{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:33:19Z","timestamp":1789410799617,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,7,30]],"date-time":"2007-07-30T00:00:00Z","timestamp":1185753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate changes in the temporal evolution and regional distribution of arterial brain Doppler parameters in relation to different stages of hemodynamic adaptation in fetuses with severe intrauterine growth restriction (IUGR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010six fetuses with severe IUGR (\u2264 32 weeks of gestation) and abnormal umbilical artery (UA) pulsatility index (PI) (mean &gt; 2 SD) were evaluated longitudinally with pulsed Doppler ultrasound at four different hemodynamic stages: Stage 1 (<jats:italic>n<\/jats:italic> = 36), mean UA\u2010PI &gt; 2 SD or absent UA end\u2010diastolic flow; Stage 2 (<jats:italic>n<\/jats:italic> = 34), abnormal middle cerebral artery (MCA) PI (mean &lt; 2 SD); Stage 3 (<jats:italic>n<\/jats:italic> = 30), reversed UA end\u2010diastolic flow; Stage 4 (<jats:italic>n<\/jats:italic> = 12), absent or reversed atrial flow in the ductus venosus. In addition, 36 normally grown fetuses were studied for comparison. PI and time\u2010averaged maximum velocity (TAMXV) in the MCA and the anterior cerebral (ACA), pericallosal (PER) and posterior cerebral (PCA) arteries were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In IUGR fetuses, PI values from all arteries were significantly reduced at Stage 2. At Stages 3 and 4, ACA\u2010PI and PCA\u2010PI did not change further, whereas MCA\u2010PI and PER\u2010PI showed a slight increase. In the ACA, MCA and PER, TAMXV in Stage 2 increased significantly. In Stages 3 and 4, ACA and PER\u2010TAMXV remained unchanged, whereas MCA\u2010TAMXV showed a slight decrease, mirroring the PI values. PCA\u2010TAMXV values were similar to controls at all stages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In IUGR fetuses, the brain arteries differ in the magnitude and time sequence of Doppler parameters in relation to systemic hemodynamic adaptation, suggesting the existence of regional brain redistribution processes. Copyright \u00a9 2007 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.4084","type":"journal-article","created":{"date-parts":[[2007,7,30]],"date-time":"2007-07-30T10:19:39Z","timestamp":1185790779000},"page":"297-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Doppler changes in the main fetal brain arteries at different stages of hemodynamic adaptation in severe intrauterine growth restriction"],"prefix":"10.1002","volume":"30","author":[{"given":"H.","family":"Figueroa\u2010Diesel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Hernandez\u2010Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Acosta\u2010Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Cabero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Gratacos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,7,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(03)00179-9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2005.07.004"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000243880"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1996.08030152.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.2.e77"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.08.026"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00501.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199707000-00010"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2005.tb02009.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-199504000-00003"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1990.258.4.H1064"},{"key":"e_1_2_6_13_2","first-page":"H613","article-title":"Responses to acute hypoxemia in fetal sheep at 0.6\u20130.7 gestation","volume":"256","author":"Iwamoto HS","year":"1989","journal-title":"Am J Physiol"},{"key":"e_1_2_6_14_2","first-page":"309","article-title":"Effects of reducing uterine blood flow on fetal blood flow distribution and oxygen delivery","volume":"15","author":"Jensen A","year":"1991","journal-title":"J Dev Physiol"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.181.1.1887021"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00591.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(91)90817-O"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1989.tb03326.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1994.tb13151.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00758.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2001.00222.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.117356"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.17.2.101.109"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1003"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.1.129"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90161-2"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2000.034"}],"container-title":["Ultrasound in Obstetrics &amp; 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