{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:28:45Z","timestamp":1783031325159,"version":"3.54.6"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate longitudinal changes in fetal growth parameters, umbilical artery (UA) Doppler measurements and amniotic fluid index (AFI) in East Asian pregnant women who underwent screening for preterm pre\u2010eclampsia (PE) in the first trimester, and to evaluate correlations of these variables with first\u2010trimester biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective, longitudinal, nested case\u2013control study of women with a singleton pregnancy who participated in the first\u2010trimester screen\u2010and\u2010prevent program for preterm PE at the Prince of Wales Hospital, Hong Kong SAR, China, between January 2020 and December 2023. The risk of developing preterm PE was determined using the Fetal Medicine Foundation first\u2010trimester triple test. High\u2010risk women (adjusted risk \u2265\u20091:100) were administered a daily dose of aspirin at either 100\u2009mg or 160\u2009mg according to maternal weight, starting before 16\u2009weeks and continuing until 36\u2009weeks' gestation, or earlier than 36\u2009weeks in the case of delivery or development of PE. Low\u2010risk women were matched based on maternal age, weight and the calendar date of enrolment. Biomarkers including mean arterial pressure, uterine artery (UtA) pulsatility index (PI) and placental growth factor (PlGF) were measured at the recruitment visit. Participants were followed up at 20\u2009+\u20090 to 24\u2009+\u20096\u2009weeks and 30\u2009+\u20090 to 37\u2009+\u20096\u2009weeks to measure fetal biparietal diameter, head circumference, abdominal circumference, femur length, estimated fetal weight, UA\u2010PI and AFI. Multilevel linear mixed\u2010effects modeling was used to assess longitudinal changes in fetal growth parameters, UA\u2010PI and AFI. Pearson's coefficient was used to assess the correlation of first\u2010trimester biomarkers with fetal growth parameters, UA\u2010PI and AFI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our cohort comprised 509 low\u2010risk women who did not develop PE, 1879 high\u2010risk women who did not develop PE and 184 high\u2010risk women who developed PE. At midgestation, mean\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores of most fetal growth parameters were significantly lower in the high\u2010risk women who developed PE compared with those of the other groups. This pattern persisted into late gestation. AFI was consistently lower in high\u2010risk pregnancies, with the greatest decrease between visits observed in those who developed PE. High\u2010risk women who developed PE had the highest mean UA\u2010PI\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010score at mid\u2010gestation, which decreased by late gestation but remained elevated compared with the other two groups. UtA\u2010PI was correlated negatively with fetal growth parameters, while PlGF showed a positive correlation with fetal growth parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Differences in fetal growth, UA\u2010PI and AFI exist between women identified as low\n                      <jats:italic>vs<\/jats:italic>\n                      high risk for preterm PE based on first\u2010trimester screening, especially in high\u2010risk women who develop PE. These findings are evident as early as the second trimester and persist into the third trimester. This highlights the need for a structured antenatal management plan with fetal monitoring in high\u2010risk cases, irrespective of aspirin prophylaxis. \u00a9 2025 The Author(s).\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.29313","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T07:39:54Z","timestamp":1754638794000},"page":"314-323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal fetal growth parameters in women at high risk for pre\u2010eclampsia"],"prefix":"10.1002","volume":"66","author":[{"given":"Y. K.","family":"Yeung","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Nguyen\u2010Hoang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR China"},{"name":"Fetal Medicine Centre, Tam Anh HCMC General Hospital  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. W.","family":"Tse","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2082-8476","authenticated-orcid":false,"given":"N. K. L","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4140-6651","authenticated-orcid":false,"given":"A. H.","family":"Kwan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. L.","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4565-1280","authenticated-orcid":false,"given":"N. M. W.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. S.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3944-4130","authenticated-orcid":false,"given":"L. C.","family":"Poon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR China"},{"name":"Shenzhen Research Institute The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60279-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2021.09.008"},{"issue":"1","key":"e_1_2_7_4_1","first-page":"80","article-title":"World Health Organization International Collaborative Study of Hypertensive Disorders of Pregnancy","volume":"158","author":"Geographic variation in the incidence of hypertension in pregnancy","year":"1988","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1081\/PRG-120021060"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.14580"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.14781"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2014.103"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61351-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.976198"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm.2011.098"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(14)70227-X"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12802"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6268276"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006815"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5320"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22134"},{"issue":"2","key":"e_1_2_7_18_1","article-title":"ACOG Practice Bulletin, Number 227","volume":"137","author":"Fetal Growth Restriction","year":"2021","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19112"},{"issue":"2","key":"e_1_2_7_20_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2020.07.020","article-title":"First trimester preeclampsia screening and prediction","volume":"226","author":"Chaemsaithong P","year":"2022","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"e_1_2_7_21_1","first-page":"45","article-title":"Soluble fms\u2010like tyrosine kinase\u20101 and placental growth factor in Chinese pregnant women during second and third trimesters","volume":"24","author":"Cheng YK","year":"2018","journal-title":"Hong Kong Med J"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.06.028"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.069907"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.11.561"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6252"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1975.tb00708.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1994.tb13078.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90298-4"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002284"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.107325"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.09.019"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4088"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20272"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2017.08.002"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5157"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13257"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22175"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17514"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.09.041"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5372"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5192"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.01.012"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2008.04.007"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.10.813"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)01040-1"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm.2010.041"},{"issue":"6","key":"e_1_2_7_47_1","article-title":"Fetal and umbilical Doppler ultrasound in high\u2010risk pregnancies","volume":"6","author":"Alfirevic Z","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-972926"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704559"},{"issue":"7","key":"e_1_2_7_50_1","first-page":"551","article-title":"Early administration of low\u2010dose aspirin for the prevention of severe and mild preeclampsia: a systematic review and meta\u2010analysis","volume":"29","author":"Roberge S","year":"2012","journal-title":"Am J Perinatol"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.09.076"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.29313","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.29313","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.29313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:01:54Z","timestamp":1770836514000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.29313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,8]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/uog.29313"],"URL":"https:\/\/doi.org\/10.1002\/uog.29313","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,8]]},"assertion":[{"value":"2025-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}