{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:00:17Z","timestamp":1783112417258,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>A surge in parvovirus B19 infections has been reported in 2023\u20132024 across Europe and the USA, raising concerns about the associated perinatal risks. The aim of this study was to compare perinatal outcomes following maternal parvovirus B19 infection during the 2023\u20132024 period with those from a pre\u20102023 cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter, retrospective cohort study compared perinatal outcomes in women with maternal parvovirus B19 infection according to whether infection occurred pre\u20102023 (2012\u20132022) or between 2023 and 2024. Pregnant women with confirmed parvovirus B19 infection were eligible for inclusion. Cases were excluded if they had incomplete records, an ongoing pregnancy, coinfection with cytomegalovirus or Epstein\u2013Barr virus, pre\u2010existing structural or genetic abnormality, immune fetal hydrops or a maternal serology result not indicative of parvovirus B19 infection. The primary outcome was perinatal mortality, which was defined as intrauterine fetal death \u2265\u200920\u2009weeks' gestation or neonatal death \u2264\u200928\u2009days after delivery. The secondary outcomes were persistent fetal anemia requiring more than one intrauterine transfusion (IUT) and a composite adverse perinatal outcome (CAPO), defined as the presence of one or more adverse outcomes, including perinatal mortality, pregnancy loss &lt;\u200920\u2009weeks, new\u2010onset structural anomaly and termination of pregnancy owing to parvovirus\u2010related morbidity. Differences between the two groups were assessed using standard statistical tests, and a generalized linear mixed model was used to identify predictors of perinatal mortality in the 2023\u20132024 cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following exclusions, 140 cases from pre\u20102023 and 175 cases from 2023\u20132024 were analyzed. The rate of fetal hydrops at presentation was similar across the two groups (22.9% in pre\u20102023\n                      <jats:italic>vs<\/jats:italic>\n                      23.4% in 2023\u20132024;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.905). The rates of perinatal mortality (6.4% in pre\u20102023\n                      <jats:italic>vs<\/jats:italic>\n                      8.0% in 2023\u20132024;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.294) and CAPO (17.9% in pre\u20102023\n                      <jats:italic>vs<\/jats:italic>\n                      21.7% in 2023\u20132024;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.395) were not significantly different between groups, but the proportion of fetuses with persistent fetal anemia requiring a second IUT was significantly higher in the 2023\u20132024 cohort (46.0%\n                      <jats:italic>vs<\/jats:italic>\n                      19.4%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.011). For the 2023\u20132024 cohort, fetal hydrops at presentation was an independent predictor of perinatal mortality (adjusted odds ratio, 10.91 (95%\u2009CI, 1.89\u201363.07);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In this multicenter collaboration, we report perinatal outcomes following maternal parvovirus B19 infection during the recent upsurge and compare them with those of a historical cohort. Although perinatal mortality and CAPO rates were similar between cohorts, cases in the recent surge (2023\u20132024) required more prenatal interventions, including the need for more than one IUT. Early identification and monitoring remain essential to mitigate adverse perinatal outcomes following maternal parvovirus B19 infection. \u00a9 2025 The Author(s).\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.29301","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T21:03:22Z","timestamp":1753909402000},"page":"307-313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Is parvovirus\n                    <scp>B19<\/scp>\n                    infection upsurge in 2023\u20132024 associated with adverse pregnancy outcome?"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2329-4470","authenticated-orcid":false,"given":"S.","family":"Prasad","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit St George's University Hospitals NHS Foundation Trust, University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2802-7670","authenticated-orcid":false,"given":"A.","family":"Khalil","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit St George's University Hospitals NHS Foundation Trust, University of London  London UK"},{"name":"Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute St George's University of London  London UK"},{"name":"Fetal Medicine Unit, Liverpool Women's Hospital  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0702-370X","authenticated-orcid":false,"given":"Y.","family":"Yinon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sheba Medical Center, Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Regev","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sheba Medical Center, Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5784-873X","authenticated-orcid":false,"given":"R.","family":"Brawura\u2010Biskupski\u2010Samaha","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Perinatology and Neonatology Centre of Postgraduate Medical Education  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Massoud","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University Hospitals Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Mazanowska","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Institute of Mother and Child  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7380-0576","authenticated-orcid":false,"given":"F. G.","family":"Sileo","sequence":"additional","affiliation":[{"name":"Prenatal Medicine Unit, Obstetrics and Gynaecology Unit, Department of Medical and Surgical Sciences for Mother, Child and Adult University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7793-714X","authenticated-orcid":false,"given":"F.","family":"Prefumo","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Unit IRCCS Istituto Giannina Gaslini  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3812-7560","authenticated-orcid":false,"given":"P.","family":"Kosinski","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Perinatology, Gynecology and Reproductive Medicine Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Morales Rosello","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology La Fe University and Polytechnic Hospital  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"D'Antonio","sequence":"additional","affiliation":[{"name":"Center for Fetal Care and High\u2010Risk Pregnancy, Department of Obstetrics and Gynecology University \u201cG. d'Annunzio\u201d of Chieti\u2010Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Collaborators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.3.485-505.2002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-59582-7"},{"key":"e_1_2_6_4_1","unstructured":"UK.HPR volume 18 issue 5: news (16 May 2024). 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