{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T20:15:28Z","timestamp":1784060128741,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["102431"],"award-info":[{"award-number":["102431"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/ICRF\/22\/26028"],"award-info":[{"award-number":["FS\/ICRF\/22\/26028"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the fetoplacental response to acute maternal hyperoxygenation (AMH) in fetuses with suspected coarctation of the aorta (CoA) using fetal cardiac magnetic resonance imaging (MRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pregnant women carrying a fetus with suspected CoA were recruited prospectively from a tertiary fetal cardiology center as part of the Fetal Imaging with Maternal Oxygen (FIMOx) study between February 2019 and April 2022. MRI included phase\u2010contrast flow measurements and oxygen\u2010sensitive T2* sequences to assess placental and fetal brain oxygenation. Results were analyzed on a groupwise basis, comparing true\u2010positive CoA cases (requiring surgical CoA repair \u2264\u200928\u2009days after birth) to false positives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fetal MRI with AMH was performed in 20 pregnancies (mean\u2009\u00b1\u2009SD gestational age, 33.0\u2009\u00b1\u20091.3\u2009weeks), of which five had CoA and 15 were false positives. In both groups, AMH significantly increased the placental T2* signal but had no effect on cerebral T2*. Increased pulmonary blood flow with AMH was associated with reduced right\u2013left shunting at the foramen ovale (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.74,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), but not with increased ascending aortic flow (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.36,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.177). Compared with baseline, AMH increased anterograde flow at the aortic isthmus from \u22122 (interquartile range (IQR), \u221257 to 10) mL\/kg\/min to 32 (IQR, \u221214 to 48) mL\/kg\/min (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001); however, this was associated with a reduction in superior vena cava flow (median, \u221229% (IQR,\u00a0\u221241% to 0%);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and not with changes in ascending aortic flow. No differences in baseline or AMH phase\u2010contrast or T2* values usefully distinguished true\u2010 and false\u2010positive cases in this pilot study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      AMH leads to a significant reduction in cerebral blood flow in fetuses with suspected CoA, which is the primary driver of changes in flow at the aortic isthmus. Future studies should consider the effects of maternal oxygen on the entirety of fetoplacental circulation, particularly for cases in which\u00a0chronic maternal hyperoxygenation administration is being considered. \u00a9 2025 The Author(s).\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.29303","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T07:23:22Z","timestamp":1752909802000},"page":"353-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Characterizing fetoplacental response to acute maternal hyperoxygenation in suspected coarctation of aorta using fetal cardiac\n                    <scp>MRI<\/scp>"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1739-4726","authenticated-orcid":false,"given":"M. P. M.","family":"van Poppel","sequence":"first","affiliation":[{"name":"Research Department of Early Life Imaging School of Biomedical Engineering and Imaging Sciences, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3366-0932","authenticated-orcid":false,"given":"J. K.","family":"Steinweg","sequence":"additional","affiliation":[{"name":"Research Department of Early Life Imaging School of Biomedical Engineering and Imaging Sciences, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Woodgate","sequence":"additional","affiliation":[{"name":"Research Department of Early Life Imaging School of Biomedical Engineering and Imaging Sciences, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Zidere","sequence":"additional","affiliation":[{"name":"Research Department of Early Life Imaging School of Biomedical Engineering and Imaging Sciences, King's College London  London UK"},{"name":"Department of Congenital Heart Disease Evelina London Children's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8391-7903","authenticated-orcid":false,"given":"T.","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease Evelina London Children's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3476-3500","authenticated-orcid":false,"given":"J.","family":"Hutter","sequence":"additional","affiliation":[{"name":"Research Department of Early Life Imaging School of Biomedical Engineering and Imaging Sciences, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Razavi","sequence":"additional","affiliation":[{"name":"Research Department of Early Life Imaging School of Biomedical Engineering and Imaging Sciences, King's College London  London UK"},{"name":"Department of Congenital Heart Disease Evelina London Children's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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