{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:02:19Z","timestamp":1782946939270,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Offline fusion imaging refers to\n                      <jats:italic>a posteriori<\/jats:italic>\n                      merging of two datasets, from the same or from different imaging modalities. The objectives were to assess the feasibility of a standardized manual method for the offline fusion of three\u2010dimensional (3D) ultrasound (US) and magnetic resonance imaging (MRI) data in demonstrating normal fetal brain development and to evaluate its potential clinical use throughout pregnancy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective study conducted at the Necker\u2010Enfants Malades Hospital, Paris, France, from January to September 2021. We included normal singleton pregnancies between 16\u2009+\u20090 and 36\u2009+\u20090\u2009weeks' gestation. Each patient underwent a 3D\u2010US scan, with and without Micro\u2010Vascularization Imaging Doppler, immediately followed by a T2\u2010weighted MRI examination (1.5\u2009Tesla) of the fetal brain. 3D\u2010US and MRI images were merged using at least three registration landmarks, using modified 4D View Fusion software. The primary outcome was the success of US\u2013MRI fusion imaging in obtaining three usable orthogonal planes. Secondary outcomes were the rate of entire neurosonogram visualization (on 3D\u2010US acquisitions, MRI stacks and US\u2013MRI fusion imaging) and the rate of visualization of each International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) neurosonogram anatomical landmark.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 113 pregnant women were included in the analysis. We obtained usable datasets in the three orthogonal planes for 3D\u2010US and MRI in 87.6%\u00a0(99\/113) and 97.3% (110\/113) of cases respectively. Usable US\u2013MRI fusion imaging in the three planes was achieved in 85.8% (85\/99) of cases. The entire neurosonogram was obtained in 9.4% (8\/85), 74.1% (63\/85) and 87.1% (74\/85) respectively of 3D\u2010US acquisitions, MRI stacks and US\u2013MRI fusion imaging volumes (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      We present a promising offline 3D\u2010US\u2013MRI fusion imaging tool that permits navigation within two merged volumes acquired on the same day. This technique seems easily achievable and may be of value for educational purposes and longitudinal follow up of fetal brain development in cases with increased risk of brain abnormalities. \u00a9 2025 The Author(s).\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.29312","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T08:21:02Z","timestamp":1755591662000},"page":"509-517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Offline ultrasound\u2013\n                    <scp>MRI<\/scp>\n                    fusion imaging for assessment of normal fetal brain development"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7484-2495","authenticated-orcid":false,"given":"C.","family":"Codaccioni","sequence":"first","affiliation":[{"name":"EA fetus 7328 and LUMIERE platform, Universit\u00e9 de Paris  Paris France"},{"name":"H\u00f4pital Necker Enfants Malades, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7937-3648","authenticated-orcid":false,"given":"C.","family":"Arthuis","sequence":"additional","affiliation":[{"name":"EA fetus 7328 and LUMIERE platform, Universit\u00e9 de Paris  Paris France"},{"name":"H\u00f4pital Necker Enfants Malades, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"},{"name":"Service de Gyn\u00e9cologie\u2010Obst\u00e9trique, Sant\u00e9 Atlantique Elsan  Saint Herblain France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Deloison","sequence":"additional","affiliation":[{"name":"EA fetus 7328 and LUMIERE platform, Universit\u00e9 de Paris  Paris France"},{"name":"H\u00f4pital Necker Enfants Malades, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010P.","family":"Bault","sequence":"additional","affiliation":[{"name":"EA fetus 7328 and LUMIERE platform, Universit\u00e9 de Paris  Paris France"},{"name":"H\u00f4pital Necker Enfants Malades, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Henry","sequence":"additional","affiliation":[{"name":"EA fetus 7328 and LUMIERE platform, Universit\u00e9 de Paris  Paris France"},{"name":"H\u00f4pital Necker Enfants Malades, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP)  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de Paris (AP\u2010HP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5675-267X","authenticated-orcid":false,"given":"Y.","family":"Ville","sequence":"additional","affiliation":[{"name":"EA fetus 7328 and LUMIERE platform, Universit\u00e9 de Paris  Paris France"},{"name":"H\u00f4pital Necker Enfants Malades, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"},{"name":"Service de Gyn\u00e9cologie\u2010Obst\u00e9trique, H\u00f4pital Necker\u2010Enfants Malades, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Grevent","sequence":"additional","affiliation":[{"name":"EA fetus 7328 and LUMIERE platform, Universit\u00e9 de Paris  Paris France"},{"name":"H\u00f4pital Necker Enfants Malades, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"},{"name":"Service de Radiologie, 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