamp":1783476866264,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of the present study was to evaluate adverse perinatal outcomes in low\u2010risk singleton pregnancies with borderline oligohydramnios.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was conducted for observational cohort studies that compared perinatal outcomes in low\u2010risk singleton pregnancies between those with borderline oligohydramnios, defined as an amniotic fluid index (AFI) of 5.1\u20138.0\u2009cm, and those with a normal AFI. EMBASE, MEDLINE and Web of Science databases were searched for studies published from inception to July 2024. The quality of the studies was assessed using the Newcastle\u2013Ottawa Scale. Meta\u2010analyses were performed using a random\u2010effects model to calculate pooled proportions and 95%\u2009CIs for each outcome in both groups. The outcomes assessed included overall Cesarean delivery (CD), CD owing to fetal distress, 5\u2010min Apgar score &lt;\u20097, low birth weight (LBW), admission to the neonatal intensive care unit (NICU), meconium\u2010stained amniotic fluid, meconium aspiration syndrome, non\u2010reassuring fetal heart rate during labor, operative vaginal delivery and neonatal death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The search yielded 6902 results, of which eight met the inclusion criteria for the meta\u2010analysis. From these eight studies, 799 singleton pregnancies with borderline oligohydramnios and 1512 singleton pregnancies with normal AFI were analyzed. Analysis revealed an association of borderline oligohydramnios with increased risks of overall CD (odds ratio (OR), 2.20 (95%\u2009CI, 1.70\u20132.84);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01), CD owing to fetal distress (OR, 2.70 (95%\u2009CI, 1.70\u20134.30);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01), 5\u2010min Apgar score &lt;\u20097 (OR, 2.18 (95%\u2009CI, 1.38\u20133.44);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01), LBW (OR, 2.32 (95%\u2009CI, 1.27\u20134.25);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01) and NICU admission (OR, 2.63 (95%\u2009CI, 1.63\u20134.24);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01), compared with normal AFI. A sensitivity analysis that included only term pregnancies revealed significantly higher risks of overall CD, CD owing to fetal distress, LBW and NICU admission in those with borderline oligohydramnios compared to those with normal AFI. Among the pregnancies in which AFI was measured within 1\u2009week before delivery, the risks of overall CD and CD owing to fetal distress were significantly higher.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      We report an association of borderline oligohydramnios with adverse perinatal outcomes among low\u2010risk singleton pregnancies. The increased risks of these perinatal outcomes highlight the need for more frequent monitoring in pregnancies with borderline oligohydramnios. Further research is required to understand the potential benefits and risks of early labor induction and to develop specific guidelines for managing borderline oligohydramnios. \u00a9 2025 The Author(s).\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.29286","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T13:24:04Z","timestamp":1753190644000},"page":"562-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between borderline amniotic fluid levels and adverse perinatal outcome: systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5270-8436","authenticated-orcid":false,"given":"I.","family":"Sgayer","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Galilee Medical Center  Nahariya Israel"},{"name":"Azrieli Faculty of Medicine Bar Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. S.","family":"Kayal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Galilee Medical Center  Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ganem","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Galilee Medical Center  Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. F.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Galilee Medical Center  Nahariya Israel"},{"name":"Azrieli Faculty of Medicine Bar Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lowenstein","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Galilee Medical Center  Nahariya Israel"},{"name":"Azrieli Faculty of Medicine Bar Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Odeh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Galilee Medical Center  Nahariya Israel"},{"name":"Azrieli Faculty of Medicine Bar Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.04.016"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15929"},{"issue":"8","key":"e_1_2_6_4_1","first-page":"601","article-title":"Amniotic fluid index measurements during pregnancy","volume":"32","author":"Phelan JP","year":"1987","journal-title":"J Reprod Med"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-006-0309-x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70037-2"},{"issue":"8","key":"e_1_2_6_7_1","first-page":"743","article-title":"Decreased amniotic fluid index in low\u2010risk pregnancy","volume":"46","author":"Kreiser D","year":"2001","journal-title":"J Reprod Med"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182056766"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1364722"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1004051"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004407"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n160"},{"key":"e_1_2_6_14_1","unstructured":"WellsGA SheaB O'ConnellD et al.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomised studies inmeta\u2010analyses.http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.aspAccessed August 25 2018."},{"issue":"1","key":"e_1_2_6_15_1","first-page":"63","article-title":"Perinatal outcome of term pregnancies with borderline amniotic fluid index at Nepal Medical College and Teaching Hospital","volume":"17","author":"Giri A","year":"2015","journal-title":"Nepal Med Coll J"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.29252\/ijrm.14.11.705"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.33314\/jnhrc.v18i4.3051"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3126\/kumj.v19i1.49529"},{"issue":"11","key":"e_1_2_6_19_1","article-title":"Comparison of perinatal and maternal outcomes in borderline versus normal amniotic fluid index in a tertiary care center in odisha: an observational prospective study","volume":"13","author":"Vyas A","year":"2021","journal-title":"Cureus"},{"issue":"1","key":"e_1_2_6_20_1","first-page":"59","article-title":"Perinatal outcomes of pregnancies with borderline oligohydramnios at term","volume":"52","author":"Sgayer I","year":"2025","journal-title":"Fetal Diagn Ther"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004447"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445948"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.27538"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14924"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.10.889"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.21153"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445946"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14876"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144334"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000534816"},{"issue":"2","key":"e_1_2_6_31_1","first-page":"124","article-title":"The effect of sildenafil on pregnancy outcomes in pregnant women with idiopathic borderline oligohydramnios: a randomized controlled trial","volume":"16","author":"Vahid Dastjerdi M","year":"2022","journal-title":"J Family Reprod Health"}],"container-title":["Ultrasound in Obstetrics &amp; 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