{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T20:13:53Z","timestamp":1776024833770,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,15]],"date-time":"2007-01-15T00:00:00Z","timestamp":1168819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the role of maternal demographic characteristics, uterine artery Doppler velocimetry, maternal serum pregnancy\u2010associated plasma protein\u2010A (PAPP\u2010A) and their combination in screening for pre\u2010eclampsia and small\u2010for\u2010gestational age (SGA) fetuses at 11\u201314 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective study of 878 consecutive women presenting for a routine prenatal ultrasound examination at 11\u201314 weeks. Pulsed wave Doppler was then used to obtain uterine artery flow velocity waveforms and the mean pulsatility index (PI) of the uterine arteries was calculated. Maternal serum samples for PAPP\u2010A were assayed. Along with maternal history, these measurements were compared in their ability to predict adverse outcome, defined as pre\u2010eclampsia and\/or SGA and\/or placental abruption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean uterine artery PI \u2265 95<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup> centile and PAPP\u2010A \u2264 10<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup> centile each predicted 23% of the women that developed pre\u2010eclampsia and 43% of cases of placental abruption. For SGA \u2264 5<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup> centile, mean uterine artery PI \u2265 95<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup> centile predicted 23% of cases and PAPP\u2010A \u2264 10<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup> centile predicted 34%. Independent predictors for subsequent development of pre\u2010eclampsia were increased mean uterine artery PI \u2265 95<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup> centile (OR, 2.76; 95% CI, 1.11\u20136.81) and maternal history of pre\u2010eclampsia\/hypertension (OR, 50.54; 95% CI, 10.52\u2013242.73). The predicting factors for SGA \u2264 5<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup> centile were increased mean uterine artery PI \u2265 95<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup> centile (OR, 2.0; 95% CI, 1.07\u20133.74) and low PAPP\u2010A (OR, 0.43; 95% CI, 0.20\u20130.93). Increased uterine artery PI was the only independent factor in the prediction of placental abruption (OR, 8.49; 95% CI, 2.78\u201325.94). The combination of uterine artery PI and maternal history of pre\u2010eclampsia\/hypertension was better than was using uterine artery Doppler alone in predicting pre\u2010eclampsia. Similarly, for the prediction of SGA \u2264 5<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup> centile, combining uterine artery Doppler and maternal serum PAPP\u2010A was better than was uterine artery Doppler alone. In both cases, the difference approached statistical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of maternal history with abnormal uterine artery Doppler and low PAPP\u2010A level at 11\u201314 weeks achieves better results than does either test alone in the prediction of pre\u2010eclampsia and SGA. Copyright \u00a9 2007 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.3881","type":"journal-article","created":{"date-parts":[[2007,1,15]],"date-time":"2007-01-15T10:52:48Z","timestamp":1168858368000},"page":"135-140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":148,"title":["Screening for pre\u2010eclampsia and fetal growth restriction by uterine artery Doppler and PAPP\u2010A at 11\u201314 weeks' gestation"],"prefix":"10.1002","volume":"29","author":[{"given":"A.","family":"Pilalis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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