{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:06:24Z","timestamp":1792479984255,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,11,9]],"date-time":"2007-11-09T00:00:00Z","timestamp":1194566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the clinical utility of the first\u2010trimester markers of aneuploidy in their ability to predict preterm delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined 54 722 singleton pregnancies with no chromosomal abnormality and with complete outcome data that had undergone screening for trisomy 21 by a combination of fetal nuchal translucency (NT) thickness and maternal serum free \u03b2\u2010human chorionic gonadotropin (\u03b2\u2010hCG) and pregnancy\u2010associated plasma protein\u2010A (PAPP\u2010A) at 11 + 0 and 13 + 6 weeks' gestation. The biochemical markers were converted to multiples of the median (MoM) of the expected normal median for a pregnancy of the same gestation and the measurements of fetal NT were expressed as the difference (delta) from the normal median NT for crown\u2013rump length. The association between free \u03b2\u2010hCG, PAPP\u2010A and delta NT and the incidence of preterm delivery before 37 weeks or early preterm delivery before 34 weeks was assessed by comparing the relative incidence at a number of MoM or delta NT cut\u2010offs and at various centile cut\u2010offs. At various marker levels the likelihood ratios (LR) for preterm delivery and early preterm delivery were also calculated after excluding other adverse pregnancy complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The risk of preterm delivery increased with decreasing maternal serum PAPP\u2010A. In the 3132 cases delivering before 37 weeks the PAPP\u2010A MoM was 0.91 and in the 1060 cases delivering before 34 weeks the PAPP\u2010A MoM was 0.90. At the 5<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup> centile of the normal outcome group for PAPP\u2010A (0.415 MoM) the odds ratios for delivery before 37 weeks and before 34 weeks were 1.92 and 2.35, respectively. The respective values for the 5<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup> centile of free \u03b2\u2010hCG (0.41 MoM) were 1.18 and 1.08 and for the 95<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup> centile of delta NT they were 0.91 and 0.77, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low levels of maternal serum PAPP\u2010A are associated, in the absence of an abnormal karyotype, with an increased risk of preterm or early preterm delivery. The LR profiles provided at various levels of PAPP\u2010A may be of some help in counseling women with such results and may raise awareness among healthcare professionals for increased surveillance in such cases. Copyright \u00a9 2007 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.5163","type":"journal-article","created":{"date-parts":[[2007,11,9]],"date-time":"2007-11-09T12:16:31Z","timestamp":1194610591000},"page":"147-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["First\u2010trimester ultrasound and biochemical markers of aneuploidy and the prediction of preterm or early preterm delivery"],"prefix":"10.1002","volume":"31","author":[{"given":"K.","family":"Spencer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. J.","family":"Cowans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. O.","family":"Kagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. H.","family":"Nicolaides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,2,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.13040231.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199911)19:11<1035::AID-PD694>3.0.CO;2-2"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(200005)20:5<411::AID-PD822>3.0.CO;2-2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0223(200006)20:6<495::AID-PD846>3.0.CO;2-U"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.02246.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.03.021"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1860"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb11618.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00575.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041367"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90015-H"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00577.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.186"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.13030167.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0223(200006)20:6<491::AID-PD844>3.0.CO;2-3"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.708"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.819"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1153"},{"key":"e_1_2_6_20_2","first-page":"519","article-title":"UK multicentre project on assessment of risk for trisomy 21 by maternal age and fetal nuchal translucency thickness at 10\u201314 weeks of gestation","volume":"18","author":"Snijders RJM","year":"1998","journal-title":"Lancet"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(87)90099-5"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1665"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3809"},{"key":"e_1_2_6_24_2","article-title":"First\u2010trimester biochemical markers of aneuploidy and the prediction of small\u2010for\u2010gestational age fetuses","author":"Spencer K","year":"2007","journal-title":"Ultrasound Obstet Gynecol"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1251"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.4.8430"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.052"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.05.068"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-199911001-00043"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000150559.59531.b2"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2773"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.407"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1159\/000079000"},{"key":"e_1_2_6_34_2","first-page":"89","article-title":"Maternal serum free \u03b2\u2010hCG levels in uncomplicated pregnancies at the 10th\u201315th week of gestation and the development of obstetric complications","volume":"49","author":"De Leon J","year":"2004","journal-title":"J Reprod Med"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199802)18:2<147::AID-PD231>3.0.CO;2-W"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.735"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.5163","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.5163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T07:42:42Z","timestamp":1696750962000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.5163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1002\/uog.5163"],"URL":"https:\/\/doi.org\/10.1002\/uog.5163","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2]]},"assertion":[{"value":"2007-08-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-02-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}