{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:35:09Z","timestamp":1789587309906,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,3,27]],"date-time":"2007-03-27T00:00:00Z","timestamp":1174953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the quantity and quality of endometrial tissue sampled at saline contrast sonohysterography (SCSH) with that obtained by directed endometrial biopsy by operative hysteroscopy in patients with diffusely thickened and\/or inhomogeneous endometrium at SCSH. A secondary aim was a comparison of the extent of procedure\u2010related pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and twenty\u2010eight patients with diffusely thickened (&gt; 4 mm) and\/or inhomogeneous endometrium at SCSH were prospectively recruited. Endometrial sampling was performed at the end of SCSH using the same 4.7\u2010mm intrauterine catheter that had been used for saline instillation. These samples were compared to directed endometrial biopsies obtained with the guidance of an office 5\u2010mm hysteroscope. After hysteroscopy, an extended guided curettage was performed under general anesthesia, providing specimens that were considered the gold standard for histological diagnosis. Endometrial specimen area (mm<jats:sup>2<\/jats:sup>), histologic concordance and procedure related pain (10\u2010cm VAS) were compared for the two techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age of 88 pre\u2010 and of 40 post\u2010menopausal patients was 41 (interquartile range, 34\u201348) years and 57 (interquartile range, 52\u201367) years, respectively. The median area of endometrial specimen obtained by SCSH was 25.1 (interquartile range, 12.4\u201352.3) mm<jats:sup>2<\/jats:sup> and was not significantly different from that obtained by hysteroscopy (16.9 (interquartile range, 10.0\u201352.7) mm<jats:sup>2<\/jats:sup>). The K values of the two different techniques for typical hyperplasia (<jats:italic>n<\/jats:italic> = 61) and for premalignant and malignant lesions (<jats:italic>n<\/jats:italic> = 26) were 0.91 and 0.94, respectively. Procedure\u2010related pain was not significantly different between pre\u2010 and postmenopausal patients for both sampling techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SCSH with sampling proved to be as good as and as tolerable as hysteroscopic biopsy in cases with diffusely thickened and\/or inhomogeneous endometrium. Both these imaging and biopsy techniques should be considered a reliable outpatient procedure in the management of patients with abnormal uterine bleeding. Copyright \u00a9 2007 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.3981","type":"journal-article","created":{"date-parts":[[2007,3,27]],"date-time":"2007-03-27T17:20:35Z","timestamp":1175016035000},"page":"443-448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Sonohysterographic endometrial sampling and hysteroscopic endometrial biopsy: a comparative study"],"prefix":"10.1002","volume":"29","author":[{"given":"F. P. G.","family":"Leone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Carsana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lanzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Vago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ferrazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90483-2"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1996.07050315.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.17.1510"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/00006250-200309000-00058","article-title":"ACOG technology assessment in obstetrics and gynecology. Number 3, September 2003. Saline infusion sonohysterography","volume":"102","author":"Breitkopf D","year":"2003","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2003.02472.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70446-0"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00472.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2003.00191.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)04916-6"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870210203"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2003.09.008"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.14010058.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(03)00080-8"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5122(03)00152-X"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.13.1610"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)00546-6"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)00643-8"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00015.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)01941-0"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/01443610120101817"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)02559-6"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-3804(05)60406-9"},{"key":"e_1_2_6_24_2","volume-title":"Pathology of the Female Reproductive Tract","author":"Robboy SJ","year":"2002"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199910000-00012"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)01792-1"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2001.801210.x"},{"key":"e_1_2_6_28_2","first-page":"553","article-title":"Pipelle endometrial sampling. Sensitivity in the detection of endometrial cancer","volume":"40","author":"Guido RS","year":"1995","journal-title":"J Reprod Med"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1159\/000077393"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2599"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.123056"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00445.x"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70294-7"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.3981","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.3981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T12:06:39Z","timestamp":1696680399000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.3981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,27]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1002\/uog.3981"],"URL":"https:\/\/doi.org\/10.1002\/uog.3981","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,27]]},"assertion":[{"value":"2006-10-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}