{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:32:36Z","timestamp":1791045156077,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,1,3]],"date-time":"2007-01-03T00:00:00Z","timestamp":1167782400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the immediate postinterventional and long\u2010term outcomes of children with a prenatal and those with a postnatal diagnosis of isolated congenital heart defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of 257 children admitted over a 10\u2010year period to our pediatric cardiology unit with one of four different cardiac lesions: transposition of the great arteries, atrioventricular canal defect, tetralogy of Fallot and pulmonary atresia; 208 were diagnosed postnatally and 49 prenatally. Management was identical in the two patient groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age at admission was 22 days in the postnatal group and 10 days in the prenatal group. In the prenatal group there was a higher median preoperative O<jats:sub>2<\/jats:sub> saturation level (<jats:italic>P<\/jats:italic> = 0.07), fewer cases of preoperative cardiac failure (<jats:italic>P<\/jats:italic> = 0.03), fewer cases of preoperative closure of the duct (<jats:italic>P<\/jats:italic> = 0.04), a shorter median duration of postoperative mechanical ventilation (<jats:italic>P<\/jats:italic> = 0.03), less need for resurgery (<jats:italic>P<\/jats:italic> = 0.02) and a shorter median duration of stay in the intensive care unit (<jats:italic>P<\/jats:italic> = 0.05). Postoperative survival was 96% in the prenatal group and 90% in the postnatal group. Assessment of long\u2010term survival revealed a longer catheter intervention\u2010free interval in the prenatal group (<jats:italic>P<\/jats:italic> = 0.03). At the 1\u2010year follow\u2010up, residual impaired cardiac function was less frequent in the prenatal than in the postnatal group (<jats:italic>P<\/jats:italic> = 0.04). Overall survival at maximum follow\u2010up was 92% in the prenatal and 84% in the postnatal group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prenatal diagnosis of isolated congenital heart defects allows admission for surgery in a more stable condition and is associated with lower short\u2010term and long\u2010term morbidity and mortality. Copyright \u00a9 2007 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.3900","type":"journal-article","created":{"date-parts":[[2007,1,3]],"date-time":"2007-01-03T18:22:31Z","timestamp":1167848551000},"page":"38-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Immediate and long\u2010term outcomes in children with prenatal diagnosis of selected isolated congenital heart defects"],"prefix":"10.1002","volume":"29","author":[{"given":"I. 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W.","family":"Dudenhausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Henrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,3]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00398.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0516"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)04069-X"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00586.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.7.916"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.9.1269"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)34676-8"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2004.11.027"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00259-9"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)33933-9"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpme.1983.11.4.200"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-993934"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200301000-00004"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.6.1325"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.6.562"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00172-1"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00788220"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.82.5.594"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1053\/sper.2000.16550"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.146"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.10040237.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.87.1.67"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.125227"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(03)00183-5"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2005.tb02046.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.4.743"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.3900","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.3900","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.3900","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.3900","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T17:08:15Z","timestamp":1692551295000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.3900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1002\/uog.3900"],"URL":"https:\/\/doi.org\/10.1002\/uog.3900","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"2006-11-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-01-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}